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DC Field | Value | Language |
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dc.contributor.author | Rebuglio Vellosa, Jose Carlos | - |
dc.contributor.author | Khalil, Najeh Maissar | - |
dc.contributor.author | Gutierres, Vainia Ortega | - |
dc.contributor.author | Santos, Vainia Aparecida de Freitas Formenton Macedo dos | - |
dc.contributor.author | Furlan, Maysa | - |
dc.contributor.author | Brunetti, Iguatemy Lourenço | - |
dc.contributor.author | Oliveira, Olga Maria Mascarenhas de Faria | - |
dc.date.accessioned | 2014-05-20T14:17:42Z | - |
dc.date.accessioned | 2016-10-25T17:40:06Z | - |
dc.date.available | 2014-05-20T14:17:42Z | - |
dc.date.available | 2016-10-25T17:40:06Z | - |
dc.date.issued | 2009-01-01 | - |
dc.identifier | http://dx.doi.org/10.1590/S1984-82502009000100012 | - |
dc.identifier.citation | Brazilian Journal of Pharmaceutical Sciences. São Paulo: Univ São Paulo, Conjunto Quimicas, v. 45, n. 1, p. 99-107, 2009. | - |
dc.identifier.issn | 1984-8250 | - |
dc.identifier.uri | http://hdl.handle.net/11449/25305 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/25305 | - |
dc.description.abstract | Reactive oxygen species (ROS) and free radical species have been implicated in initiating or accompanying many diseases in living organisms; there is thus, a continual need for antioxidants molecules to inactivate ROS/free radicals. Many studies of plants crude extracts have demonstrated free-radical scavenging and antioxidant action. Salacia species have long been used, in several countries, as traditional medicines against certain diseases and for their anti-inflammatory properties. In this Study, Salacia campestris Walp (Hippocrateaceae) root bark ethanol extract (ScEtOH) was assessed for its ability to scavenge free radicals and reactive oxygen species; the results were expressed as percentage inhibition of the active species. ScEtOH was efficient against studied species: DPPH radical (obtained inhibition = 30%), ABTS(center dot+) (IC(50) = 1.8 +/- 0.8 mu g/mL), HOCI (IC(50) = 1.7 +/- 0.1 mu g/mL), O2(center dot-) (obtained inhibition = 32%), and NO(center dot) (obtained inhibition = 18%). Peroxidase activity inhibition was evaluated through the guaiacol oxidation reaction catalyzed by hemin, HRP and. myeloperoxidase (MPO); data showed that ScEtOH at 10 mu g/mL led to 54 and 51% of inhibition, respectively, for the hemin and HRP systems. In the MPO system, ScEtOH promoted a 50% inhibition at 8.9 mu g/mL, whereas quercetin, a powerful MPO inhibitor, inhibited this system at 1.35 mu g/mL. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
dc.format.extent | 99-107 | - |
dc.language.iso | eng | - |
dc.publisher | Universidade de São Paulo (USP), Conjunto Quimicas | - |
dc.source | Web of Science | - |
dc.title | Salacia campestris root bark extract: peroxidase inhibition, antioxidant and antiradical profile | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual de Ponta Grossa (UEPG) | - |
dc.contributor.institution | Universidade Estadual do Centro Oeste (UNICENTRO) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Parana State Univ Ponta Grossa, Univ Lab Clin Anal, Toxicol & Clin Anal Dept, Maringa, Parana, Brazil | - |
dc.description.affiliation | MidWest Parana State Univ, Dept Pharm, Maringa, Parana, Brazil | - |
dc.description.affiliation | UNESP, Dept Bioquim & Tecnol Quim, Inst Quim, BR-4800900 Araraquara, SP, Brazil | - |
dc.description.affiliation | UNESP, Clin Anal Dept, Sch Pharmaceut Sci, BR-4800900 Araraquara, SP, Brazil | - |
dc.description.affiliation | UNESP, Dept Organ Chem, Inst Chem, BR-4800900 Araraquara, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP, Dept Bioquim & Tecnol Quim, Inst Quim, BR-4800900 Araraquara, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP, Clin Anal Dept, Sch Pharmaceut Sci, BR-4800900 Araraquara, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP, Dept Organ Chem, Inst Chem, BR-4800900 Araraquara, SP, Brazil | - |
dc.identifier.doi | 10.1590/S1984-82502009000100012 | - |
dc.identifier.scielo | S1984-82502009000100012 | - |
dc.identifier.wos | WOS:000267750700012 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | WOS000267750700012.pdf | - |
dc.relation.ispartof | Brazilian Journal of Pharmaceutical Sciences | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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