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dc.contributor.authorFerraz, E. R. A.-
dc.contributor.authorUmbuzeiro, G. A.-
dc.contributor.authorde-Almeida, G.-
dc.contributor.authorCaloto-Oliveira, A.-
dc.contributor.authorChequer, F. M. D.-
dc.contributor.authorZanoni, Maria Valnice Boldrin-
dc.contributor.authorDorta, D. J.-
dc.contributor.authorOliveira, D. P.-
dc.date.accessioned2014-05-20T14:19:25Z-
dc.date.accessioned2016-10-25T17:41:04Z-
dc.date.available2014-05-20T14:19:25Z-
dc.date.available2016-10-25T17:41:04Z-
dc.date.issued2011-10-01-
dc.identifierhttp://dx.doi.org/10.1002/tox.20576-
dc.identifier.citationEnvironmental Toxicology. Malden: Wiley-blackwell, v. 26, n. 5, p. 489-497, 2011.-
dc.identifier.issn1520-4081-
dc.identifier.urihttp://hdl.handle.net/11449/25856-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/25856-
dc.description.abstractAzo dyes are of environmental concern due to their degradation products, widespread use, and low-removal rate during conventional treatment. Their toxic properties are related to the nature and position of the substituents with respect to the aromatic rings and amino nitrogen atom. The dyes Disperse Red 1 and Disperse Red 13 were tested for Salmonella mutagenicity, cell viability by annexin V, and propidium iodide in HepG2 and by aquatic toxicity assays using daphnids. Both dyes tested positive in the Salmonella assay, and the suggestion was made that these compounds induce mainly frame-shift mutations and that the enzymes nitroreductase and O-acetyltransferase play an important role in the observed effect. In addition, it was shown that the presence of the chlorine substituent in Disperse Red 13 decreased the mutagenicity about 14 times when compared with Disperse Red 1, which shows the same structure as Disperse Red 13, but without the chlorine substituent. The presence of this substituent did not cause cytotoxicity in HepG2 cells, but toxicity to the water flea Daphnia similis increased in the presence of the chlorine substituent. These data suggest that the insertion of a chlorine substituent could be an alternative in the design of dyes with low-mutagenic potency, although the ecotoxicity should be carefully evaluated. (C) 2010 Wiley Periodicals, Inc. Environ Toxicol 26: 489-497, 2011.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.format.extent489-497-
dc.language.isoeng-
dc.publisherWiley-Blackwell-
dc.sourceWeb of Science-
dc.subjectazo dyesen
dc.subjectDisperse Red 1en
dc.subjectDisperse Red 13en
dc.subjectchlorine substituenten
dc.subjectSalmonella mutagenicity assayen
dc.subjectDaphnia similisen
dc.titleDifferential Toxicity of Disperse Red 1 and Disperse Red 13 in the Ames Test, HepG2 Cytotoxicity Assay, and Daphnia Acute Toxicity Testen
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv São Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil-
dc.description.affiliationUniv Estadual Campinas, Fac Technol, BR-13484332 Limeira, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Quim Araraquara, Dept Quim Anal, BR-14800900 Araraquara, SP, Brazil-
dc.description.affiliationUniv São Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Quim Araraquara, Dept Quim Anal, BR-14800900 Araraquara, SP, Brazil-
dc.identifier.doi10.1002/tox.20576-
dc.identifier.wosWOS:000295035600007-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofEnvironmental Toxicology-
dc.identifier.orcid0000-0002-2296-1393-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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