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DC Field | Value | Language |
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dc.contributor.author | Araujo, Daniele Ribeiro de | - |
dc.contributor.author | Paula, Eneida de | - |
dc.contributor.author | Fraceto, Leonardo Fernandes | - |
dc.date.accessioned | 2014-05-20T15:10:24Z | - |
dc.date.accessioned | 2016-10-25T17:44:47Z | - |
dc.date.available | 2014-05-20T15:10:24Z | - |
dc.date.available | 2016-10-25T17:44:47Z | - |
dc.date.issued | 2008-01-01 | - |
dc.identifier | http://dx.doi.org/10.1590/S0100-40422008000700032 | - |
dc.identifier.citation | Química Nova. Sociedade Brasileira de Química, v. 31, n. 7, p. 1775-1783, 2008. | - |
dc.identifier.issn | 0100-4042 | - |
dc.identifier.uri | http://hdl.handle.net/11449/27611 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/27611 | - |
dc.description.abstract | Many theories about the mechanism of action of local anesthetics (LA) are described in the literature. Two types of theories can be distinguished: those that focus on the direct effects of LA on their target protein in the axon membranes, i.e. the voltage-gated sodium channel and the ones that take into account the interaction of anesthetic molecules with the lipid membrane phase for the reversible nerve blockage. Since there is a direct correlation between LA hydrophobicity and potency, it is crucial to take this physico-chemical property into account to understand the mechanism of action of LA, be it on the sodium channel protein, lipid(s), or on the whole membrane phase. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.format.extent | 1775-1783 | - |
dc.language.iso | por | - |
dc.publisher | Sociedade Brasileira de Química | - |
dc.source | SciELO | - |
dc.subject | local anesthetic | en |
dc.subject | membrane | en |
dc.subject | voltage-gated sodium channel | en |
dc.title | Anestésicos locais: interação com membranas biológicas e com o canal de sódio voltagem-dependente | pt |
dc.title.alternative | Local anesthetics: interaction with biological membranes and with the voltage-gated sodium channel | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual de Campinas (UNICAMP) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Universidade Estadual de Campinas Instituto de Biologia Departamento de Bioquímica | - |
dc.description.affiliation | Universidade Estadual Paulista Júlio de Mesquita Filho Departamento de Engenharia Ambiental | - |
dc.description.affiliationUnesp | Universidade Estadual Paulista Júlio de Mesquita Filho Departamento de Engenharia Ambiental | - |
dc.identifier.doi | 10.1590/S0100-40422008000700032 | - |
dc.identifier.scielo | S0100-40422008000700032 | - |
dc.identifier.wos | WOS:000262432800032 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | S0100-40422008000700032.pdf | - |
dc.relation.ispartof | Química Nova | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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