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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/27604
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dc.contributor.authorMoraes, Carolina Morales-
dc.contributor.authorAbrami, Priscila-
dc.contributor.authorGonçalves, Marcos Moisés-
dc.contributor.authorAndréo Filho, Newton-
dc.contributor.authorFernandes, Sérgio Antonio-
dc.contributor.authorPaula, Eneida de-
dc.contributor.authorFraceto, Leonardo Fernandes-
dc.date.accessioned2014-05-20T15:10:23Z-
dc.date.accessioned2016-10-25T17:44:46Z-
dc.date.available2014-05-20T15:10:23Z-
dc.date.available2016-10-25T17:44:46Z-
dc.date.issued2007-08-01-
dc.identifierhttp://dx.doi.org/10.1590/S0100-40422007000400005-
dc.identifier.citationQuímica Nova. Sociedade Brasileira de Química, v. 30, n. 4, p. 777-784, 2007.-
dc.identifier.issn0100-4042-
dc.identifier.urihttp://hdl.handle.net/11449/27604-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/27604-
dc.description.abstractS(-) Bupivacaine (S(-)BVC) and Lidocaine (LDC) are widely used local anesthetics (LA). Hydroxypropyl beta-cyclodextrin (HP-beta-CD) is used as a drug-carrier system. The aim of this work was to characterize inclusion complexes between LA and HP-beta-CD. The affinity constants determined at different pHs show favourable complexation. The release kinetics experiments showed that S(-)BVC and LDC changed the released profiles in the presence of HP-beta-CD. Nuclear magnetic resonance experiments gave information about the interaction between LA and the cyclodextrin cavity. This study focused on the physicochemical characterization of drug-delivery formulations that come out as potentially new therapeutic options for pain treatment.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent777-784-
dc.language.isopor-
dc.publisherSociedade Brasileira de Química-
dc.sourceSciELO-
dc.subjectS(-) Bupivacaineen
dc.subjectlidocaineen
dc.subjectcyclodextrinen
dc.titlePreparação e caracterização físico-química de complexos de inclusão entre anestésicos locais e hidroxipropil-beta-ciclodextrinapt
dc.title.alternativePreperetion and physico-chemical characterization of inclusion complexes between local anesthetics and hydroxypropyl-b-cyclodextrinen
dc.typeoutro-
dc.contributor.institutionUniversidade de Sorocaba (UNISO)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniversidade de Sorocaba-
dc.description.affiliationUniversidade Estadual de Campinas Instituto de Biologia Departamento de Bioquímica-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho Departamento de Engenharia Ambiental-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho Departamento de Engenharia Ambiental-
dc.identifier.doi10.1590/S0100-40422007000400005-
dc.identifier.scieloS0100-40422007000400005-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileS0100-40422007000400005.pdf-
dc.relation.ispartofQuímica Nova-
dc.identifier.scopus2-s2.0-34548665052-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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