You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/22044
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSilva Junior, Eufranio N. da-
dc.contributor.authorMelo, Isadora M. M. de-
dc.contributor.authorDiogo, Emilay B. T.-
dc.contributor.authorCosta, Verenice A.-
dc.contributor.authorSouza Filho, Jose D. de-
dc.contributor.authorValenca, Wagner O.-
dc.contributor.authorCamara, Celso A.-
dc.contributor.authorOliveira, Ronaldo N. de-
dc.contributor.authorAraujo, Alexandre S. de-
dc.contributor.authorEmery, Flavio S.-
dc.contributor.authorSantos, Marcelo R. dos-
dc.contributor.authorSimone, Carlos A. de-
dc.contributor.authorMenna-Barreto, Rubem F. S.-
dc.contributor.authorCastro, Solange L. de-
dc.date.accessioned2014-05-20T14:02:32Z-
dc.date.accessioned2016-10-25T17:09:10Z-
dc.date.available2014-05-20T14:02:32Z-
dc.date.available2016-10-25T17:09:10Z-
dc.date.issued2012-06-01-
dc.identifierhttp://dx.doi.org/10.1016/j.ejmech.2012.03.039-
dc.identifier.citationEuropean Journal of Medicinal Chemistry. Paris: Elsevier B.V., v. 52, p. 304-312, 2012.-
dc.identifier.issn0223-5234-
dc.identifier.urihttp://hdl.handle.net/11449/22044-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/22044-
dc.description.abstractFive 2-hydroxy-3-substituted-aminomethyl naphthoquinones, nine 1,2,3-triazolic para-naphthoquinones, five nor-beta-lapachone-based 1,2,3-triazoles, and several other naphthoquinonoid compounds were synthesized and evaluated against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease, continuing our screening program for new trypanocidal compounds. Among all the substances, 16-18, 23, 25-29 and 30-33 were herein described for the first time and fifteen substances were identified as more potent than the standard drug benznidazole, with IC50/24 h values in the range of 10.9-101.5 mu M. Compounds 14 and 19 with Selectivity Index of 18.9 and 6.1 are important structures for further studies. (C) 2012 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipFundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)-
dc.description.sponsorshipINCT_if-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.format.extent304-312-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectNaphthoquinonesen
dc.subjectLapacholen
dc.subjectChagas diseaseen
dc.subjectTrypanosoma cruzien
dc.subjectChemotherapyen
dc.titleOn the search for potential anti-Trypanosoma cruzi drugs: Synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry reactionsen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)-
dc.contributor.institutionUniversidade Federal Rural de Pernambuco (UFRPE)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade de Brasília (UnB)-
dc.contributor.institutionFiocruz MS-
dc.description.affiliationUniversidade Federal de Minas Gerais (UFMG), Lab Quim Sintet & Heterocicl, Inst Ciencias Exatas, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil-
dc.description.affiliationUniversidade Federal Rural de Pernambuco (UFRPE), Dept Ciencias Mol, BR-52171900 Recife, PE, Brazil-
dc.description.affiliationUNESP, Inst Biociencias Letras & Ciencias Exatas Sao Jos, Dept Fis, BR-15054000 Sao Jose do Rio Preto, SP, Brazil-
dc.description.affiliationUniv São Paulo, Fac Ciencias Farmaceut, BR-14040903 São Paulo, Brazil-
dc.description.affiliationUniversidade de Brasilia (UnB), Inst Quim, BR-70910970 Brasilia, DF, Brazil-
dc.description.affiliationUniv São Paulo, Dept Fis & Informat, Inst Fis, BR-13560160 São Carlos, SP, Brazil-
dc.description.affiliationFiocruz MS, Lab Biol Celular, Inst Oswaldo Cruz, BR-21045900 Rio de Janeiro, RJ, Brazil-
dc.description.affiliationUnespUNESP, Inst Biociencias Letras & Ciencias Exatas Sao Jos, Dept Fis, BR-15054000 Sao Jose do Rio Preto, SP, Brazil-
dc.description.sponsorshipIdFAPEMIG: APQ-04166-10-
dc.description.sponsorshipIdFAPESP: 09/14184-0-
dc.description.sponsorshipIdFAPESP: 09/51812-0-
dc.description.sponsorshipIdPRONEM-FACEPE: APQ-232106/10-
dc.description.sponsorshipIdFAPERJ: E-26/110.574/2010-
dc.description.sponsorshipIdFAPERJ: 101.579/2010-
dc.identifier.doi10.1016/j.ejmech.2012.03.039-
dc.identifier.wosWOS:000304291600030-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofEuropean Journal of Medicinal Chemistry-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.