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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/30465
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dc.contributor.authorBaruffi, Marcelo Razera-
dc.contributor.authorEngel, Edgard Edward-
dc.contributor.authorSquire, Jeremy Andrew-
dc.contributor.authorTone, Luis Gonzaga-
dc.contributor.authorRogatto, Silvia Regina-
dc.date.accessioned2014-05-20T15:17:25Z-
dc.date.accessioned2016-10-25T17:51:18Z-
dc.date.available2014-05-20T15:17:25Z-
dc.date.available2016-10-25T17:51:18Z-
dc.date.issued2003-01-01-
dc.identifierhttp://dx.doi.org/10.1590/S1415-47572003000200001-
dc.identifier.citationGenetics and Molecular Biology. Sociedade Brasileira de Genética, v. 26, n. 2, p. 107-113, 2003.-
dc.identifier.issn1415-4757-
dc.identifier.urihttp://hdl.handle.net/11449/30465-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/30465-
dc.description.abstractWe applied a combination of comparative genomic hybridization (CGH) and fluorescence in situ hybridization (FISH), to characterize the genetic aberrations in three osteosarcomas (OS) and one Ewing's sarcoma. CGH identified recurrent chromosomal losses at 10p14-pter and gains at 8q22.3-24.1 in OS. Interphase FISH allowed to confirm 8q gain in two cases. A high amplification level of 11q12-qter was detected in one OS. The Ewing's sarcoma showed gain at 1p32-36.1 as the sole chromosome alteration. These studies demonstrate the value of molecular cytogenetic methods in the characterization of recurrent genomic alterations in bone tumor tissue.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent107-113-
dc.language.isoeng-
dc.publisherSociedade Brasileira de Genética-
dc.sourceSciELO-
dc.subjectcomparative genomic hybridizationen
dc.subjectCGHen
dc.subjectosteosarcomaen
dc.subjectEwing's Sarcomaen
dc.titleChromosomal imbalances detected in primary bone tumors by comparative genomic hybridization and interphase fluorescence in situ hybridizationen
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversity Health Network Princess Margaret Hospital Ontario Cancer Institute-
dc.contributor.institutionUniversity of Toronto Department of Medical Biophysics-
dc.contributor.institutionUniversity of Toronto Department of Laboratory Medicine and Pathobiology-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUSP Faculdade de Medicina Departamento de Puericultura e Pediatria-
dc.description.affiliationUSP Faculdade de Medicina Departamento de Biomecânica, Medicina e Reabilitação do Aparelho Locomotor-
dc.description.affiliationUniversity Health Network Princess Margaret Hospital Ontario Cancer Institute-
dc.description.affiliationUniversity of Toronto Department of Medical Biophysics-
dc.description.affiliationUniversity of Toronto Department of Laboratory Medicine and Pathobiology-
dc.description.affiliationUNESP Instituto de Biociências Departmento de Genética-
dc.description.affiliationUnespUNESP Instituto de Biociências Departmento de Genética-
dc.identifier.doi10.1590/S1415-47572003000200001-
dc.identifier.scieloS1415-47572003000200001-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileS1415-47572003000200001.pdf-
dc.relation.ispartofGenetics and Molecular Biology-
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