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dc.contributor.authorRebuglio Vellosa, Jose Carlos-
dc.contributor.authorKhalil, Najeh Maissar-
dc.contributor.authorGutierres, Vainia Ortega-
dc.contributor.authorSantos, Vainia Aparecida de Freitas Formenton Macedo dos-
dc.contributor.authorFurlan, Maysa-
dc.contributor.authorBrunetti, Iguatemy Lourenço-
dc.contributor.authorOliveira, Olga Maria Mascarenhas de Faria-
dc.identifier.citationBrazilian Journal of Pharmaceutical Sciences. São Paulo: Univ São Paulo, Conjunto Quimicas, v. 45, n. 1, p. 99-107, 2009.-
dc.description.abstractReactive oxygen species (ROS) and free radical species have been implicated in initiating or accompanying many diseases in living organisms; there is thus, a continual need for antioxidants molecules to inactivate ROS/free radicals. Many studies of plants crude extracts have demonstrated free-radical scavenging and antioxidant action. Salacia species have long been used, in several countries, as traditional medicines against certain diseases and for their anti-inflammatory properties. In this Study, Salacia campestris Walp (Hippocrateaceae) root bark ethanol extract (ScEtOH) was assessed for its ability to scavenge free radicals and reactive oxygen species; the results were expressed as percentage inhibition of the active species. ScEtOH was efficient against studied species: DPPH radical (obtained inhibition = 30%), ABTS(center dot+) (IC(50) = 1.8 +/- 0.8 mu g/mL), HOCI (IC(50) = 1.7 +/- 0.1 mu g/mL), O2(center dot-) (obtained inhibition = 32%), and NO(center dot) (obtained inhibition = 18%). Peroxidase activity inhibition was evaluated through the guaiacol oxidation reaction catalyzed by hemin, HRP and. myeloperoxidase (MPO); data showed that ScEtOH at 10 mu g/mL led to 54 and 51% of inhibition, respectively, for the hemin and HRP systems. In the MPO system, ScEtOH promoted a 50% inhibition at 8.9 mu g/mL, whereas quercetin, a powerful MPO inhibitor, inhibited this system at 1.35 mu g/mL.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.publisherUniversidade de São Paulo (USP), Conjunto Quimicas-
dc.sourceWeb of Science-
dc.titleSalacia campestris root bark extract: peroxidase inhibition, antioxidant and antiradical profileen
dc.contributor.institutionUniversidade Estadual de Ponta Grossa (UEPG)-
dc.contributor.institutionUniversidade Estadual do Centro Oeste (UNICENTRO)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationParana State Univ Ponta Grossa, Univ Lab Clin Anal, Toxicol & Clin Anal Dept, Maringa, Parana, Brazil-
dc.description.affiliationMidWest Parana State Univ, Dept Pharm, Maringa, Parana, Brazil-
dc.description.affiliationUNESP, Dept Bioquim & Tecnol Quim, Inst Quim, BR-4800900 Araraquara, SP, Brazil-
dc.description.affiliationUNESP, Clin Anal Dept, Sch Pharmaceut Sci, BR-4800900 Araraquara, SP, Brazil-
dc.description.affiliationUNESP, Dept Organ Chem, Inst Chem, BR-4800900 Araraquara, SP, Brazil-
dc.description.affiliationUnespUNESP, Dept Bioquim & Tecnol Quim, Inst Quim, BR-4800900 Araraquara, SP, Brazil-
dc.description.affiliationUnespUNESP, Clin Anal Dept, Sch Pharmaceut Sci, BR-4800900 Araraquara, SP, Brazil-
dc.description.affiliationUnespUNESP, Dept Organ Chem, Inst Chem, BR-4800900 Araraquara, SP, Brazil-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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