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DC Field | Value | Language |
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dc.contributor.author | Ribeiro, Daniele Lisboa | - |
dc.contributor.author | Pinto, Maria Etelvina | - |
dc.contributor.author | Maeda, Samantha Yuri | - |
dc.contributor.author | Taboga, Sebastiao Roberto | - |
dc.contributor.author | Goes, Rejane Maira | - |
dc.date.accessioned | 2014-05-20T14:01:06Z | - |
dc.date.accessioned | 2016-10-25T17:08:25Z | - |
dc.date.available | 2014-05-20T14:01:06Z | - |
dc.date.available | 2016-10-25T17:08:25Z | - |
dc.date.issued | 2012-08-01 | - |
dc.identifier | http://dx.doi.org/10.1007/s00441-012-1420-x | - |
dc.identifier.citation | Cell and Tissue Research. New York: Springer, v. 349, n. 2, p. 577-588, 2012. | - |
dc.identifier.issn | 0302-766X | - |
dc.identifier.uri | http://hdl.handle.net/11449/21591 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/21591 | - |
dc.description.abstract | Obesity affects sex hormone secretion, which can negatively influence prostatic structure, homeostasis, and disease. This investigation aimed to evaluate the repercussions of obesity induced by a high-fat diet on the rat prostate, with or without treatment with the aromatase inhibitor, Letrozole. Adult Wistar rats were fed a high-fat diet (20% saturated fat, O) for 15 weeks to induce obesity or received a balanced diet (4% fat, C). Then, a group of C and O rats were daily treated with Letrozole (1 mg/kg b.w. per day) for 2 weeks (CL and OL, respectively). Subsequently, ventral prostate was processed for analysis by transmission electron microscopy, immunohistochemistry, and Western blotting. Obesity decreased 70% of the testosterone plasma level. The prostate showed epithelial atrophy and dilated acini in the intermediate portion and epithelial wrinkling in the distal tips. The relative frequency of smooth muscle alpha-actin in the O group increased by 67%. Ultrastructurally, epithelial cells in obese animals presented altered secretory organelles, lipid droplets, and thicker subjacent fibromuscular layer. Letrozole treatment caused a partial restoration of the prostatic changes caused by obesity. Obesity increased the prostatic content of fibroblast growth factor-2 (FGF-2) by 150%, and Letrozole treatment increased this protein even more in the control and obese groups. This investigation shows that obesity provokes structural and ultrastructural changes in the epithelium of rat prostate; these changes might affect gland homeostasis and physiology. The epithelial and smooth muscle cell hyperplasia and increased FGF-2 expression observed in this experimental model of obesity/insulin-resistance might explain the high frequency of benign prostatic hyperplasia in insulin-resistant men. | en |
dc.format.extent | 577-588 | - |
dc.language.iso | eng | - |
dc.publisher | Springer | - |
dc.source | Web of Science | - |
dc.subject | Prostate | en |
dc.subject | Obesity | en |
dc.subject | Smooth muscle cells | en |
dc.subject | Benign prostatic hyperplasia | en |
dc.subject | Fibroblast growth factor | en |
dc.subject | Rat (Wistar) | en |
dc.title | High fat-induced obesity associated with insulin-resistance increases FGF-2 content and causes stromal hyperplasia in rat ventral prostate | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Universidade Federal de Uberlândia (UFU) | - |
dc.description.affiliation | IBILCE Unesp, Dept Biol, BR-15054000 São Paulo, Brazil | - |
dc.description.affiliation | Fed Univ Uberlandia UFU, Inst Biomed Sci, Dept Histol, Uberlandia, MG, Brazil | - |
dc.description.affiliation | Univ Estadual Paulista UNESP, Dept Biol, Inst Biosci Letters & Exact Sci, São Paulo, Brazil | - |
dc.description.affiliationUnesp | IBILCE Unesp, Dept Biol, BR-15054000 São Paulo, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista UNESP, Dept Biol, Inst Biosci Letters & Exact Sci, São Paulo, Brazil | - |
dc.identifier.doi | 10.1007/s00441-012-1420-x | - |
dc.identifier.wos | WOS:000307401200015 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Cell and Tissue Research | - |
dc.identifier.orcid | 0000-0002-0970-4288 | pt |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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