Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/21562
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Molina, Fernando D. | - |
dc.contributor.author | Santos, Fernanda C. A. | - |
dc.contributor.author | Falleiros, Luis R. | - |
dc.contributor.author | Goloni-Bertollo, Eny M. | - |
dc.contributor.author | Felisbino, Sergio L. | - |
dc.contributor.author | Justulin, Luis A. | - |
dc.contributor.author | Maniglia, Jose V. | - |
dc.contributor.author | Taboga, Sebastiao R. | - |
dc.date.accessioned | 2014-05-20T14:01:01Z | - |
dc.date.accessioned | 2016-10-25T17:08:21Z | - |
dc.date.available | 2014-05-20T14:01:01Z | - |
dc.date.available | 2016-10-25T17:08:21Z | - |
dc.date.issued | 2011-05-01 | - |
dc.identifier | http://dx.doi.org/10.1002/jemt.20927 | - |
dc.identifier.citation | Microscopy Research and Technique. Malden: Wiley-blackwell, v. 74, n. 5, p. 430-439, 2011. | - |
dc.identifier.issn | 1059-910X | - |
dc.identifier.uri | http://hdl.handle.net/11449/21562 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/21562 | - |
dc.description.abstract | Obstructive sleep apnea hypopnea syndrome (SAHS) is a complex disease of the upper respiratory airways. SAHS physiopathology is multifactorial in which airway compliance is a very important component. To evaluate the tissue changes in the palatopharyngeal muscle by morphometric, histochemical, immunohistochemical, and stereological quantification, with special attention to extracellular matrix associated with this muscle at the structural and ultrastructural levels. Thirty patients with SAHS were divided into groups of 10 according to disease severity: mild, moderate, and severe SAHS. In addition, the control group consisted of 10 patients. Fragments of palatopharyngeal muscle removed from patients with SAHS and tonsillectomies from patients in the control group were histopathologically submitted to light microscopy and transmission electron microscopy. Histopathological evaluations by light and transmission electron microscopes showed differences in analyzed groups, such as reduction of the muscle fiber diameter in patients with SAHS, taking disease severity into consideration. In contrast, stereological analysis showed a gradual increase of the collagen and elastic system fibers relative frequencies, proportionally to SAHS seriousness. MMP-2 and MMP-9 immunostaining also showed an increased reaction in the muscle fiber cytoplasm and endomisium during SAHS progression. The ultrastructural analysis showed that palatopharyngeal muscle fibers presented cytoplasmic residual corpuscles, a sign of early cell aging. In conclusion, the increase of tissue compliance in individuals with SAHS can be, in addition to other factors, consequence of diminished contractile activity of the muscle fibers, which exhibited clear signs of early senescence. Moreover, extracellular matrix components changes may contribute to muscle myopathy during SAHS progression. Microsc. Res. Tech. 74:430-439, 2011. (C) 2010Wiley-Liss, Inc. | en |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.format.extent | 430-439 | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-Blackwell | - |
dc.source | Web of Science | - |
dc.subject | apnea | en |
dc.subject | muscle | en |
dc.subject | pharynx | en |
dc.subject | extracellular matrix | en |
dc.title | Microscopical Evaluation of Extracellular Matrix and Its Relation to the Palatopharyngeal Muscle in Obstructive Sleep Apnea | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Faculdade de Medicina de São José do Rio Preto (FAMERP) | - |
dc.contributor.institution | Universidade Federal de Goiás (UFG) | - |
dc.contributor.institution | Universidade Federal do Triângulo Mineiro (UFTM) | - |
dc.description.affiliation | IBILCE UNESP, Inst Biosci Hummanities & Exact Sci, Dept Biol, BR-15054000 Sao Jose do Rio Preto, SP, Brazil | - |
dc.description.affiliation | Sao Jose do Rio Preto FAMERP, Sch Med, Dept Otorhinolaryngol, São Paulo, Brazil | - |
dc.description.affiliation | Sao Jose do Rio Preto FAMERP, Sch Med, Serv Head & Neck Surg, São Paulo, Brazil | - |
dc.description.affiliation | Universidade Federal de Goiás (UFG), Dept Morfol, Goiania, Go, Brazil | - |
dc.description.affiliation | Univ Estadual Paulista, Dept Morphol, Inst Biosci, São Paulo, Brazil | - |
dc.description.affiliation | Univ Fed Triangulo Mineiro, Dept Morfol, Uberaba, MG, Brazil | - |
dc.description.affiliationUnesp | IBILCE UNESP, Inst Biosci Hummanities & Exact Sci, Dept Biol, BR-15054000 Sao Jose do Rio Preto, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Dept Morphol, Inst Biosci, São Paulo, Brazil | - |
dc.description.sponsorshipId | CNPq: 300163/2008-8 | - |
dc.identifier.doi | 10.1002/jemt.20927 | - |
dc.identifier.wos | WOS:000289636200006 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Microscopy Research and Technique | - |
dc.identifier.orcid | 0000-0002-0970-4288 | pt |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.