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dc.contributor.authorMorandim-Giannetti, Andreia de A.-
dc.contributor.authorCotinguiba, Fernando-
dc.contributor.authorRegasini, Luis O.-
dc.contributor.authorFrigieri, Mariana C.-
dc.contributor.authorVaranda, Eliana Aparecida-
dc.contributor.authorCoqueiro, Aline-
dc.contributor.authorKato, Massuo J.-
dc.contributor.authorBolzani, Vanderlan da Silva-
dc.contributor.authorFurlan, Maysa-
dc.date.accessioned2014-05-20T14:20:48Z-
dc.date.accessioned2016-10-25T17:41:44Z-
dc.date.available2014-05-20T14:20:48Z-
dc.date.available2016-10-25T17:41:44Z-
dc.date.issued2011-06-15-
dc.identifierhttp://www.ajol.info/index.php/ajb/article/view/94310-
dc.identifier.citationAfrican Journal of Biotechnology. Victoria Island: Academic Journals, v. 10, n. 27, p. 5398-5401, 2011.-
dc.identifier.issn1684-5315-
dc.identifier.urihttp://hdl.handle.net/11449/26248-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/26248-
dc.description.abstractPhytochemical studies carried out with Piperaceae species have shown great diversity of secondary metabolites among which are several displayed considerable biological activities. The species Piper tuberculatum has been intensively investigated and a series of amides have been described. For instance, (E)-piplartine showed significant cytotoxic activity against tumor cell lines, especially human leukemia cell lines; antifungal activity against Cladosporium species; trypanocidal activity and others. Considering the popular use of P. tuberculatum and the lack of pharmacological studies regarding this plant species, the mutagenic and antimutagenic effect of (E)-piplartine was evaluated by the Ames test, using the strains TA97a, TA98, TA100 and TA102 of Salmonella typhimurium. No mutagenic activity was observed for this compound.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent5398-5401-
dc.language.isoeng-
dc.publisherAcademic Journals-
dc.sourceWeb of Science-
dc.subjectPiperaceaeen
dc.subjectPiper tuberculatumen
dc.subject(Z)-piplartineen
dc.subjectmutagenic activateden
dc.subjectAmes testen
dc.titleStudy of Salmonella typhimurium mutagenicity assay of (E)-piplartine by the Ames testen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionCtr Univ FEI-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationUniv Estadual São Paulo, Inst Quim, Dept Quim Organ, BR-14800900 Araraquara, SP, Brazil-
dc.description.affiliationCtr Univ FEI, Dept Engn Quim, BR-09850901 Sao Bernardo do Campo, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUniv São Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14801902 Araraquara, SP, Brazil-
dc.identifier.wosWOS:000294614400021-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileWOS000294614400021.pdf-
dc.relation.ispartofAfrican Journal of Biotechnology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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