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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/22097
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dc.contributor.authorBessa Ramos, Jose Esio-
dc.contributor.authorRuggiero Neto, Joao-
dc.contributor.authorde Vries, Renko-
dc.date.accessioned2014-05-20T14:02:41Z-
dc.date.available2014-05-20T14:02:41Z-
dc.date.issued2008-11-14-
dc.identifierhttp://dx.doi.org/10.1063/1.2998521-
dc.identifier.citationJournal of Chemical Physics. Melville: Amer Inst Physics, v. 129, n. 18, p. 6, 2008.-
dc.identifier.issn0021-9606-
dc.identifier.urihttp://hdl.handle.net/11449/22097-
dc.description.abstractMacromolecular crowding is thought to be a significant factor driving DNA condensation in prokaryotic cells. Whereas DNA in prokaryotes is supercoiled, studies on crowding-induced DNA condensation have so far focused on linear DNA. Here we compare DNA condensation by poly(ethylene oxide) for supercoiled and linearized pUC18 plasmid DNA. It is found that supercoiling has only a limited influence on the critical amount of PEO needed to condense plasmid DNA. In order to pack DNA supercoils in condensates, it seems inevitable that they must be deformed in one way or another, to facilitate dense packing of DNA. Analytical estimates and Monte Carlo simulations indicate that packing of DNA supercoils in condensates is most likely facilitated by a decrease of the superhelical diameter rather than by unwinding of the supercoils.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.format.extent6-
dc.language.isoeng-
dc.publisherAmerican Institute of Physics (AIP)-
dc.sourceWeb of Science-
dc.subjectaggregationen
dc.subjectbiochemistryen
dc.subjectcellular biophysicsen
dc.subjectDNAen
dc.subjectMolecular biophysicsen
dc.subjectmolecular configurationsen
dc.subjectMonte Carlo methodsen
dc.subjectPolymersen
dc.titlePolymer induced condensation of DNA supercoilsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionWageningen Univ-
dc.description.affiliationUniv Estadual Paulista, Dept Phys, IBILCE UNESP, BR-15054000 Sao Jose do Rio Preto, SP, Brazil-
dc.description.affiliationWageningen Univ, Lab Phys Chem & Colloid Sci, NL-6700 EK Wageningen, Netherlands-
dc.description.affiliationUnespUniv Estadual Paulista, Dept Phys, IBILCE UNESP, BR-15054000 Sao Jose do Rio Preto, SP, Brazil-
dc.identifier.doi10.1063/1.2998521-
dc.identifier.wosWOS:000260944300053-
dc.rights.accessRightsAcesso restrito-
dc.identifier.fileWOS000260944300053.pdf-
dc.relation.ispartofJournal of Chemical Physics-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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