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DC Field | Value | Language |
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dc.contributor.author | Fazza, Ana Cristina | - |
dc.contributor.author | Sabino, Flavia Cal | - |
dc.contributor.author | Setta, Nathalia de | - |
dc.contributor.author | Bordin Jr., Newton Antonio | - |
dc.contributor.author | Silva, Eloiza Helena Tajara da | - |
dc.contributor.author | Carareto, Claudia Marcia Aparecida | - |
dc.date.accessioned | 2014-05-20T14:01:23Z | - |
dc.date.available | 2014-05-20T14:01:23Z | - |
dc.date.issued | 2009-01-01 | - |
dc.identifier | http://dx.doi.org/10.1590/S1415-47572009005000018 | - |
dc.identifier.citation | Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 32, n. 1, p. 25-31, 2009. | - |
dc.identifier.issn | 1415-4757 | - |
dc.identifier.uri | http://hdl.handle.net/11449/21672 | - |
dc.description.abstract | Alu-PCR is a relatively simple technique that can be used to investigate genomic instability in cancer. This technique allows identification of the loss, gain or amplification of gene sequences based on the analysis of segments between two Alu elements coupled with quantitative and qualitative analyses of the profiles obtained from tumor samples, surgical margins and blood. In this work, we used Alu-PCR to identify gene alterations in ten patients with invasive ductal breast cancer. Several deletions and insertions were identified, indicating genomic instability in the tumor and adjacent normal tissue. Although not associated with specific genes, the alterations, which involved chromosomal bands 1p36.23, 1q41, 11q14.3, 13q14.2, occurred in areas of well-known genomic instability in breast and other types of cancer. These results indicate the potential usefulness of Alu-PCR in identifying altered gene sequences in breast cancer. However, caution is required in its application since the Alu primer can produce non-specific amplification. | en |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.format.extent | 25-31 | - |
dc.language.iso | eng | - |
dc.publisher | Sociedade Brasileira de Genética | - |
dc.source | SciELO | - |
dc.subject | Alu-PCR | en |
dc.subject | Breast cancer | en |
dc.subject | gene insertions | en |
dc.subject | gene deletions | en |
dc.subject | invasive ductal carcinoma | en |
dc.subject | recombination | en |
dc.title | Estimating genomic instability mediated by Alu retroelements in breast cancer | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Faculdade de Medicina Departamento de Ginecologia e Obstetrícia | - |
dc.contributor.institution | Faculdade de Medicina Departamento de Biologia Molecular | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.description.affiliation | Universidade Estadual Paulista Júlio de Mesquita Filho Instituto de Biociências, Letras e Ciências Exatas Departamento de Biologia | - |
dc.description.affiliation | Faculdade de Medicina Departamento de Ginecologia e Obstetrícia | - |
dc.description.affiliation | Faculdade de Medicina Departamento de Biologia Molecular | - |
dc.description.affiliation | Universidade de São Paulo Instituto de Biociências Departamento de Genética e Biologia Evolucionária | - |
dc.description.affiliationUnesp | Universidade Estadual Paulista Júlio de Mesquita Filho Instituto de Biociências, Letras e Ciências Exatas Departamento de Biologia | - |
dc.description.sponsorshipId | CNPq: 304886/2006-8 | - |
dc.description.sponsorshipId | CNPq: 302421/2003-3 | - |
dc.description.sponsorshipId | CNPq: 108438/2004 | - |
dc.identifier.doi | 10.1590/S1415-47572009005000018 | - |
dc.identifier.scielo | S1415-47572009000100004 | - |
dc.identifier.wos | WOS:000263377700004 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | S1415-47572009000100004.pdf | - |
dc.relation.ispartof | Genetics and Molecular Biology | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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