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http://acervodigital.unesp.br/handle/11449/22642
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DC Field | Value | Language |
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dc.contributor.author | do Prado, Renata Falchete | - |
dc.contributor.author | da Silva Machado, Ana Lourdes | - |
dc.contributor.author | Dias Colombo, Carlos Eduardo | - |
dc.contributor.author | Carvalho, Yasmin Rodarte | - |
dc.date.accessioned | 2014-05-20T14:04:32Z | - |
dc.date.accessioned | 2016-10-25T17:10:15Z | - |
dc.date.available | 2014-05-20T14:04:32Z | - |
dc.date.available | 2016-10-25T17:10:15Z | - |
dc.date.issued | 2011-07-01 | - |
dc.identifier | http://dx.doi.org/10.1111/j.1600-0714.2011.01023.x | - |
dc.identifier.citation | Journal of Oral Pathology & Medicine. Malden: Wiley-blackwell, v. 40, n. 6, p. 467-475, 2011. | - |
dc.identifier.issn | 0904-2512 | - |
dc.identifier.uri | http://hdl.handle.net/11449/22642 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/22642 | - |
dc.description.abstract | BACKGROUND: The enzyme fatty acid synthase plays a fundamental role in the biosynthesis of fatty acids. Several recent studies have demonstrated a high fatty acid synthase expression in malignant tumors. Few studies have been conducted in oral and salivary gland tumors describing the fatty acid synthase expression.METHODS: This study evaluated and compared, by immunohistochemical reaction, the expression of fatty acid synthase and Ki-67 in salivary gland tumors. The immunohistochemical study used the streptavidin-biotin-peroxidase technique, with antibodies anti-fatty acid synthase and anti-Ki-67. The fatty acid synthase was analyzed by scores, considering the intensity of labeling, quantity of labeled cells and histological component. The Ki-67 was analyzed by counting of one thousand cells, calculating the quantity of positive cells in regions with higher density of labeling. Statistical analysis was performed using the Pearson and Mann-Whitney correlation tests.RESULTS: There was greater fatty acid synthase expression in pleomorphic adenoma compared to other tumors, and predominance of Ki-67 in malignant tumors. Among these, the mucoepidermoid carcinoma presented the highest proliferation rate. The expression of fatty acid synthase and Ki-67 did not present correlation between the tumors analyzed, except in pleomorphic adenomas, with statistically significant relationship between them.CONCLUSION: It is suggested that the fat metabolism in salivary gland tumors is related to maintenance of cell differentiation. Its expression prevailed in benign tumors, while Ki-67 prevailed in the mucoepidermoid carcinoma, demonstrating its high proliferation rate, followed by the cystic adenoid carcinoma and polymorphous low grade adenocarcinoma. J Oral Pathol Med (2011) 40: 467-475 | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.format.extent | 467-475 | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-Blackwell | - |
dc.source | Web of Science | - |
dc.subject | fatty acid synthase | en |
dc.subject | immunohistochemistry | en |
dc.subject | Ki-67 | en |
dc.subject | salivary gland tumors | en |
dc.title | Immunohistochemical study of the expression of fatty acid synthase and Ki-67 in salivary gland tumors | en |
dc.type | outro | - |
dc.contributor.institution | Super Sch Cruzeiro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Univ Taubate | - |
dc.description.affiliation | Super Sch Cruzeiro, Dept Physiotherapy, BR-12245000 São Paulo, Brazil | - |
dc.description.affiliation | São Paulo State Univ, Sao Jose dos Campos Dent Sch, Dept Biosci & Oral Diag, São Paulo, Brazil | - |
dc.description.affiliation | Univ Taubate, Dept Dent, São Paulo, Brazil | - |
dc.description.affiliationUnesp | São Paulo State Univ, Sao Jose dos Campos Dent Sch, Dept Biosci & Oral Diag, São Paulo, Brazil | - |
dc.description.sponsorshipId | FAPESP: 07/55604-7 | - |
dc.identifier.doi | 10.1111/j.1600-0714.2011.01023.x | - |
dc.identifier.wos | WOS:000292315600005 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Journal of Oral Pathology & Medicine | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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