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http://acervodigital.unesp.br/handle/11449/26092Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Vieira-Junior, Gerardo M. | - |
| dc.contributor.author | Dutra, Luiz A. | - |
| dc.contributor.author | Ferreira, Paulo M. P. | - |
| dc.contributor.author | de Moraes, Manoel O. | - |
| dc.contributor.author | Lotufo, Leticia V. Costa | - |
| dc.contributor.author | Pessoa, Claudia do O. | - |
| dc.contributor.author | Torres, Roseli Buzanelli | - |
| dc.contributor.author | Boralle, Nivaldo | - |
| dc.contributor.author | Bolzani, Vanderlan da Silva | - |
| dc.contributor.author | Cavalheiro, Alberto José | - |
| dc.date.accessioned | 2014-05-20T14:20:16Z | - |
| dc.date.accessioned | 2016-10-25T17:41:32Z | - |
| dc.date.available | 2014-05-20T14:20:16Z | - |
| dc.date.available | 2016-10-25T17:41:32Z | - |
| dc.date.issued | 2011-04-01 | - |
| dc.identifier | http://dx.doi.org/10.1021/np100840w | - |
| dc.identifier.citation | Journal of Natural Products. Washington: Amer Chemical Soc, v. 74, n. 4, p. 776-781, 2011. | - |
| dc.identifier.issn | 0163-3864 | - |
| dc.identifier.uri | http://hdl.handle.net/11449/26092 | - |
| dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/26092 | - |
| dc.description.abstract | Four new clerodane diterpenes, casearupestrins A-D (1-4), were isolated from the leaves of Casearia rupestris. Compounds 1 and 4 were acetylated to yield 2,7-di-O-acetylcasearupestrin A (5) and 2,6-di-O-acetylcasearupestrin D (6), All compounds were evaluated for cytotoxicity against a small panel of human cancer cell lines. Caseartipestrin A (1) exhibited the most potent activity against MDA/MB-435 (human Melanoma) and SF-295 (human glioblastoma) cells, superior to that of the standard drug:doxorubicin. | en |
| dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
| dc.description.sponsorship | Biota Instituto Virtual da Biodiversidade | - |
| dc.format.extent | 776-781 | - |
| dc.language.iso | eng | - |
| dc.publisher | Amer Chemical Soc | - |
| dc.source | Web of Science | - |
| dc.title | Cytotoxic Clerodane Diterpenes from Casearia rupestris | en |
| dc.type | outro | - |
| dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
| dc.contributor.institution | Universidade Federal do Piauí (UFPI) | - |
| dc.contributor.institution | Universidade Federal do Ceará (UFC) | - |
| dc.contributor.institution | Instituto Agronômico (IAC) | - |
| dc.description.affiliation | São Paulo State Univ, UNESP, Inst Chem, Nucley Bioassay Biosynth & Ecophysiol Nat Prod Nu, BR-14801970 Araraquara, SP, Brazil | - |
| dc.description.affiliation | Univ Fed Piaui, UFPI, Dept Ciencias Saude, BR-64600000 Picos, PI, Brazil | - |
| dc.description.affiliation | Universidade Federal do Ceará (UFC), Dept Fisiol & Farmacol, Lab Oncol Expt LOE, BR-60430270 Fortaleza, Ceara, Brazil | - |
| dc.description.affiliation | Instituto Agronômico de Campinas, Nucleo Jardim Bot, Campinas, SP, Brazil | - |
| dc.description.affiliationUnesp | São Paulo State Univ, UNESP, Inst Chem, Nucley Bioassay Biosynth & Ecophysiol Nat Prod Nu, BR-14801970 Araraquara, SP, Brazil | - |
| dc.description.sponsorshipId | FAPESP: 03/02176-7 | - |
| dc.identifier.doi | 10.1021/np100840w | - |
| dc.identifier.wos | WOS:000289742300036 | - |
| dc.rights.accessRights | Acesso restrito | - |
| dc.relation.ispartof | Journal of Natural Products | - |
| Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp | |
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