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http://acervodigital.unesp.br/handle/11449/32335
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DC Field | Value | Language |
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dc.contributor.author | Ferreiradovale, C. | - |
dc.contributor.author | Renzi, Antonio | - |
dc.contributor.author | Camargo, GPA | - |
dc.contributor.author | Saad, W. A. | - |
dc.contributor.author | Luiz, A. C. | - |
dc.contributor.author | Menani, José Vanderlei | - |
dc.contributor.author | Silveira, JEN | - |
dc.contributor.author | Camargo, LAA | - |
dc.date.accessioned | 2014-05-20T15:21:09Z | - |
dc.date.accessioned | 2016-10-25T17:54:30Z | - |
dc.date.available | 2014-05-20T15:21:09Z | - |
dc.date.available | 2016-10-25T17:54:30Z | - |
dc.date.issued | 1995-10-01 | - |
dc.identifier | http://www.scielo.br/scielo.php?script=sci_issues&pid=0100-879X&lng=en&nrm=iso | - |
dc.identifier.citation | Brazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 28, n. 10, p. 1097-1101, 1995. | - |
dc.identifier.issn | 0100-879X | - |
dc.identifier.uri | http://hdl.handle.net/11449/32335 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/32335 | - |
dc.description.abstract | We determined the effects of two classical angiotensin II (ANG II) antagonists, [Sar(1), Ala(8)]-ANG II and [Sar(1), Thr(8)]-ANG II, and losartan (a nonpeptide and selective antagonist for the AT 1 angiotensin receptors) on diuresis, natriuresis, kaliuresis and arterial blood pressure induced by ANG II administration into the median preoptic nucleus (MnPO) of male Holtzman rats weighing 250-300 g. Urine was collected in rats submitted to a water load (5% body weight) by gastric gavage, followed by a second water load (5% body weight) 1 h later. The volume of the drug solutions injected was 0.5 mu l over 10-15 s. Pre-treatment with [Sar(1), Ala(8)]-ANG II (12 rats) and [Sar(1), Thr(8)]-ANG II (9 rats), at the dose of 60 ng reduced (13.7 +/- 1.0 vs 11.0 +/- 1.0 and 10.7 +/- 1.2, respectively), whereas losartan (14 rats) at the dose of 160 ng totally blocked (13.7 +/- 1.0 vs 7.6 +/- 1.5) the urine excretion induced by injection of 12 ng of ANG II (14 rats). [Sar(1), Ala(8)]-ANG II impaired Na+ excretion (193 +/- 16 vs 120 +/- 19): whereas [Sar(1), Thr(8)]-ANG II and losartan blocked Na+ excretion (193 +/- 16 vs 77 +/- 15 and 100 +/- 12, respectively) induced by ANG II. Similar effects induced by ANG II on K+ excretion were observed with [Sar(1), Ala(8)]-ANG II, [Sar(1), Thr(8)]-ANG II, and losartan pretreatment (133 +/- 18 vs 108 +/- 11, 80 +/- 12, and 82 +/- 15, respectively). The same doses as above of [Sar(1), Ala(8)]-ANG II (8 rats), [Sar(1), Thr(8)]-ANG II (8 rats). and losartan (9 rats) blocked the increase in the arterial blood pressure induced by 12 ng of ANG II (12 rats) (32 +/- 4 ru 4 +/- 2, 3.5 +/- 1, and 2 +/- 1: respectively. The results indicate that the AT1 receptor subtype participates in the increases of diuresis, natriuresis. kaliuresis and arterial blood pressure induced by the administration of ANG II into the MnPO. | en |
dc.format.extent | 1097-1101 | - |
dc.language.iso | eng | - |
dc.publisher | Associação Brasileira de Divulgação Científica (ABRADIC) | - |
dc.source | Web of Science | - |
dc.subject | ANGIOTENSIN II | pt |
dc.subject | LOSARTAN | pt |
dc.subject | DIURESIS | pt |
dc.subject | NATRIURESIS | pt |
dc.subject | KALIURESIS | pt |
dc.subject | BLOOD PRESSURE | pt |
dc.subject | MNPO | pt |
dc.title | THE ROLE OF ANGIOTENSIN AT1 RECEPTORS IN THE DIURETIC, NATRIURETIC, KALIURETIC AND BLOOD-PRESSURE RESPONSES INDUCED BY ANGIOTENSIN-II ACTIVATION OF THE MEDIAN PREOPTIC NUCLEUS IN CONSCIOUS RATS | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | UNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL,BR-14801903 ARARAQUARA,SP,BRAZIL | - |
dc.description.affiliationUnesp | UNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL,BR-14801903 ARARAQUARA,SP,BRAZIL | - |
dc.identifier.wos | WOS:A1995TD30800011 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Brazilian Journal of Medical and Biological Research | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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