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dc.contributor.authorAro, Katri-
dc.contributor.authorRosa, Luiz Eduardo Blumer-
dc.contributor.authorBello, Ibrahim O.-
dc.contributor.authorSoini, Ylermi-
dc.contributor.authorMakitie, Antti A.-
dc.contributor.authorSalo, Tuula-
dc.contributor.authorLeivo, Ilmo-
dc.identifier.citationVirchows Archiv. New York: Springer, v. 458, n. 3, p. 341-348, 2011.-
dc.description.abstractClaudins (CLDNs) are a family of membrane proteins important for permeability of tight junctions. They have also been implicated in carcinogenesis and tumor progression. We analyzed patterns of distribution and intensity of expression of CLDNs 1, 3, 4, and 7 in mucoepidermoid carcinoma (MEC) of salivary gland in 39 patients. Correlations between the expression of CLDNs, tumor grade, and survival were explored. In immunohistochemical analysis, high expression of CLDN 1 was seen in low-grade MEC, and it appeared to be a suitable auxiliary marker of good prognosis. It classified MEC similarly to histological grading in 89.7% of cases (p=0.001). High CLDN 3 expression was seen in intermediate-and high-grade MEC, while it was low in low-grade MEC. CLDN 3 intensity correctly categorized tumors into grades in 71.8% of cases (p=0.017). However, in multivariate analysis CLDN 1 and CLDN 3 did not achieve significance over tumor grade in predicting patient behavior. We conclude that analysis of staining intensities of CLDN 1 and 3 is useful as an auxiliary diagnostic and prognostic tool in patients with salivary gland MEC.en
dc.description.sponsorshipFinnish Cancer Society-
dc.description.sponsorshipSpecial Government Funding (EVO) of Helsinki-
dc.description.sponsorshipKuopio and Oulu University Hospitals-
dc.description.sponsorshipFinnish Dental Society Apollonia-
dc.description.sponsorshipFinnish Lung Health Association (Filha)-
dc.description.sponsorshipMaritza and Reino Salonen Foundation-
dc.sourceWeb of Science-
dc.subjectTight junctionsen
dc.subjectMucoepidermoid carcinomaen
dc.subjectHead and necken
dc.subjectPrognostic markeren
dc.titleExpression pattern of claudins 1 and 3-an auxiliary tool in predicting behavior of mucoepidermoid carcinoma of salivary gland originen
dc.contributor.institutionUniv Helsinki-
dc.contributor.institutionUniv Turku-
dc.contributor.institutionUniv Oulu-
dc.contributor.institutionOulu Univ Hosp-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Eastern Finland-
dc.contributor.institutionKuopio Univ Hosp-
dc.description.affiliationUniv Helsinki, Dept Pathol, Haartman Inst, Helsinki, Finland-
dc.description.affiliationHUSLAB, Helsinki, Finland-
dc.description.affiliationUniv Turku, Dept Pathol, Turku, Finland-
dc.description.affiliationUniv Helsinki, Cent Hosp, Dept Otolaryngol Head & Neck Surg, Helsinki, Finland-
dc.description.affiliationUniv Oulu, Inst Dent, Dept Diagnost, Oulu, Finland-
dc.description.affiliationUniv Oulu, Inst Dent, Dept Oral Med, Oulu, Finland-
dc.description.affiliationOulu Univ Hosp, Oulu, Finland-
dc.description.affiliationUNESP, Sch Dent, Dept Biosci & Oral Diagnost, Sao Jose Dos Campos, Brazil-
dc.description.affiliationUniv Eastern Finland, Dept Clin Pathol & Forens Med, Kuopio, Finland-
dc.description.affiliationKuopio Univ Hosp, Dept Pathol, SF-70210 Kuopio, Finland-
dc.description.affiliationUnespUNESP, Sch Dent, Dept Biosci & Oral Diagnost, Sao Jose Dos Campos, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofVirchows Archiv-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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