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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/252
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dc.contributor.authorIglesias, C. V.-
dc.contributor.authorAparicio, R.-
dc.contributor.authorRodrigues-Simioni, L.-
dc.contributor.authorCamargo, E. A.-
dc.contributor.authorAntunes, E.-
dc.contributor.authorMarangoni, S.-
dc.contributor.authorToyoma, D. D.-
dc.contributor.authorBeriam, LOS-
dc.contributor.authorMonteiro, HSA-
dc.contributor.authorToyama, M. H.-
dc.date.accessioned2014-05-20T13:12:16Z-
dc.date.accessioned2016-10-25T16:32:40Z-
dc.date.available2014-05-20T13:12:16Z-
dc.date.available2016-10-25T16:32:40Z-
dc.date.issued2005-12-01-
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2005.07.017-
dc.identifier.citationToxicon. Oxford: Pergamon-Elsevier B.V., v. 46, n. 7, p. 751-758, 2005.-
dc.identifier.issn0041-0101-
dc.identifier.urihttp://hdl.handle.net/11449/252-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/252-
dc.description.abstractFlavonoids are potent anti-inflammatory compounds isolated from several plant extracts, and have been used experimentally against inflammatory processes. In this work, a PLA(2) isolated from the Crotalus durissus cascavella venom and rat paw oedema were used as a model to. study the effect of flavonoids on PLA(2). We observed that a treatment of PLA(2) with morin induces several modifications in the aromatic amino acids, with accompanying changes in its amino acid composition. In addition, results from circular dichroism spectroscopy and UV scanning revealed important structural modifications. Concomitantly, a considerable decrease in the enzymatic and antibacterial activities was observed, even though anti-inflammatory and neurotoxic activities were not affected. These apparent controversial results may be an indication that PLA(2) possess a second pharmacological site which does not affect or depend on the enzymatic activity. (c) 2005 Elsevier Ltd. All rights reserved.en
dc.format.extent751-758-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectPLA(2)pt
dc.subjectcircular dichroism spectroscopypt
dc.subjectantibacterial activitypt
dc.subjectflavonoidspt
dc.subjectmorinpt
dc.subjectCrotalus durissus cascavellapt
dc.subjectneurotoxicpt
dc.titleEffects of morin on snake venom phospholipase A(2) (PLA(2))en
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionInst Biol-
dc.contributor.institutionInst Quim-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniv Presbiteriana Mackenzie-
dc.contributor.institutionUFC-
dc.contributor.institutionInst Biol Campinas-
dc.description.affiliationUniv Sao Vicente, CLP, UNESP, Sao Vicente, SP, Brazil-
dc.description.affiliationInst Biol, Dept Bioquim, Campinas, SP, Brazil-
dc.description.affiliationInst Quim, Campinas, SP, Brazil-
dc.description.affiliationUNICAMP, Fac Med, Dept Farmacol, Campinas, SP, Brazil-
dc.description.affiliationUniv Presbiteriana Mackenzie, Fac Ciências Biol Exatas & Expt, Campinas, SP, Brazil-
dc.description.affiliationUFC, Dept Farmacol, Fortaleza, Ceara, Brazil-
dc.description.affiliationInst Biol Campinas, Ctr Expt, Lab Bacteriol Vegetal, Campinas, SP, Brazil-
dc.description.affiliationUnespUniv Sao Vicente, CLP, UNESP, Sao Vicente, SP, Brazil-
dc.identifier.doi10.1016/j.toxicon.2005.07.017-
dc.identifier.wosWOS:000233491400005-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofToxicon-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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