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DC Field | Value | Language |
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dc.contributor.author | Rafacho, A. | - |
dc.contributor.author | Abrantes, J. L. F. | - |
dc.contributor.author | Ribeiro, D. L. | - |
dc.contributor.author | Paula, F. M. | - |
dc.contributor.author | Pinto, M. E. | - |
dc.contributor.author | Boschero, A. C. | - |
dc.contributor.author | Bosqueiro, José Roberto | - |
dc.date.accessioned | 2014-05-20T14:00:48Z | - |
dc.date.accessioned | 2016-10-25T17:08:11Z | - |
dc.date.available | 2014-05-20T14:00:48Z | - |
dc.date.available | 2016-10-25T17:08:11Z | - |
dc.date.issued | 2011-04-01 | - |
dc.identifier | http://dx.doi.org/10.1055/s-0030-1269896 | - |
dc.identifier.citation | Hormone and Metabolic Research. Stuttgart: Georg Thieme Verlag Kg, v. 43, n. 4, p. 275-281, 2011. | - |
dc.identifier.issn | 0018-5043 | - |
dc.identifier.uri | http://hdl.handle.net/11449/21474 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/21474 | - |
dc.description.abstract | Long-term dexamethasone therapy may induce peripheral insulin resistance (IR), which in turn elicits increased beta-cell function and proliferation. However, whether such adaptive compensations occur during short-term treatment with dexamethasone is unclear. Here, we compared morphofunctional parameters in endocrine pancreas after short- and long-term dexamethasone administration. Groups of rats received daily i.p. injection of 1 mg/kg b.w. dexamethasone for 1 (DEX-1), 3 (DEX-3), or 5 consecutive days (DEX-5), whilst control rats were saline-treated (CTL). Despite the absence of apparent IR in DEX-1 rats, this group exhibited increased circulating insulin levels and glucose-stimulated insulin secretion (GSIS), compared to the CTL group (p < 0.05). Evident IR as well as marked hyperinsulinemia and GSIS, as judged by the static and dynamic insulin secretion values, were observed in DEX-3 and DEX-5 rats (p < 0.05). GSIS in islets cultured with 1 mu M dexamethasone was lower compared to the control (p < 0.05). Marked increases in beta-cell proliferation were observed in DEX-3 and DEX-5 rats, compared to CTL and DEX-1 rats (p < 0.05). The alterations observed in DEX-3 rats were more pronounced in DEX-5 rats, which also exhibited a higher content of islet Cdk4 and Cd2 proteins, compared to the CTL group (p < 0.05). We conclude that short-term dexamethasone treatment (DEX-1) induces an increase in beta-cell function that does not require the presence of discernible IR. As the treatment continues, the IR develops rapidly, and increased insulin secretion as well as beta-cell hyperplasia is demanded for the appropriate maintenance of glucose homeostasis. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.description.sponsorship | INOD (Instituto Nacional de Obesidade e Diabetes) | - |
dc.format.extent | 275-281 | - |
dc.language.iso | eng | - |
dc.publisher | Georg Thieme Verlag Kg | - |
dc.source | Web of Science | - |
dc.subject | beta-cell proliferation | en |
dc.subject | dexamethasone | en |
dc.subject | Glucocorticoid | en |
dc.subject | insulin secretion | en |
dc.subject | insulin resistance | en |
dc.subject | short- and long-term treatment | en |
dc.title | Morphofunctional Alterations in Endocrine Pancreas of Short- and Long-term Dexamethasone-treated Rats | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Universidade Estadual de Campinas (UNICAMP) | - |
dc.description.affiliation | UNESP Univ Estadual Paulista, Dept Phys Educ, Sch Sci, Bauru, SP, Brazil | - |
dc.description.affiliation | Univ Estadual Campinas, UNICAMP, Dept Anat Cellular Biol & Physiol & Biophys, Inst Biol, Campinas, SP, Brazil | - |
dc.description.affiliation | UNESP, Dept Biol, Inst Biosci Letters & Exact Sci, Sao Jose do Rio Preto, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP Univ Estadual Paulista, Dept Phys Educ, Sch Sci, Bauru, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP, Dept Biol, Inst Biosci Letters & Exact Sci, Sao Jose do Rio Preto, SP, Brazil | - |
dc.identifier.doi | 10.1055/s-0030-1269896 | - |
dc.identifier.wos | WOS:000288984100009 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Hormone and Metabolic Research | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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