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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/26194
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dc.contributor.authorFunari, Cristiano Soleo-
dc.contributor.authorGullo, Fernanda Patricia-
dc.contributor.authorNapolitano, Assunta-
dc.contributor.authorCarneiro, Renato Lajarim-
dc.contributor.authorMendes-Giannini, Maria José Soares-
dc.contributor.authorFusco-Almeida, Ana Marisa-
dc.contributor.authorPiacente, Sonia-
dc.contributor.authorPizza, Cosimo-
dc.contributor.authorSiqueira Silva, Dulce Helena-
dc.date.accessioned2014-05-20T14:20:39Z-
dc.date.accessioned2016-10-25T17:41:43Z-
dc.date.available2014-05-20T14:20:39Z-
dc.date.available2016-10-25T17:41:43Z-
dc.date.issued2012-12-01-
dc.identifierhttp://dx.doi.org/10.1016/j.foodchem.2012.06.077-
dc.identifier.citationFood Chemistry. Oxford: Elsevier B.V., v. 135, n. 3, p. 2086-2094, 2012.-
dc.identifier.issn0308-8146-
dc.identifier.urihttp://hdl.handle.net/11449/26194-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/26194-
dc.description.abstractThe Lippia genus is used in ethnobotany as food, beverages, seasoning and antiseptic remedies, among others. The chemical compositions of fifteen extracts of six Lippia species were investigated comparatively by HPLC-PDA. To avoid data replication of previous works on this genus, Lippia lupulina Cham. root ethanol extract was selected for isolation procedures based on Principal Component Analyses (PCA) of such data. Seven compounds previously unreported in this genus were isolated from this extract (a triterpene, two furanonaphtoquinones, a furanochromone, an isoflavone, a stilbene and an iridoid). The activities of extracts, fractions and pure compounds towards Candida albicans, Candida krusei, Candida parapsilosis and Cryptococcus neoformans were investigated. Two fractions from the extract of Lippia salviaefolia leaves showed marked inhibition of fungal growth, in addition to verbascoside and asebogenin, which showed MICs lower than 15.6 mu g/ml and may be promising leads for the development of new antifungal agents, especially against C. neoformans. (C) 2012 Elsevier Ltd. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent2086-2094-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectVerbenaceaeen
dc.subjectLippia sppen
dc.subjectDereplicationen
dc.subjectAntifungalen
dc.subjectCandida spp.en
dc.subjectCryptococcus neoformansen
dc.titleChemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazilen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)-
dc.contributor.institutionUniv Salerno-
dc.description.affiliationSão Paulo State Univ, Inst Chem, NuBBE, BR-14801970 Araraquara, SP, Brazil-
dc.description.affiliationSão Paulo State Univ, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Chem, BR-13565905 São Carlos, SP, Brazil-
dc.description.affiliationUniv Salerno, Dipartimento Sci Farmaceut, I-84084 Fisciano, SA, Italy-
dc.description.affiliationUnespSão Paulo State Univ, Inst Chem, NuBBE, BR-14801970 Araraquara, SP, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, Fac Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 04/07932-7-
dc.identifier.doi10.1016/j.foodchem.2012.06.077-
dc.identifier.wosWOS:000310396700165-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileWOS000310396700165.pdf-
dc.relation.ispartofFood Chemistry-
dc.identifier.orcid0000-0002-8059-0826-
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