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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/27220
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dc.contributor.authorDunder, Ricardo José-
dc.contributor.authorLuiz-Ferreira, Anderson-
dc.contributor.authorAlmeida, Ana Cristina Alves de-
dc.contributor.authorFaria, Felipe Meira de-
dc.contributor.authorTakayama, Christiane-
dc.contributor.authorSocca, Eduardo Augusto Rabelo-
dc.contributor.authorSalvador, Marcos José-
dc.contributor.authorMello, Gláucia Coelho-
dc.contributor.authorSantos, Catarina dos-
dc.contributor.authorOliva-Neto, Pedro de-
dc.contributor.authorSouza-Brito, Alba Regina Monteiro-
dc.date.accessioned2014-05-20T15:09:26Z-
dc.date.accessioned2016-10-25T17:43:53Z-
dc.date.available2014-05-20T15:09:26Z-
dc.date.available2016-10-25T17:43:53Z-
dc.date.issued2013-05-01-
dc.identifierhttp://dx.doi.org/10.1590/S0074-02762013000300002-
dc.identifier.citationMemórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 108, n. 3, p. 263-271, 2013.-
dc.identifier.issn0074-0276-
dc.identifier.urihttp://hdl.handle.net/11449/27220-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/27220-
dc.description.abstractThe present study evaluated the anti-inflammatory and analgesic properties of Agave sisalana Perrine in classic models of inflammation and pain. The hexanic fraction of A. sisalana (HFAS) was obtained by acid hydrolysis followed by hexanic reflux. Anti-inflammatory properties were examined in three acute mouse models (xylene ear oedema, hind paw oedema and pleurisy) and a chronic mouse model (granuloma cotton pellet). The antinociceptive potential was evaluated in chemical (acetic-acid) and thermal (tail-flick and hot-plate test) models of pain. When given orally, HFAS (5, 10, 25 and 50 mg/kg) reduced ear oedema (p < 0.0001; 52%, 71%, 62% and 42%, respectively). HFAS also reduced hind paw oedema at doses of 10 mg/kg and 25 mg/kg (p < 0.05; 42% and 58%, respectively) and pleurisy at doses of 10 mg/kg and 25 mg/kg (41% and 50%, respectively). In a chronic model, HFAS reduced inflammation by 46% and 58% at doses of 10 mg/kg and 25 mg/kg, respectively. Moreover, this fraction showed analgesic properties against the abdominal writhing in an acetic acid model (at doses of 5-25 mg/kg) with inhibitory rates of 24%, 54% and 48%. The HFAS also showed an increased latency time in the hot-plate (23% and 28%) and tail-flick tests (61% and 66%) for the 25 mg/kg and 50 mg/kg doses, respectively. These results suggest that HFAS has anti-inflammatory and analgesic properties.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.format.extent263-271-
dc.language.isoeng-
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde-
dc.sourceSciELO-
dc.subjectAgave sisalana Perrine ex Engelmen
dc.subjecthecogeninen
dc.subjecttigogeninen
dc.subjectanti-inflammatory activityen
dc.subjectanalgesic activityen
dc.titleApplications of the hexanic fraction of Agave sisalana Perrine ex Engelm (Asparagaceae): control of inflammation and pain screeningen
dc.typeoutro-
dc.contributor.institutionDepartamento de Biologia Estrutural e Funcional-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionInstituto de Biologia Departamento de Biologia Vegetal-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de Goiás (UFG)-
dc.description.affiliationDepartamento de Biologia Estrutural e Funcional-
dc.description.affiliationUniversidade Estadual de Campinas Faculdade de Ciências Médicas Departamento de Farmacologia-
dc.description.affiliationInstituto de Biologia Departamento de Biologia Vegetal-
dc.description.affiliationUniversidade Estadual Paulista Faculdade de Ciências e Letras de Assis Departamento de Biologia-
dc.description.affiliationUniversidade Federal de Goiás (UFG) Departamento de Ciências Biológicas-
dc.description.affiliationUnespUniversidade Estadual Paulista Faculdade de Ciências e Letras de Assis Departamento de Biologia-
dc.identifier.doi10.1590/S0074-02762013000300002-
dc.identifier.scieloS0074-02762013000300263-
dc.identifier.wosWOS:000320501000002-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofMemórias do Instituto Oswaldo Cruz-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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