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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/33748
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dc.contributor.authorViegas, C.-
dc.contributor.authorBolzani, Vanderlan da Silva-
dc.contributor.authorPimentel, LSB-
dc.contributor.authorCastro, N. G.-
dc.contributor.authorCabral, R. F.-
dc.contributor.authorCosta, R. S.-
dc.contributor.authorFloyd, C.-
dc.contributor.authorRocha, M. S.-
dc.contributor.authorYoung, MCM-
dc.contributor.authorBarreiro, E. J.-
dc.contributor.authorFraga, CAM-
dc.date.accessioned2014-05-20T15:22:50Z-
dc.date.accessioned2016-10-25T17:56:38Z-
dc.date.available2014-05-20T15:22:50Z-
dc.date.available2016-10-25T17:56:38Z-
dc.date.issued2005-07-01-
dc.identifierhttp://dx.doi.org/10.1016/j.bmc.2005.04.030-
dc.identifier.citationBioorganic & Medicinal Chemistry. Oxford: Pergamon-Elsevier B.V., v. 13, n. 13, p. 4184-4190, 2005.-
dc.identifier.issn0968-0896-
dc.identifier.urihttp://hdl.handle.net/11449/33748-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/33748-
dc.description.abstractFive new piperidine alkaloids were designed from natural (-)-3-O-acetyl-spectaline and (-)-spectaline that were obtained from the flowers of Senna spectabilis (sin. Cassia spectabilis, Leguminosae). Two semi-synthetic analogues (7 and 9) inhibited rat brain acetylcholinesterase, showing IC50 of 7.32 and 15.1 mu M, and were 21 and 9.5 times less potent against rat brain butyrylcholinesterase, respectively. Compound 9 (1 mg/kg, ip) was fully efficacious in reverting scopolamine-induced amnesia in mice. The two active compounds (7 and 9) did not show overt toxic effects at the doses tested in vivo. (c) 2005 Elsevier Ltd. All rights reserved.en
dc.format.extent4184-4190-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectpiperidine alkaloidspt
dc.subjectacetylcholinesterase inhibitorspt
dc.subjectAlzheimer's diseasept
dc.subjectSenna spectabilispt
dc.titleNew selective acetylcholinesterase inhibitors designed from natural piperidine alkaloidsen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionInst Bot-
dc.description.affiliationUniv Fed Rio de Janeiro, Fac Farm, Lab Avaliacao & Sintese Substancias Bioativas, BR-21944910 Rio de Janeiro, Brazil-
dc.description.affiliationUniv Estadual Paulista, Inst Quim, NuBBE, BR-14801970 Araraquara, Brazil-
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Ciências Biomed, Ctr Ciências Saude, Dept FArmacol Basica & Clin, Rio de Janeiro, Brazil-
dc.description.affiliationInst Bot, Secao Bioquim & Fisiol Plantas, São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, NuBBE, BR-14801970 Araraquara, Brazil-
dc.identifier.doi10.1016/j.bmc.2005.04.030-
dc.identifier.wosWOS:000229811900006-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofBioorganic & Medicinal Chemistry-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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