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http://acervodigital.unesp.br/handle/11449/22608
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DC Field | Value | Language |
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dc.contributor.author | Branco-de-Almeida, Luciana S. | - |
dc.contributor.author | Franco, Gilson C. | - |
dc.contributor.author | Castro, Myrella L. | - |
dc.contributor.author | dos Santos, Juliana G. | - |
dc.contributor.author | Anbinder, Ana Lia | - |
dc.contributor.author | Cortelli, Sheila C. | - |
dc.contributor.author | Kajiya, Mikihito | - |
dc.contributor.author | Kawai, Toshihisa | - |
dc.contributor.author | Rosalen, Pedro L. | - |
dc.date.accessioned | 2014-05-20T14:04:26Z | - |
dc.date.accessioned | 2016-10-25T17:10:11Z | - |
dc.date.available | 2014-05-20T14:04:26Z | - |
dc.date.available | 2016-10-25T17:10:11Z | - |
dc.date.issued | 2012-05-01 | - |
dc.identifier | http://dx.doi.org/10.1902/jop.2011.110370 | - |
dc.identifier.citation | Journal of Periodontology. Chicago: Amer Acad Periodontology, v. 83, n. 5, p. 664-671, 2012. | - |
dc.identifier.issn | 0022-3492 | - |
dc.identifier.uri | http://hdl.handle.net/11449/22608 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/22608 | - |
dc.description.abstract | Background: Fluoxetine, a selective serotonin reuptake inhibitor, has been found recently to possess anti-inflammatory properties. The present study investigates the effects of fluoxetine on inflammatory tissue destruction in a rat model of ligature-induced periodontal disease.Methods: Thirty male Wistar rats were randomly assigned into three groups (n = 10 animals per group): 1) control rats (without ligature); 2) rats with ligature + placebo (saline; oral gavage); and 3) rats with ligature + fluoxetine (20 mg/kg/day in saline; oral gavage). Histologic analyses were performed on the furcation region and mesial aspect of mandibular first molars of rats sacrificed at 15 days after ligature-induced periodontal disease. Reverse transcription-polymerase chain reaction and zymography were performed to analyze the mRNA expression of interleukin (IL)-1 beta, cyclooxygenase (COX)-2, matrix metalloproteinase (MMP)-9 and inducible nitric oxide synthase and the MMP-9 activity, respectively, in gingival tissues samples.Results: Compared to the ligature + placebo group, alveolar bone loss was reduced in the fluoxetine group (P <0.05), and the amount of collagen fibers in the gingival tissue was maintained. Moreover, in gingival tissue sampled 3 days after ligature attachment, fluoxetine administration reduced IL-1 beta and COX-2 mRNA expression. Fluoxetine downregulated MMP-9 activity, without affecting MMP-9 mRNA expression induced by ligature, compared to the ligature + placebo group (P <0.05). These data suggest that fluoxetine suppressed proinflammatory responses, as well as proteolytic enzyme activity, induced by ligature.Conclusion: In the present study, fluoxetine suppresses the inflammatory response and protects against periodontal bone resorption and destruction of collagen fibers, suggesting that fluoxetine can constitute a promising therapeutic approach for periodontal diseases. J Periodontol 2012;83:664-671. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
dc.description.sponsorship | National Institutes of Health/National Institute of Dental and Craniofacial Research | - |
dc.format.extent | 664-671 | - |
dc.language.iso | eng | - |
dc.publisher | Amer Acad Periodontology | - |
dc.source | Web of Science | - |
dc.subject | Bone resorption | en |
dc.subject | collagen | en |
dc.subject | fluoxetine | en |
dc.subject | inflammation | en |
dc.subject | periodontitis | en |
dc.title | Fluoxetine Inhibits Inflammatory Response and Bone Loss in a Rat Model of Ligature-Induced Periodontitis | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual de Campinas (UNICAMP) | - |
dc.contributor.institution | Univ Taubate | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Forsyth Inst | - |
dc.contributor.institution | Harvard Univ | - |
dc.description.affiliation | Univ Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, BR-13414903 Piracicaba, SP, Brazil | - |
dc.description.affiliation | Univ Taubate, Dept Oral Biol, São Paulo, Brazil | - |
dc.description.affiliation | Univ Estadual Paulista UNESP, Sch Dent Sao Jose dos Campos, Dept Biosci & Oral Diag, São Paulo, Brazil | - |
dc.description.affiliation | Forsyth Inst, Dept Immunol, Cambridge, MA USA | - |
dc.description.affiliation | Harvard Univ, Sch Dent Med, Dept Oral Med Infect & Immun, Boston, MA 02115 USA | - |
dc.description.affiliationUnesp | Univ Estadual Paulista UNESP, Sch Dent Sao Jose dos Campos, Dept Biosci & Oral Diag, São Paulo, Brazil | - |
dc.description.sponsorshipId | FAPESP: 08/00566-6 | - |
dc.description.sponsorshipId | CAPES: 4073/08-8 | - |
dc.description.sponsorshipId | NIH/NIDCR: DE-018499 | - |
dc.description.sponsorshipId | NIH/NIDCR: DE-019917 | - |
dc.identifier.doi | 10.1902/jop.2011.110370 | - |
dc.identifier.wos | WOS:000303641300016 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Journal of Periodontology | - |
dc.identifier.orcid | 0000-0003-3930-4274 | pt |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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