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dc.contributor.authorRegasini, Luis Octavio-
dc.contributor.authorRebuglio Vellosa, Jose Carlos-
dc.contributor.authorSiqueira Silva, Dulce Helena-
dc.contributor.authorFurlan, Maysa-
dc.contributor.authorMascarenhas de Oliveira, Olga Maria-
dc.contributor.authorKhalil, Najeh Maissar-
dc.contributor.authorBrunetti, Iguatemy Lourenço-
dc.contributor.authorMarx Young, Maria Claudia-
dc.contributor.authorBarreiro, Eliezer Jesus-
dc.contributor.authorBolzani, Vanderlan da Silva-
dc.date.accessioned2014-05-20T14:17:35Z-
dc.date.accessioned2016-10-25T17:40:02Z-
dc.date.available2014-05-20T14:17:35Z-
dc.date.available2016-10-25T17:40:02Z-
dc.date.issued2008-05-01-
dc.identifierhttp://dx.doi.org/10.1016/j.phytochem.2008.01.006-
dc.identifier.citationPhytochemistry. Oxford: Pergamon-Elsevier B.V. Ltd, v. 69, n. 8, p. 1739-1744, 2008.-
dc.identifier.issn0031-9422-
dc.identifier.urihttp://hdl.handle.net/11449/25268-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/25268-
dc.description.abstractA myeloperoxidase inhibitory kaempferol derivative, namely pterogynoside (1), was isolated from fruits of Pterogyne nitens, along with six known flavonols, kaempferol, afzelin, kaempferitrin, quercetin, isoquercetrin and rutin. The structures of all compounds were elucidated primarily from 1D and 2D NMR spectroscopic analyses, as well as by high resolution mass spectrometry. All flavonols were screened to identify secondary metabolites as potential myeloperoxidase (MPO) inhibitors, and at concentrations of 0.50-50 nM, quercetin (5), isoquercitrin (6) and rutin (7) exhibited strong inhibitory effects with IC(50) values of 1.22 +/- 0.01, 3.75 +/- 0.02 and 3.60 +/- 0.02, respectively. The MPO activity detected for the new derivative 1 was markedly decreased (IC(50) 10.3 +/- 0.03) when compared with known flavonols 5-7, and interestingly increased when tested against ABTS scavenging activity. (C) 2008 Published by Elsevier Ltd.en
dc.format.extent1739-1744-
dc.language.isoeng-
dc.publisherPergamon-Elsevier B.V. Ltd-
dc.sourceWeb of Science-
dc.subjectPterogyne nitensen
dc.subjectFabaceaeen
dc.subjectacylated flavonolen
dc.subjectmyeloperoxidaseen
dc.subjectantioxidanten
dc.titleFlavonols from Pterogyne nitens and their evaluation as myeloperoxidase inhibitorsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)-
dc.description.affiliationUniv Estadual Paulista, Inst Quim, Dept Bioquim & Tecnol Quim, BR-14801900 Araraquara, SP, Brazil-
dc.description.affiliationUNESP, Fac Ciencias Farmaceut, Dept Anal Clin, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationSecao Fisiol & Bioquim Plantas, Inst Bot, BR-01061970 São Paulo, SP, Brazil-
dc.description.affiliationUniv Fed Rio de Janeiro, LASSBIO, Fac Farm, BR-21944910 Rio de Janeiro, Brazil-
dc.description.affiliationUniv Estadual Paulista, Inst Quim, NuBBE Prod Nat, BR-14801970 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, Dept Bioquim & Tecnol Quim, BR-14801900 Araraquara, SP, Brazil-
dc.description.affiliationUnespUNESP, Fac Ciencias Farmaceut, Dept Anal Clin, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, NuBBE Prod Nat, BR-14801970 Araraquara, SP, Brazil-
dc.identifier.doi10.1016/j.phytochem.2008.01.006-
dc.identifier.wosWOS:000256782100013-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofPhytochemistry-
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