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dc.contributor.authorSantos, Vania A. F. F. M.-
dc.contributor.authorRegasini, Luis O.-
dc.contributor.authorNogueira, Claudio R.-
dc.contributor.authorPasserini, Gabriela D.-
dc.contributor.authorMartinez, Isabel-
dc.contributor.authorBolzani, Vanderlan da Silva-
dc.contributor.authorGraminha, Márcia Aparecida Silva-
dc.contributor.authorCicarelli, Regina Maria Barreto-
dc.contributor.authorFurlan, Maysa-
dc.date.accessioned2014-05-20T14:20:10Z-
dc.date.accessioned2016-10-25T17:41:28Z-
dc.date.available2014-05-20T14:20:10Z-
dc.date.available2016-10-25T17:41:28Z-
dc.date.issued2012-05-01-
dc.identifierhttp://dx.doi.org/10.1021/np300077r-
dc.identifier.citationJournal of Natural Products. Washington: Amer Chemical Soc, v. 75, n. 5, p. 991-995, 2012.-
dc.identifier.issn0163-3864-
dc.identifier.urihttp://hdl.handle.net/11449/26057-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/26057-
dc.description.abstractAs part of a bioprospecting program aimed at the discovery of antiprotozoal agents from the Brazilian flora, two new sesquiterpene pyridine alkaloids, ilicifoliunines A (1) and B (2), along with the known alkaloids aquifoliunine E-I (3) and mayteine (4), were isolated from the root bark of Maytenus ilicifolia. The structures of 1 and 2 were established on the basis of spectroscopic data interpretation. Alkaloid 3 displayed potent in vitro antiprotozoal activity against Leishmania chagasi and Trypanosoma cruzi, with IC50 values of 1.4 and 41.9 mu M, respectively, as well as low cytotoxicity against murine peritoneal macrophages (IC50 of 1.8 mM).en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipPró-Reitoria de Pesquisa da UNESP (PROPe UNESP)-
dc.format.extent991-995-
dc.language.isoeng-
dc.publisherAmer Chemical Soc-
dc.sourceWeb of Science-
dc.titleAntiprotozoal Sesquiterpene Pyridine Alkaloids from Maytenus ilicifoliaen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Estadual Paulista UNESP, Inst Quim, Dept Quim Organ, BR-14800900 Araraquara, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista UNESP, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Inst Quim, Dept Quim Organ, BR-14800900 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.identifier.doi10.1021/np300077r-
dc.identifier.wosWOS:000304385800021-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Natural Products-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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