You are in the accessibility menu

Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDecock, Julie-
dc.contributor.authorLong, Ji-Rong-
dc.contributor.authorLaxton, Ross C.-
dc.contributor.authorShu, Xiao-Ou-
dc.contributor.authorHodgkinson, Conrad-
dc.contributor.authorHendrickx, Wouter-
dc.contributor.authorPearce, Eve G.-
dc.contributor.authorGao, Yu-Tang-
dc.contributor.authorPereira, Andresa C.-
dc.contributor.authorParidaens, Robert-
dc.contributor.authorZheng, Wei-
dc.contributor.authorYe, Shu-
dc.identifier.citationCancer Research. Philadelphia: Amer Associação Cancer Research, v. 67, n. 21, p. 10214-10221, 2007.-
dc.description.abstractAnimal and cell studies indicate an inhibitory effect of matrix metalloproteinase-8 (MMP8) on tumorigenesis and metastasis. We investigated whether MMP8 gene variation was associated with breast cancer metastasis and prognosis in humans. We first studied nine tagging single nucleotide polymorphisms (SNP) in the MMP8 gene in 140 clinically and pathologically well-characterized breast cancer patients. Four of the SNPs were found to be associated with lymph node metastasis, the most pronounced being a promoter SNP (rs11225395) with its minor allele (T) associating with reduced susceptibility to lymph node metastasis (P = 0.02). This SNP was further evaluated for association with cancer relapse and survival among a cohort of similar to 1,100 breast cancer patients who had been followed for cancer recurrence and mortality for a median of 7.1 years. The T allele was associated with reduced cancer relapse and greater survival, particularly among patients with earlier stage cancer. Among patients of tumor-node-metastasis stage 0 to 11, the adjusted hazard ratio of disease-free survival was 0.7 [95% confidence interval (95% CI), 0.5-0.9] for patients carrying T allele compared with those homozygous for the C allele (P = 0.02). In vitro experiments showed that the T allele had higher promoter activity than the C allele in breast cancer cells. Electrophoretic mobility shift assays showed binding of nuclear proteins to the DNA sequence at the SNP site of the T allele but not that of the C allele. The data suggest that MMP8 gene variation may influence breast cancer prognosis and support the notion that MMP8 has an inhibitory effect on cancer metastasis.en
dc.publisherAmerican Association for Cancer Research (AACR)-
dc.sourceWeb of Science-
dc.titleAssociation of matrix metalloproteinase-8 gene variation with breast cancer prognosisen
dc.contributor.institutionUniv London-
dc.contributor.institutionUniv Hosp Gasthuisberg-
dc.contributor.institutionUniv Southampton-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionVanderbilt Univ-
dc.contributor.institutionShanghai Canc Inst-
dc.description.affiliationUniv London, Barts & London Sch Med, William Harvey Res Inst, London EC1M 6BQ, England-
dc.description.affiliationUniv Hosp Gasthuisberg, Dept Gen Med Oncol, Expt Oncol Lab, B-3000 Louvain, Belgium-
dc.description.affiliationUniv Southampton, Sch Med, Div Human Genet, Southampton, Hants, England-
dc.description.affiliationUniv Estadual Paulista, Fac Odontol Sao Jose Campos, Dept Biociencias & Diagnost, Bucal, Brazil-
dc.description.affiliationVanderbilt Univ, Sch Med, Vanderbilt Ingram Canc Ctr, Vanderbilt Epidemiol Ctr,Dept Med, Nashville, TN 37212 USA-
dc.description.affiliationShanghai Canc Inst, Dept Epidemiol, Shanghai, Peoples R China-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Odontol Sao Jose Campos, Dept Biociencias & Diagnost, Bucal, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofCancer Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.