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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/3013
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dc.contributor.authorRoberto Monteiro, Gaby Ermelindo-
dc.contributor.authorBechara, Gervasio Henrique-
dc.contributor.authorFranzin, Alessandra Maria-
dc.contributor.authorFerreira de Miranda Santos, Isabel Kinney-
dc.date.accessioned2014-05-20T13:16:02Z-
dc.date.accessioned2016-10-25T16:37:28Z-
dc.date.available2014-05-20T13:16:02Z-
dc.date.available2016-10-25T16:37:28Z-
dc.date.issued2011-01-01-
dc.identifierhttp://dx.doi.org/10.1007/s10493-010-9380-x-
dc.identifier.citationExperimental and Applied Acarology. Dordrecht: Springer, v. 53, n. 1, p. 63-69, 2011.-
dc.identifier.issn0168-8162-
dc.identifier.urihttp://hdl.handle.net/11449/3013-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/3013-
dc.description.abstractResistance to tick feeding has been previously shown to be an acquired, immunologically mediated phenomenon in goats, associated with cutaneous basophilia to nymphs of Amblyomma cajennense, the Cayenne tick, after repeated infestations. on the other hand, it is well known that antigen-presenting cells (APCs) play an important role in the host immune reaction to tick infestations. The most able APCs for Th cells are the well defined dendritic cells, mononuclear phagocytes and B-lymphocytes. Immunohistochemical analysis of draining lymph nodes of goats repeatedly infested with nymphs of the ixodid tick A. cajennense to search for APCs was done. Pre-scapular lymph nodes draining the tick attachment sites were collected 15 days after both the first and third infestations. Tick infestations resulted in increased number of CD21(+) B lymphocytes in lymph nodes after the tertiary infestation. However, the number of CD11b(+) and CD11c(+) cells were not altered after the successive infestations. Lower numbers of CD11c(+) cells had infiltrated lymph nodes responsible for draining the tick infested skin. These findings suggest that acquired immunity of goats against nymphs of A. cajennense is possibly established by B lymphocytes during the first infestation and that APCs may play a key role in this mechanism.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipEuropean Commission-
dc.format.extent63-69-
dc.language.isoeng-
dc.publisherSpringer-
dc.sourceWeb of Science-
dc.subjectAmblyomma cajennenseen
dc.subjectNymphsen
dc.subjectGoatsen
dc.subjectImmunohistochemistryen
dc.subjectLymph nodesen
dc.subjectAPCsen
dc.titleAntigen-presenting cells in draining lymph nodes of goats repeatedly infested by the Cayenne tick Amblyomma cajennense nymphsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Eduardo Mondlane-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionBrazilian Enterprise Agr Res-
dc.description.affiliationSão Paulo State Univ UNESP, Fac Agron & Vet Sci, Dept Anim Pathol, BR-14884900 Jaboticabal, SP, Brazil-
dc.description.affiliationUniv Eduardo Mondlane, Fac Vet Med, Maputo, Mozambique-
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Ribeirao Preto, SP, Brazil-
dc.description.affiliationBrazilian Enterprise Agr Res, Natl Ctr Genet Resources & Biotechnol, Brasilia, DF, Brazil-
dc.description.affiliationUnespSão Paulo State Univ UNESP, Fac Agron & Vet Sci, Dept Anim Pathol, BR-14884900 Jaboticabal, SP, Brazil-
dc.description.sponsorshipIdEuropean Commission: 510561-
dc.identifier.doi10.1007/s10493-010-9380-x-
dc.identifier.wosWOS:000284651000007-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofExperimental and Applied Acarology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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