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DC Field | Value | Language |
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dc.contributor.author | Coronado, Monika A. | - |
dc.contributor.author | Georgieva, Dessislava | - |
dc.contributor.author | Buck, Friedrich | - |
dc.contributor.author | Gabdoulkhakov, Azat H. | - |
dc.contributor.author | Ullah, Anwar | - |
dc.contributor.author | Spencer, Patrick J. | - |
dc.contributor.author | Arni, Raghuvir K. | - |
dc.contributor.author | Betzel, Christian | - |
dc.date.accessioned | 2014-05-20T14:02:42Z | - |
dc.date.available | 2014-05-20T14:02:42Z | - |
dc.date.issued | 2012-09-01 | - |
dc.identifier | http://dx.doi.org/10.1107/S1744309112032721 | - |
dc.identifier.citation | Acta Crystallographica Section F-structural Biology and Crystallization Communications. Hoboken: Wiley-blackwell, v. 68, p. 1052-1054, 2012. | - |
dc.identifier.issn | 1744-3091 | - |
dc.identifier.uri | http://hdl.handle.net/11449/22104 | - |
dc.description.abstract | Crotamine, a highly basic myotoxic polypeptide (molecular mass 4881 Da) isolated from the venom of the Brazilian rattlesnake Crotalus durissus terrificus, causes skeletal muscle contraction and spasms, affects the functioning of voltage-sensitive sodium channels by inducing sodium influx and possesses antitumour activity, suggesting potential pharmaceutical applications. Crotamine was purified from C. durissus terrificus venom; the crystals diffracted to 1.9 angstrom resolution and belonged to the orthorhombic space group I212121 or I222, with unit-cell parameters a = 67.75, b = 74.4, c = 81.01 angstrom. The self-rotation function indicated that the asymmetric unit contained three molecules. However, structure determination by molecular replacement using NMR-determined coordinates was unsuccessful and a search for potential derivatives has been initiated. | en |
dc.description.sponsorship | Deutsche Forschungsgemeinschaft (DFG) | - |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
dc.description.sponsorship | Deutscher Akademischer Austauschdienst (DAAD) | - |
dc.description.sponsorship | Alexander von Humboldt Foundation | - |
dc.format.extent | 1052-1054 | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-Blackwell | - |
dc.source | Web of Science | - |
dc.subject | crotamine | en |
dc.subject | myotoxins | en |
dc.subject | Crotalus durissus terrificus | en |
dc.title | Purification, crystallization and preliminary X-ray diffraction analysis of crotamine, a myotoxic polypeptide from the Brazilian snake Crotalus durissus terrificus | en |
dc.type | outro | - |
dc.contributor.institution | Univ Hamburg | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Univ Med Ctr Hamburg Eppendorf | - |
dc.contributor.institution | Russian Acad Sci | - |
dc.contributor.institution | Instituto de Pesquisas Energéticas e Nucleares (IPEN) | - |
dc.description.affiliation | Univ Hamburg, DESY, Lab Struct Biol Infect & Inflammat, D-22603 Hamburg, Germany | - |
dc.description.affiliation | Univ Estadual Paulista UNESP, Dept Fis, Ctr Multiusuario Inovacao Biomol, BR-15054000 Sao Jose do Rio Preto, SP, Brazil | - |
dc.description.affiliation | Univ Med Ctr Hamburg Eppendorf, Inst Clin Chem, D-20246 Hamburg, Germany | - |
dc.description.affiliation | Russian Acad Sci, Inst Crystallog, Moscow 119333, Russia | - |
dc.description.affiliation | Inst Pesquisas Energet & Nucl CNEN SP, Ctr Biotecnol, BR-05508000 São Paulo, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista UNESP, Dept Fis, Ctr Multiusuario Inovacao Biomol, BR-15054000 Sao Jose do Rio Preto, SP, Brazil | - |
dc.description.sponsorshipId | DFG: BE 1443-18-1 | - |
dc.description.sponsorshipId | CAPES: 80563/2911 | - |
dc.description.sponsorshipId | DAAD: PROBAL 50754442 | - |
dc.description.sponsorshipId | Alexander von Humboldt Foundation, Bonn, Germany: 3.3-BUL/1073481 STP | - |
dc.identifier.doi | 10.1107/S1744309112032721 | - |
dc.identifier.wos | WOS:000308407200011 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.identifier.file | WOS000308407200011.pdf | - |
dc.relation.ispartof | Acta Crystallographica Section F: Structural Biology and Crystallization Communications | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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