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dc.contributor.authorCoronado, Monika A.-
dc.contributor.authorGeorgieva, Dessislava-
dc.contributor.authorBuck, Friedrich-
dc.contributor.authorGabdoulkhakov, Azat H.-
dc.contributor.authorUllah, Anwar-
dc.contributor.authorSpencer, Patrick J.-
dc.contributor.authorArni, Raghuvir K.-
dc.contributor.authorBetzel, Christian-
dc.date.accessioned2014-05-20T14:02:42Z-
dc.date.available2014-05-20T14:02:42Z-
dc.date.issued2012-09-01-
dc.identifierhttp://dx.doi.org/10.1107/S1744309112032721-
dc.identifier.citationActa Crystallographica Section F-structural Biology and Crystallization Communications. Hoboken: Wiley-blackwell, v. 68, p. 1052-1054, 2012.-
dc.identifier.issn1744-3091-
dc.identifier.urihttp://hdl.handle.net/11449/22104-
dc.description.abstractCrotamine, a highly basic myotoxic polypeptide (molecular mass 4881 Da) isolated from the venom of the Brazilian rattlesnake Crotalus durissus terrificus, causes skeletal muscle contraction and spasms, affects the functioning of voltage-sensitive sodium channels by inducing sodium influx and possesses antitumour activity, suggesting potential pharmaceutical applications. Crotamine was purified from C. durissus terrificus venom; the crystals diffracted to 1.9 angstrom resolution and belonged to the orthorhombic space group I212121 or I222, with unit-cell parameters a = 67.75, b = 74.4, c = 81.01 angstrom. The self-rotation function indicated that the asymmetric unit contained three molecules. However, structure determination by molecular replacement using NMR-determined coordinates was unsuccessful and a search for potential derivatives has been initiated.en
dc.description.sponsorshipDeutsche Forschungsgemeinschaft (DFG)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipDeutscher Akademischer Austauschdienst (DAAD)-
dc.description.sponsorshipAlexander von Humboldt Foundation-
dc.format.extent1052-1054-
dc.language.isoeng-
dc.publisherWiley-Blackwell-
dc.sourceWeb of Science-
dc.subjectcrotamineen
dc.subjectmyotoxinsen
dc.subjectCrotalus durissus terrificusen
dc.titlePurification, crystallization and preliminary X-ray diffraction analysis of crotamine, a myotoxic polypeptide from the Brazilian snake Crotalus durissus terrificusen
dc.typeoutro-
dc.contributor.institutionUniv Hamburg-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Med Ctr Hamburg Eppendorf-
dc.contributor.institutionRussian Acad Sci-
dc.contributor.institutionInstituto de Pesquisas Energéticas e Nucleares (IPEN)-
dc.description.affiliationUniv Hamburg, DESY, Lab Struct Biol Infect & Inflammat, D-22603 Hamburg, Germany-
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Fis, Ctr Multiusuario Inovacao Biomol, BR-15054000 Sao Jose do Rio Preto, SP, Brazil-
dc.description.affiliationUniv Med Ctr Hamburg Eppendorf, Inst Clin Chem, D-20246 Hamburg, Germany-
dc.description.affiliationRussian Acad Sci, Inst Crystallog, Moscow 119333, Russia-
dc.description.affiliationInst Pesquisas Energet & Nucl CNEN SP, Ctr Biotecnol, BR-05508000 São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Fis, Ctr Multiusuario Inovacao Biomol, BR-15054000 Sao Jose do Rio Preto, SP, Brazil-
dc.description.sponsorshipIdDFG: BE 1443-18-1-
dc.description.sponsorshipIdCAPES: 80563/2911-
dc.description.sponsorshipIdDAAD: PROBAL 50754442-
dc.description.sponsorshipIdAlexander von Humboldt Foundation, Bonn, Germany: 3.3-BUL/1073481 STP-
dc.identifier.doi10.1107/S1744309112032721-
dc.identifier.wosWOS:000308407200011-
dc.rights.accessRightsAcesso restrito-
dc.identifier.fileWOS000308407200011.pdf-
dc.relation.ispartofActa Crystallographica Section F: Structural Biology and Crystallization Communications-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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