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http://acervodigital.unesp.br/handle/11449/26057Registro de metadados completo
| Campo DC | Valor | Idioma |
|---|---|---|
| dc.contributor.author | Santos, Vania A. F. F. M. | - |
| dc.contributor.author | Regasini, Luis O. | - |
| dc.contributor.author | Nogueira, Claudio R. | - |
| dc.contributor.author | Passerini, Gabriela D. | - |
| dc.contributor.author | Martinez, Isabel | - |
| dc.contributor.author | Bolzani, Vanderlan da Silva | - |
| dc.contributor.author | Graminha, Márcia Aparecida Silva | - |
| dc.contributor.author | Cicarelli, Regina Maria Barreto | - |
| dc.contributor.author | Furlan, Maysa | - |
| dc.date.accessioned | 2014-05-20T14:20:10Z | - |
| dc.date.accessioned | 2016-10-25T17:41:28Z | - |
| dc.date.available | 2014-05-20T14:20:10Z | - |
| dc.date.available | 2016-10-25T17:41:28Z | - |
| dc.date.issued | 2012-05-01 | - |
| dc.identifier | http://dx.doi.org/10.1021/np300077r | - |
| dc.identifier.citation | Journal of Natural Products. Washington: Amer Chemical Soc, v. 75, n. 5, p. 991-995, 2012. | - |
| dc.identifier.issn | 0163-3864 | - |
| dc.identifier.uri | http://hdl.handle.net/11449/26057 | - |
| dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/26057 | - |
| dc.description.abstract | As part of a bioprospecting program aimed at the discovery of antiprotozoal agents from the Brazilian flora, two new sesquiterpene pyridine alkaloids, ilicifoliunines A (1) and B (2), along with the known alkaloids aquifoliunine E-I (3) and mayteine (4), were isolated from the root bark of Maytenus ilicifolia. The structures of 1 and 2 were established on the basis of spectroscopic data interpretation. Alkaloid 3 displayed potent in vitro antiprotozoal activity against Leishmania chagasi and Trypanosoma cruzi, with IC50 values of 1.4 and 41.9 mu M, respectively, as well as low cytotoxicity against murine peritoneal macrophages (IC50 of 1.8 mM). | en |
| dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
| dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
| dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
| dc.description.sponsorship | Pró-Reitoria de Pesquisa da UNESP (PROPe UNESP) | - |
| dc.format.extent | 991-995 | - |
| dc.language.iso | eng | - |
| dc.publisher | Amer Chemical Soc | - |
| dc.source | Web of Science | - |
| dc.title | Antiprotozoal Sesquiterpene Pyridine Alkaloids from Maytenus ilicifolia | en |
| dc.type | outro | - |
| dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
| dc.description.affiliation | Univ Estadual Paulista UNESP, Inst Quim, Dept Quim Organ, BR-14800900 Araraquara, SP, Brazil | - |
| dc.description.affiliation | Univ Estadual Paulista UNESP, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil | - |
| dc.description.affiliationUnesp | Univ Estadual Paulista UNESP, Inst Quim, Dept Quim Organ, BR-14800900 Araraquara, SP, Brazil | - |
| dc.description.affiliationUnesp | Univ Estadual Paulista UNESP, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil | - |
| dc.identifier.doi | 10.1021/np300077r | - |
| dc.identifier.wos | WOS:000304385800021 | - |
| dc.rights.accessRights | Acesso restrito | - |
| dc.relation.ispartof | Journal of Natural Products | - |
| Aparece nas coleções: | Artigos, TCCs, Teses e Dissertações da Unesp | |
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