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http://acervodigital.unesp.br/handle/11449/33778
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DC Field | Value | Language |
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dc.contributor.author | Gomes, A. J. | - |
dc.contributor.author | Faustino, A. S. | - |
dc.contributor.author | Lunardi, C. N. | - |
dc.contributor.author | Lunardi, L. O. | - |
dc.contributor.author | Machado, A. E. H. | - |
dc.date.accessioned | 2014-05-20T15:22:52Z | - |
dc.date.accessioned | 2016-10-25T17:56:40Z | - |
dc.date.available | 2014-05-20T15:22:52Z | - |
dc.date.available | 2016-10-25T17:56:40Z | - |
dc.date.issued | 2007-03-06 | - |
dc.identifier | http://dx.doi.org/10.1016/j.ijpharm.2006.09.035 | - |
dc.identifier.citation | International Journal of Pharmaceutics. Amsterdam: Elsevier B.V., v. 332, n. 1-2, p. 153-160, 2007. | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.uri | http://hdl.handle.net/11449/33778 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/33778 | - |
dc.description.abstract | Psoralens are widely used for the treatment of hyperproliferative skin disease. In this work, we prepared nanoparticles (NP) containing a benzopsoralen (3-ethoxy carbonyl-2H-benzofuro[3,2-f]-1-benzopiran-2-one) by the solvent evaporation technique. We evaluated important NP parameters such as particle size, drug encapsulation efficiency, effect of the encapsulation process over the drug's photochemistry, zeta potential, external morphology, and in vitro release behavior. We also investigated the nanoparticle as a drug delivery system (DDS), as well as its target delivery to the action site, which is a very important parameter to increase the therapeutic use of psoralens and to reduce their side effects. The uptake of benzopsoralen-loaded PLGA nanoparticles by different kinds of cells found in rat peritoneal exudates was also studied. The photodamage promoted by irradiation with UV light revealed morphological characteristics of cell damage such as cytoplasmic vesiculation, mitochondrial damage, and swelling of both the granular endoplasmatic reticulum and nuclear membrane. This encapsulation method maintained the drug's properties and improved drug delivery to the target cell. (c) 2006 Elsevier B.V. All rights reserved. | en |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) | - |
dc.format.extent | 153-160 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.subject | Benzopsoralen | pt |
dc.subject | Exudates peritoneal cell | pt |
dc.subject | Nanoparticle | pt |
dc.subject | PUVA | pt |
dc.title | Evaluation of nanoparticles loaded with benzopsoralen in rat peritoneal exudate cells | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Federal de Uberlândia (UFU) | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Universidade Federal de Uberlândia (UFU), Inst Quim, Lab Fotoquim, BR-38400089 Uberlandia, MG, Brazil | - |
dc.description.affiliation | USP, Fac Ciências Farmaceut Ribeirao Preto, Farmacol Lab, BR-14040903 Ribeirao Preto, Brazil | - |
dc.description.affiliation | Univ Estadual Julio Mesquita Filho, Inst Biociencia, BR-13506900 Rio Claro, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Julio Mesquita Filho, Inst Biociencia, BR-13506900 Rio Claro, SP, Brazil | - |
dc.description.sponsorshipId | CNPq: 303911/2003-4 | - |
dc.description.sponsorshipId | CNPq: 302679/2002-2 | - |
dc.description.sponsorshipId | FAPEMIG: CEX 85/02 | - |
dc.identifier.doi | 10.1016/j.ijpharm.2006.09.035 | - |
dc.identifier.wos | WOS:000244806500019 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | International Journal of Pharmaceutics | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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