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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/27614
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dc.contributor.authorMoraes, Carolina Morales-
dc.contributor.authorPaula, Eneida de-
dc.contributor.authorRosa, André Henrique-
dc.contributor.authorFraceto, Leonardo Fernandes-
dc.date.accessioned2014-05-20T15:10:24Z-
dc.date.accessioned2016-10-25T17:44:47Z-
dc.date.available2014-05-20T15:10:24Z-
dc.date.available2016-10-25T17:44:47Z-
dc.date.issued2008-01-01-
dc.identifierhttp://dx.doi.org/10.1590/S0100-40422008000800040-
dc.identifier.citationQuímica Nova. Sociedade Brasileira de Química, v. 31, n. 8, p. 2152-2155, 2008.-
dc.identifier.issn0100-4042-
dc.identifier.urihttp://hdl.handle.net/11449/27614-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/27614-
dc.description.abstractBupivacaine (S75-R25, NovaBupi®) is an amide type local anesthetic widely used. The present work consists of the development and validation of analytical methodology for evaluation of NovaBupi® content in the poly-lactide-co-glycolide nanospheres (PLGA-NS) by high performance liquid chromatography. The separation was made using the reversed-phase column LC-18, acetonitrile/phosphate buffer 85:15 v/v as mobile phase and detection at 220 nm. The results obtained show that the analytical methodology is accurate, reproducible, robust and linear over the concentration range 10-220.0 g/mL of NovaBupi®. The method was applied to determine the encapsulation efficiency and evaluate the release profile of NovaBupi®, showing good results.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent2152-2155-
dc.language.isopor-
dc.publisherSociedade Brasileira de Química-
dc.sourceSciELO-
dc.subjectbupivacaineen
dc.subjectPLGA nanospheresen
dc.subjectHPLCen
dc.titleValidação de metodologia analítica por cromatografia líquida de alta eficiência para quantificação de bupivacaína (S75-R25) em nanoesferas de poli(lactídeo-co-glicolídeo)pt
dc.title.alternativeValidation of analytical methodology by HPLC for quantification of bupivacaine (S75-R25) in poli-lactide-co-glicolide nanospheresen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniversidade Estadual de Campinas Departamento de Bioquímica-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho Departamento de Engenharia Ambiental-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho Departamento de Engenharia Ambiental-
dc.identifier.doi10.1590/S0100-40422008000800040-
dc.identifier.scieloS0100-40422008000800040-
dc.identifier.wosWOS:000262580000040-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileS0100-40422008000800040.pdf-
dc.relation.ispartofQuímica Nova-
dc.identifier.orcid0000-0002-2042-018Xpt
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