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http://acervodigital.unesp.br/handle/11449/32339
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DC Field | Value | Language |
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dc.contributor.author | Vicentini, A. P. | - |
dc.contributor.author | Gesztesi, J. L. | - |
dc.contributor.author | Franco, M. F. | - |
dc.contributor.author | Desouza, W. | - |
dc.contributor.author | Demoraes, J. Z. | - |
dc.contributor.author | Travassos, L. R. | - |
dc.contributor.author | Lopes, J. D. | - |
dc.date.accessioned | 2014-05-20T15:21:10Z | - |
dc.date.accessioned | 2016-10-25T17:54:30Z | - |
dc.date.available | 2014-05-20T15:21:10Z | - |
dc.date.available | 2016-10-25T17:54:30Z | - |
dc.date.issued | 1994-04-01 | - |
dc.identifier | http://iai.asm.org/content/62/4/1465 | - |
dc.identifier.citation | Infection and Immunity. Washington: Amer Soc Microbiology, v. 62, n. 4, p. 1465-1469, 1994. | - |
dc.identifier.issn | 0019-9567 | - |
dc.identifier.uri | http://hdl.handle.net/11449/32339 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/32339 | - |
dc.description.abstract | Extracellular matrix protein laminin binds specifically to yeast forms of Paracoccidioides brasiliensis and enhances adhesion of the fungus to the surface of epithelial Madin-Darby canine kidney cells in vitro. Immunoblotting of fungal extracts showed that the gp43 glycoprotein is responsible for adhesion. This was confirmed by binding assays using purified gp43, with a K-d of 3.7 nM. The coating of P. brasiliensis yeast forms with laminin before injection into hamster testicles enhanced the fungus virulence, resulting in a faster and more severe granulomatous disease. These results indicate that interaction of fungi with extracellular matrix elements may constitute a basis for the evolution of fungal infection toward regional spreading and dissemination. | en |
dc.format.extent | 1465-1469 | - |
dc.language.iso | eng | - |
dc.publisher | Amer Soc Microbiology | - |
dc.source | Web of Science | - |
dc.title | BINDING OF PARACOCCIDIOIDES-BRASILIENSIS TO LAMININ THROUGH SURFACE GLYCOPROTEIN GP43 LEADS TO ENHANCEMENT OF FUNGAL PATHOGENESIS | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Universidade Federal do Rio de Janeiro (UFRJ) | - |
dc.description.affiliation | ESCOLA PAULISTA MED,BR-04023062 SAO PAULO,BRAZIL | - |
dc.description.affiliation | UNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,FAC MED,DEPT PATOL,BR-18600 BOTUCATU,SP,BRAZIL | - |
dc.description.affiliation | UNIV FED RIO DE JANEIRO,INST BIOFIS CARLOS CHAGAS FILHO,BR-21941 RIO JANEIRO,BRAZIL | - |
dc.description.affiliationUnesp | UNIV ESTADUAL PAULISTA JULIO MESQUITA FILHO,FAC MED,DEPT PATOL,BR-18600 BOTUCATU,SP,BRAZIL | - |
dc.identifier.wos | WOS:A1994NC07400046 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.identifier.file | WOSA1994NC07400046.pdf | - |
dc.relation.ispartof | Infection and Immunity | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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