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dc.contributor.authordo Prado, Renata Falchete-
dc.contributor.authorda Silva Machado, Ana Lourdes-
dc.contributor.authorDias Colombo, Carlos Eduardo-
dc.contributor.authorCarvalho, Yasmin Rodarte-
dc.identifier.citationJournal of Oral Pathology & Medicine. Malden: Wiley-blackwell, v. 40, n. 6, p. 467-475, 2011.-
dc.description.abstractBACKGROUND: The enzyme fatty acid synthase plays a fundamental role in the biosynthesis of fatty acids. Several recent studies have demonstrated a high fatty acid synthase expression in malignant tumors. Few studies have been conducted in oral and salivary gland tumors describing the fatty acid synthase expression.METHODS: This study evaluated and compared, by immunohistochemical reaction, the expression of fatty acid synthase and Ki-67 in salivary gland tumors. The immunohistochemical study used the streptavidin-biotin-peroxidase technique, with antibodies anti-fatty acid synthase and anti-Ki-67. The fatty acid synthase was analyzed by scores, considering the intensity of labeling, quantity of labeled cells and histological component. The Ki-67 was analyzed by counting of one thousand cells, calculating the quantity of positive cells in regions with higher density of labeling. Statistical analysis was performed using the Pearson and Mann-Whitney correlation tests.RESULTS: There was greater fatty acid synthase expression in pleomorphic adenoma compared to other tumors, and predominance of Ki-67 in malignant tumors. Among these, the mucoepidermoid carcinoma presented the highest proliferation rate. The expression of fatty acid synthase and Ki-67 did not present correlation between the tumors analyzed, except in pleomorphic adenomas, with statistically significant relationship between them.CONCLUSION: It is suggested that the fat metabolism in salivary gland tumors is related to maintenance of cell differentiation. Its expression prevailed in benign tumors, while Ki-67 prevailed in the mucoepidermoid carcinoma, demonstrating its high proliferation rate, followed by the cystic adenoid carcinoma and polymorphous low grade adenocarcinoma. J Oral Pathol Med (2011) 40: 467-475en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.sourceWeb of Science-
dc.subjectfatty acid synthaseen
dc.subjectsalivary gland tumorsen
dc.titleImmunohistochemical study of the expression of fatty acid synthase and Ki-67 in salivary gland tumorsen
dc.contributor.institutionSuper Sch Cruzeiro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Taubate-
dc.description.affiliationSuper Sch Cruzeiro, Dept Physiotherapy, BR-12245000 São Paulo, Brazil-
dc.description.affiliationSão Paulo State Univ, Sao Jose dos Campos Dent Sch, Dept Biosci & Oral Diag, São Paulo, Brazil-
dc.description.affiliationUniv Taubate, Dept Dent, São Paulo, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, Sao Jose dos Campos Dent Sch, Dept Biosci & Oral Diag, São Paulo, Brazil-
dc.description.sponsorshipIdFAPESP: 07/55604-7-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Oral Pathology & Medicine-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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