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dc.contributor.authorCardoso, Rosilene Fressatti-
dc.contributor.authorCardoso, Marco Antonio-
dc.contributor.authorLeite, Clarice Queico Fujimura-
dc.contributor.authorSato, Daisy Nakamura-
dc.contributor.authorMamizuka, Elsa Masae-
dc.contributor.authorHirata, Rosário Dominguez Crespo-
dc.contributor.authorMello, Fernando Fiúza de-
dc.contributor.authorHirata, Mario Hiroyuki-
dc.date.accessioned2014-05-20T15:09:25Z-
dc.date.accessioned2016-10-25T17:43:53Z-
dc.date.available2014-05-20T15:09:25Z-
dc.date.available2016-10-25T17:43:53Z-
dc.date.issued2007-02-01-
dc.identifierhttp://dx.doi.org/10.1590/S0074-02762007000100009-
dc.identifier.citationMemórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 102, n. 1, p. 59-61, 2007.-
dc.identifier.issn0074-0276-
dc.identifier.urihttp://hdl.handle.net/11449/27216-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/27216-
dc.description.abstractResistance in Mycobacterium tuberculosis to isoniazid (INH) is caused by mutations in the catalase-peroxidase gene (katG) , and within the inhA promoter and/or in structural gene. A small percentage (~ 10%) of INH-resistant strains do not present mutations in both of these loci. Other genes have been associated with INH resistance including the gene encoding for NADH dehydrogenase (ndh) . Here we report the detection of two ndh locus mutations (CGT to TGT change in codon 13 and GTG to GCG change in codon 18) by analyzing 23 INH-resistant and in none of 13 susceptible isolates from Brazilian tuberculosis patients. We also detected two isolates without a mutation in ndh, or any of the other INH resistance-associated loci examined, suggesting the existence of additional, as yet to be described, INH resistance mechanisms.en
dc.format.extent59-61-
dc.language.isoeng-
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde-
dc.sourceSciELO-
dc.subjectMycobacterium tuberculosisen
dc.subjectNADH dehydrogenase geneen
dc.subjectisoniazid resistanceen
dc.titleCharacterization of ndh gene of isoniazid resistant and susceptible Mycobacterium tuberculosis isolates from Brazilen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual de Maringá (UEM)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionInstituto Adolfo Lutz (IAL)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionInstituto Clemente Ferreira-
dc.description.affiliationUniversidade Estadual de Maringá (UEM) Departamento de Análises Clínicas Laborartório de Bacteriologia Clínica-
dc.description.affiliationUnesp Departamento de Ciências Biológicas-
dc.description.affiliationInstituto Adolfo Lutz-
dc.description.affiliationUniversidade de São Paulo-
dc.description.affiliationInstituto Clemente Ferreira-
dc.description.affiliationUnespUnesp Departamento de Ciências Biológicas-
dc.identifier.doi10.1590/S0074-02762007000100009-
dc.identifier.scieloS0074-02762007000100009-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileS0074-02762007000100009.pdf-
dc.relation.ispartofMemórias do Instituto Oswaldo Cruz-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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