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DC Field | Value | Language |
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dc.contributor.author | Silva Junior, Eufranio N. da | - |
dc.contributor.author | Melo, Isadora M. M. de | - |
dc.contributor.author | Diogo, Emilay B. T. | - |
dc.contributor.author | Costa, Verenice A. | - |
dc.contributor.author | Souza Filho, Jose D. de | - |
dc.contributor.author | Valenca, Wagner O. | - |
dc.contributor.author | Camara, Celso A. | - |
dc.contributor.author | Oliveira, Ronaldo N. de | - |
dc.contributor.author | Araujo, Alexandre S. de | - |
dc.contributor.author | Emery, Flavio S. | - |
dc.contributor.author | Santos, Marcelo R. dos | - |
dc.contributor.author | Simone, Carlos A. de | - |
dc.contributor.author | Menna-Barreto, Rubem F. S. | - |
dc.contributor.author | Castro, Solange L. de | - |
dc.date.accessioned | 2014-05-20T14:02:32Z | - |
dc.date.accessioned | 2016-10-25T17:09:10Z | - |
dc.date.available | 2014-05-20T14:02:32Z | - |
dc.date.available | 2016-10-25T17:09:10Z | - |
dc.date.issued | 2012-06-01 | - |
dc.identifier | http://dx.doi.org/10.1016/j.ejmech.2012.03.039 | - |
dc.identifier.citation | European Journal of Medicinal Chemistry. Paris: Elsevier B.V., v. 52, p. 304-312, 2012. | - |
dc.identifier.issn | 0223-5234 | - |
dc.identifier.uri | http://hdl.handle.net/11449/22044 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/22044 | - |
dc.description.abstract | Five 2-hydroxy-3-substituted-aminomethyl naphthoquinones, nine 1,2,3-triazolic para-naphthoquinones, five nor-beta-lapachone-based 1,2,3-triazoles, and several other naphthoquinonoid compounds were synthesized and evaluated against the infective bloodstream form of Trypanosoma cruzi, the etiological agent of Chagas disease, continuing our screening program for new trypanocidal compounds. Among all the substances, 16-18, 23, 25-29 and 30-33 were herein described for the first time and fifteen substances were identified as more potent than the standard drug benznidazole, with IC50/24 h values in the range of 10.9-101.5 mu M. Compounds 14 and 19 with Selectivity Index of 18.9 and 6.1 are important structures for further studies. (C) 2012 Elsevier B.V. All rights reserved. | en |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) | - |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco (FACEPE) | - |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) | - |
dc.description.sponsorship | INCT_if | - |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
dc.format.extent | 304-312 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.subject | Naphthoquinones | en |
dc.subject | Lapachol | en |
dc.subject | Chagas disease | en |
dc.subject | Trypanosoma cruzi | en |
dc.subject | Chemotherapy | en |
dc.title | On the search for potential anti-Trypanosoma cruzi drugs: Synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry reactions | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Federal de Minas Gerais (UFMG) | - |
dc.contributor.institution | Universidade Federal Rural de Pernambuco (UFRPE) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.contributor.institution | Universidade de Brasília (UnB) | - |
dc.contributor.institution | Fiocruz MS | - |
dc.description.affiliation | Universidade Federal de Minas Gerais (UFMG), Lab Quim Sintet & Heterocicl, Inst Ciencias Exatas, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil | - |
dc.description.affiliation | Universidade Federal Rural de Pernambuco (UFRPE), Dept Ciencias Mol, BR-52171900 Recife, PE, Brazil | - |
dc.description.affiliation | UNESP, Inst Biociencias Letras & Ciencias Exatas Sao Jos, Dept Fis, BR-15054000 Sao Jose do Rio Preto, SP, Brazil | - |
dc.description.affiliation | Univ São Paulo, Fac Ciencias Farmaceut, BR-14040903 São Paulo, Brazil | - |
dc.description.affiliation | Universidade de Brasilia (UnB), Inst Quim, BR-70910970 Brasilia, DF, Brazil | - |
dc.description.affiliation | Univ São Paulo, Dept Fis & Informat, Inst Fis, BR-13560160 São Carlos, SP, Brazil | - |
dc.description.affiliation | Fiocruz MS, Lab Biol Celular, Inst Oswaldo Cruz, BR-21045900 Rio de Janeiro, RJ, Brazil | - |
dc.description.affiliationUnesp | UNESP, Inst Biociencias Letras & Ciencias Exatas Sao Jos, Dept Fis, BR-15054000 Sao Jose do Rio Preto, SP, Brazil | - |
dc.description.sponsorshipId | FAPEMIG: APQ-04166-10 | - |
dc.description.sponsorshipId | FAPESP: 09/14184-0 | - |
dc.description.sponsorshipId | FAPESP: 09/51812-0 | - |
dc.description.sponsorshipId | PRONEM-FACEPE: APQ-232106/10 | - |
dc.description.sponsorshipId | FAPERJ: E-26/110.574/2010 | - |
dc.description.sponsorshipId | FAPERJ: 101.579/2010 | - |
dc.identifier.doi | 10.1016/j.ejmech.2012.03.039 | - |
dc.identifier.wos | WOS:000304291600030 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | European Journal of Medicinal Chemistry | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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