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http://acervodigital.unesp.br/handle/11449/32593
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DC Field | Value | Language |
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dc.contributor.author | Miyawaki, T. | - |
dc.contributor.author | Tsubokawa, H. | - |
dc.contributor.author | Yokota, H. | - |
dc.contributor.author | Oguro, K. | - |
dc.contributor.author | Konno, K. | - |
dc.contributor.author | Masuzawa, T. | - |
dc.contributor.author | Kawai, N. | - |
dc.date.accessioned | 2014-05-20T15:21:27Z | - |
dc.date.accessioned | 2016-10-25T17:54:52Z | - |
dc.date.available | 2014-05-20T15:21:27Z | - |
dc.date.available | 2016-10-25T17:54:52Z | - |
dc.date.issued | 2002-08-02 | - |
dc.identifier | http://dx.doi.org/10.1016/S0304-3940(02)00432-9 | - |
dc.identifier.citation | Neuroscience Letters. Clare: Elsevier Sci Ireland Ltd, v. 328, n. 1, p. 25-28, 2002. | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | http://hdl.handle.net/11449/32593 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/32593 | - |
dc.description.abstract | We studied the effects of a wasp toxin beta-pompilidotoxin (beta-PMTX) on rat hippocampal CA1 interneurons by the current-clamp technique. The firing patterns of pyramidal neurons and pyramidale interneurons were not affected by beta-PMTX, but in oriens and radiatum interneurons, beta-PMTX converted the action potentials to prolonged depolarizing potentials by slowing the inactivation of Na+ channels. In lacunosum moleculare interneurons, beta-PMTX induced initial bursting spikes followed by block of succeeding spikes. Comparison of beta-PMTX with a sea anemone toxin, ATX 11, revealed that ATX 11 altered the firing properties of pyramidal neurons and pyramidale interneurons that were unchanged by beta-PMTX. Our results suggest that beta-PMTX modulates Na+ currents in CAl interneurons differently in various CAl neurons and the toxin is useful to classify Na+ channel subtypes. (C) 2002 Elsevier B.V. Ireland Ltd. All rights reserved. | en |
dc.format.extent | 25-28 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.subject | interneuron | pt |
dc.subject | sodium channel | pt |
dc.subject | inactivation | pt |
dc.subject | wasp toxin | pt |
dc.subject | pompilidotoxin | pt |
dc.subject | sea anemone toxin | pt |
dc.title | Differential effects of novel wasp toxin on rat hippocampal interneurons | en |
dc.type | outro | - |
dc.contributor.institution | Jichi Med Sch | - |
dc.contributor.institution | Natl Inst Physiol Sci | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Jichi Med Sch, Dept Neurol Surg, Minami Kawachi, Tochigi 3290498, Japan | - |
dc.description.affiliation | Natl Inst Physiol Sci, Ctr Brain Expt, Okazaki, Aichi 4448585, Japan | - |
dc.description.affiliation | São Paulo State Univ, Inst Biosci Rio Claro, São Paulo, Brazil | - |
dc.description.affiliation | Jichi Med Sch, Dept Physiol, Minami Kawachi, Tochigi 3290498, Japan | - |
dc.description.affiliationUnesp | São Paulo State Univ, Inst Biosci Rio Claro, São Paulo, Brazil | - |
dc.identifier.doi | 10.1016/S0304-3940(02)00432-9 | - |
dc.identifier.wos | WOS:000177444700007 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Neuroscience Letters | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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