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http://acervodigital.unesp.br/handle/11449/327Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Torres, Maria Conceicao M. | - |
| dc.contributor.author | Pinto, Francisco das Chagas L. | - |
| dc.contributor.author | Braz-Filho, Raimundo | - |
| dc.contributor.author | Silveira, Edilberto R. | - |
| dc.contributor.author | Pessoa, Otilia Deusdenia L. | - |
| dc.contributor.author | Jorge, Roberta Jeane Bezerra | - |
| dc.contributor.author | Ximenes, Rafael Matos | - |
| dc.contributor.author | Azul Monteiro, Helena Serra | - |
| dc.contributor.author | Azul Monteiro Evangelista, Janaina Serra | - |
| dc.contributor.author | Diz-Filho, Eduardo B. S. | - |
| dc.contributor.author | Toyama, Marcos Hikari | - |
| dc.date.accessioned | 2014-05-20T13:12:21Z | - |
| dc.date.accessioned | 2016-10-25T16:32:48Z | - |
| dc.date.available | 2014-05-20T13:12:21Z | - |
| dc.date.available | 2016-10-25T16:32:48Z | - |
| dc.date.issued | 2011-10-01 | - |
| dc.identifier | http://dx.doi.org/10.1021/np200479a | - |
| dc.identifier.citation | Journal of Natural Products. Washington: Amer Chemical Soc, v. 74, n. 10, p. 2168-2173, 2011. | - |
| dc.identifier.issn | 0163-3864 | - |
| dc.identifier.uri | http://hdl.handle.net/11449/327 | - |
| dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/327 | - |
| dc.description.abstract | Three new solanidane alkaloids bearing a 22,23-epoxy ring (1-3) and four known compounds were isolated from leaves of Solanum campaniforme. The structures were determined using spectroscopic techniques, including ID and 2D NMR, and HRESIMS experiments. The antiophidic activity of the alkaloids was tested against Bothrops pauloensis venom. Compounds 1-3 completely inhibited myotoxicity without inhibiting phospholipase A(2) activity of the venom, while hemorrhage and skin necrosis were significantly reduced in the presence of alkaloids 1 and 2. | en |
| dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
| dc.description.sponsorship | Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico (FUNCAP) | - |
| dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
| dc.description.sponsorship | Programa de Apoio aos Núcleos de Excelência (PRONEX) | - |
| dc.format.extent | 2168-2173 | - |
| dc.language.iso | eng | - |
| dc.publisher | Amer Chemical Soc | - |
| dc.source | Web of Science | - |
| dc.title | Antiophidic Solanidane Steroidal Alkaloids from Solanum campaniforme | en |
| dc.type | outro | - |
| dc.contributor.institution | Universidade Federal do Ceará (UFC) | - |
| dc.contributor.institution | Univ Estadual Ceara | - |
| dc.contributor.institution | Universidade Estadual de Campinas (UNICAMP) | - |
| dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
| dc.description.affiliation | Universidade Federal do Ceará (UFC), Dept Quim Organ & Inorgan, BR-60021970 Fortaleza, Ceara, Brazil | - |
| dc.description.affiliation | Universidade Federal do Ceará (UFC), Dept Fisiol & Farmacol, BR-60430270 Fortaleza, Ceara, Brazil | - |
| dc.description.affiliation | Univ Estadual Ceara, Fac Vet, BR-60740000 Fortaleza, Ceara, Brazil | - |
| dc.description.affiliation | Univ Estadual Campinas, Dept Bioquim, Inst Biol, BR-13083970 Campinas, SP, Brazil | - |
| dc.description.affiliation | Univ Estadual Paulista, BR-11330900 Sao Vicente, SP, Brazil | - |
| dc.description.affiliationUnesp | Univ Estadual Paulista, BR-11330900 Sao Vicente, SP, Brazil | - |
| dc.identifier.doi | 10.1021/np200479a | - |
| dc.identifier.wos | WOS:000296206500019 | - |
| dc.rights.accessRights | Acesso restrito | - |
| dc.relation.ispartof | Journal of Natural Products | - |
| Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp | |
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