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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/32943
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dc.contributor.authorPaula, FJA-
dc.contributor.authorDICKDEPAULA, I-
dc.contributor.authorPontes, Anaglória-
dc.contributor.authorSchmitt, FCL-
dc.contributor.authorMendonca, B. B.-
dc.contributor.authorFoss, M. C.-
dc.date.accessioned2014-05-20T15:21:51Z-
dc.date.accessioned2016-10-25T17:55:24Z-
dc.date.available2014-05-20T15:21:51Z-
dc.date.available2016-10-25T17:55:24Z-
dc.date.issued1994-05-01-
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_issues&pid=0100-879X&lng=en&nrm=iso-
dc.identifier.citationBrazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 27, n. 5, p. 1149-1158, 1994.-
dc.identifier.issn0100-879X-
dc.identifier.urihttp://hdl.handle.net/11449/32943-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/32943-
dc.description.abstract1. Adrenal ectopic tissue has been detected in the paragonadal region of normal women. In patients with congenital adrenal hyperplasia due to 21-hydroxylase (21-OH) deficiency, the manifestation of hyperplasia of paragonadal accessory adrenal tissue has been usually reported to occur in males. Probably, this is the first report of a female with 3beta-hydroxysteroid dehydrogenase (3beta-HSD) deficiency with ectopic adrenal tissue in ovaries. However, the occurrence of hyperplasia of adrenal rests among women with classical congenital adrenal hyperplasia may not be rare, especially among patients with a late diagnosis.2. We report a woman with 3beta-HSD deficiency whose definitive diagnosis was made late at 41 years of age immediately before surgery for the removal of a uterine myoma. During surgery, exploration of the abdominal cavity revealed the presence of bilateral accessory adrenal tissue in the ovaries and in the para-aortic region. The patient had extremely high levels of ACTH (137 pmol/l), DHEA (901.0 nmol/l), DHEA-S (55.9 mumol/l), androstenedione (70.2 nmol/l), testosterone (23.0 nmol/l) and 17alpha-hydroxypregnenolone (234.4 nmol/l) suggesting 3beta-HSD deficiency.3. In view of these elevated androgen levels, with an absolute predominance of DHEA and DHEA-S, we evaluated the effect of this hormonal profile on carbohydrate tolerance and insulin response to glucose ingestion.4. The patient presented normal glucose tolerance but her insulin response was lower than that of 14 normal women (area under the curve, 3beta-HSD = 17,680 vs 50,034 pmol/l for the control group over a period of 3 h after glucose ingestion).5. These results support recent data suggesting that patients with increased serum DHEA and DHEA-S levels do not present resistance to insulin.en
dc.format.extent1149-1158-
dc.language.isoeng-
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)-
dc.sourceWeb of Science-
dc.subjectCONGENITAL ADRENAL HYPERPLASIApt
dc.subject3-BETA-HYDROXYSTEROID DEHYDROGENASE DEFICIENCYpt
dc.subjectINSULIN SENSITIVITYpt
dc.titleHYPERANDROGENISM DUE TO 3-BETA-HYDROXYSTEROID DEHYDROGENASE-DEFICIENCY WITH ACCESSORY ADRENOCORTICAL TISSUE - A HORMONAL AND METABOLIC EVALUATIONen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUNIV ESTADUAL PAULISTA,FAC MED BOTUCATU,DEPT CLIN MED,BR-18610000 BOTUCATU,SP,BRAZIL-
dc.description.affiliationUNIV ESTADUAL PAULISTA,FAC MED BOTUCATU,DEPT GINECOL & OBSTET,BR-18610000 BOTUCATU,SP,BRAZIL-
dc.description.affiliationUNIV ESTADUAL PAULISTA,FAC MED,DEPT CLIN MED,BR-05403900 SAO PAULO,SP,BRAZIL-
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA,FAC MED BOTUCATU,DEPT CLIN MED,BR-18610000 BOTUCATU,SP,BRAZIL-
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA,FAC MED BOTUCATU,DEPT GINECOL & OBSTET,BR-18610000 BOTUCATU,SP,BRAZIL-
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA,FAC MED,DEPT CLIN MED,BR-05403900 SAO PAULO,SP,BRAZIL-
dc.identifier.wosWOS:A1994NN03700008-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofBrazilian Journal of Medical and Biological Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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