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http://acervodigital.unesp.br/handle/11449/22644
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DC Field | Value | Language |
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dc.contributor.author | Aro, Katri | - |
dc.contributor.author | Rosa, Luiz Eduardo Blumer | - |
dc.contributor.author | Bello, Ibrahim O. | - |
dc.contributor.author | Soini, Ylermi | - |
dc.contributor.author | Makitie, Antti A. | - |
dc.contributor.author | Salo, Tuula | - |
dc.contributor.author | Leivo, Ilmo | - |
dc.date.accessioned | 2014-05-20T14:04:32Z | - |
dc.date.accessioned | 2016-10-25T17:10:15Z | - |
dc.date.available | 2014-05-20T14:04:32Z | - |
dc.date.available | 2016-10-25T17:10:15Z | - |
dc.date.issued | 2011-03-01 | - |
dc.identifier | http://dx.doi.org/10.1007/s00428-010-1026-1 | - |
dc.identifier.citation | Virchows Archiv. New York: Springer, v. 458, n. 3, p. 341-348, 2011. | - |
dc.identifier.issn | 0945-6317 | - |
dc.identifier.uri | http://hdl.handle.net/11449/22644 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/22644 | - |
dc.description.abstract | Claudins (CLDNs) are a family of membrane proteins important for permeability of tight junctions. They have also been implicated in carcinogenesis and tumor progression. We analyzed patterns of distribution and intensity of expression of CLDNs 1, 3, 4, and 7 in mucoepidermoid carcinoma (MEC) of salivary gland in 39 patients. Correlations between the expression of CLDNs, tumor grade, and survival were explored. In immunohistochemical analysis, high expression of CLDN 1 was seen in low-grade MEC, and it appeared to be a suitable auxiliary marker of good prognosis. It classified MEC similarly to histological grading in 89.7% of cases (p=0.001). High CLDN 3 expression was seen in intermediate-and high-grade MEC, while it was low in low-grade MEC. CLDN 3 intensity correctly categorized tumors into grades in 71.8% of cases (p=0.017). However, in multivariate analysis CLDN 1 and CLDN 3 did not achieve significance over tumor grade in predicting patient behavior. We conclude that analysis of staining intensities of CLDN 1 and 3 is useful as an auxiliary diagnostic and prognostic tool in patients with salivary gland MEC. | en |
dc.description.sponsorship | Finnish Cancer Society | - |
dc.description.sponsorship | Special Government Funding (EVO) of Helsinki | - |
dc.description.sponsorship | Kuopio and Oulu University Hospitals | - |
dc.description.sponsorship | Finnish Dental Society Apollonia | - |
dc.description.sponsorship | Finnish Lung Health Association (Filha) | - |
dc.description.sponsorship | Maritza and Reino Salonen Foundation | - |
dc.format.extent | 341-348 | - |
dc.language.iso | eng | - |
dc.publisher | Springer | - |
dc.source | Web of Science | - |
dc.subject | Claudin | en |
dc.subject | Tight junctions | en |
dc.subject | Mucoepidermoid carcinoma | en |
dc.subject | Immunohistochemistry | en |
dc.subject | Head and neck | en |
dc.subject | Prognostic marker | en |
dc.title | Expression pattern of claudins 1 and 3-an auxiliary tool in predicting behavior of mucoepidermoid carcinoma of salivary gland origin | en |
dc.type | outro | - |
dc.contributor.institution | Univ Helsinki | - |
dc.contributor.institution | HUSLAB | - |
dc.contributor.institution | Univ Turku | - |
dc.contributor.institution | Univ Oulu | - |
dc.contributor.institution | Oulu Univ Hosp | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Univ Eastern Finland | - |
dc.contributor.institution | Kuopio Univ Hosp | - |
dc.description.affiliation | Univ Helsinki, Dept Pathol, Haartman Inst, Helsinki, Finland | - |
dc.description.affiliation | HUSLAB, Helsinki, Finland | - |
dc.description.affiliation | Univ Turku, Dept Pathol, Turku, Finland | - |
dc.description.affiliation | Univ Helsinki, Cent Hosp, Dept Otolaryngol Head & Neck Surg, Helsinki, Finland | - |
dc.description.affiliation | Univ Oulu, Inst Dent, Dept Diagnost, Oulu, Finland | - |
dc.description.affiliation | Univ Oulu, Inst Dent, Dept Oral Med, Oulu, Finland | - |
dc.description.affiliation | Oulu Univ Hosp, Oulu, Finland | - |
dc.description.affiliation | UNESP, Sch Dent, Dept Biosci & Oral Diagnost, Sao Jose Dos Campos, Brazil | - |
dc.description.affiliation | Univ Eastern Finland, Dept Clin Pathol & Forens Med, Kuopio, Finland | - |
dc.description.affiliation | Kuopio Univ Hosp, Dept Pathol, SF-70210 Kuopio, Finland | - |
dc.description.affiliationUnesp | UNESP, Sch Dent, Dept Biosci & Oral Diagnost, Sao Jose Dos Campos, Brazil | - |
dc.identifier.doi | 10.1007/s00428-010-1026-1 | - |
dc.identifier.wos | WOS:000288679000010 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Virchows Archiv | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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