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dc.contributor.authorKurachi, Cristina-
dc.contributor.authorFontana, Carla R.-
dc.contributor.authorRosa, Luiz E. B.-
dc.contributor.authorBagnato, Vanderlei S.-
dc.identifier.citationJournal of Biomedical Optics. Bellingham: Spie-soc Photoptical Instrumentation Engineers, v. 13, n. 3, p. 6, 2008.-
dc.description.abstractThe efficacy of fluorescence spectroscopy to detect squamous cell carcinoma is evaluated in an animal model following laser excitation at 442 and 532 nm. Lesions are chemically induced with a topical DMBA application at the left lateral tongue of Golden Syrian hamsters. The animals are investigated every 2 weeks after the 4th week of induction until a total of 26 weeks. The right lateral tongue of each animal is considered as a control site (normal contralateral tissue) and the induced lesions are analyzed as a set of points covering the entire clinically detectable area. Based on fluorescence spectral differences, four indices are determined to discriminate normal and carcinoma tissues, based on intraspectral analysis. The spectral data are also analyzed using a multivariate data analysis and the results are compared with histology as the diagnostic gold standard. The best result achieved is for blue excitation using the KNN (K-nearest neighbor, a interspectral analysis) algorithm with a sensitivity of 95.7% and a specificity of 91.6%. These high indices indicate that fluorescence spectroscopy may constitute a fast noninvasive auxiliary tool for diagnostic of cancer within the oral cavity. (C) 2008 Society of Photo-Optical Instrumentation Engineers.en
dc.publisherSpie-soc Photoptical Instrumentation Engineers-
dc.sourceWeb of Science-
dc.subjectoptical detectionen
dc.subjectoral canceren
dc.titleFluorescence spectroscopy for the detection of tongue carcinoma - validation in an animal modelen
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv São Paulo, Inst Fis Sao Carlos, BR-13566590 São Paulo, Brazil-
dc.description.affiliationUniv Estadual Paulista, Fac Odontol, São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Odontol, São Paulo, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Biomedical Optics-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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