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http://acervodigital.unesp.br/handle/11449/27216
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DC Field | Value | Language |
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dc.contributor.author | Cardoso, Rosilene Fressatti | - |
dc.contributor.author | Cardoso, Marco Antonio | - |
dc.contributor.author | Leite, Clarice Queico Fujimura | - |
dc.contributor.author | Sato, Daisy Nakamura | - |
dc.contributor.author | Mamizuka, Elsa Masae | - |
dc.contributor.author | Hirata, Rosário Dominguez Crespo | - |
dc.contributor.author | Mello, Fernando Fiúza de | - |
dc.contributor.author | Hirata, Mario Hiroyuki | - |
dc.date.accessioned | 2014-05-20T15:09:25Z | - |
dc.date.accessioned | 2016-10-25T17:43:53Z | - |
dc.date.available | 2014-05-20T15:09:25Z | - |
dc.date.available | 2016-10-25T17:43:53Z | - |
dc.date.issued | 2007-02-01 | - |
dc.identifier | http://dx.doi.org/10.1590/S0074-02762007000100009 | - |
dc.identifier.citation | Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 102, n. 1, p. 59-61, 2007. | - |
dc.identifier.issn | 0074-0276 | - |
dc.identifier.uri | http://hdl.handle.net/11449/27216 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/27216 | - |
dc.description.abstract | Resistance in Mycobacterium tuberculosis to isoniazid (INH) is caused by mutations in the catalase-peroxidase gene (katG) , and within the inhA promoter and/or in structural gene. A small percentage (~ 10%) of INH-resistant strains do not present mutations in both of these loci. Other genes have been associated with INH resistance including the gene encoding for NADH dehydrogenase (ndh) . Here we report the detection of two ndh locus mutations (CGT to TGT change in codon 13 and GTG to GCG change in codon 18) by analyzing 23 INH-resistant and in none of 13 susceptible isolates from Brazilian tuberculosis patients. We also detected two isolates without a mutation in ndh, or any of the other INH resistance-associated loci examined, suggesting the existence of additional, as yet to be described, INH resistance mechanisms. | en |
dc.format.extent | 59-61 | - |
dc.language.iso | eng | - |
dc.publisher | Instituto Oswaldo Cruz, Ministério da Saúde | - |
dc.source | SciELO | - |
dc.subject | Mycobacterium tuberculosis | en |
dc.subject | NADH dehydrogenase gene | en |
dc.subject | isoniazid resistance | en |
dc.title | Characterization of ndh gene of isoniazid resistant and susceptible Mycobacterium tuberculosis isolates from Brazil | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual de Maringá (UEM) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Instituto Adolfo Lutz (IAL) | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.contributor.institution | Instituto Clemente Ferreira | - |
dc.description.affiliation | Universidade Estadual de Maringá (UEM) Departamento de Análises Clínicas Laborartório de Bacteriologia Clínica | - |
dc.description.affiliation | Unesp Departamento de Ciências Biológicas | - |
dc.description.affiliation | Instituto Adolfo Lutz | - |
dc.description.affiliation | Universidade de São Paulo | - |
dc.description.affiliation | Instituto Clemente Ferreira | - |
dc.description.affiliationUnesp | Unesp Departamento de Ciências Biológicas | - |
dc.identifier.doi | 10.1590/S0074-02762007000100009 | - |
dc.identifier.scielo | S0074-02762007000100009 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | S0074-02762007000100009.pdf | - |
dc.relation.ispartof | Memórias do Instituto Oswaldo Cruz | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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