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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/34585
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dc.contributor.authorDeAngelis, P. R.-
dc.contributor.authorAntunes, V. R.-
dc.contributor.authorCamargo, GMPA-
dc.contributor.authorSaad, W. A.-
dc.contributor.authorRenzi, Antonio-
dc.contributor.authorCamargo, LLA-
dc.date.accessioned2014-05-20T15:23:54Z-
dc.date.accessioned2016-10-25T17:57:56Z-
dc.date.available2014-05-20T15:23:54Z-
dc.date.available2016-10-25T17:57:56Z-
dc.date.issued1996-12-01-
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_issues&pid=0100-879X&lng=en&nrm=iso-
dc.identifier.citationBrazilian Journal of Medical and Biological Research. São Paulo: Associação Bras Divulg Cientifica, v. 29, n. 12, p. 1671-1674, 1996.-
dc.identifier.issn0100-879X-
dc.identifier.urihttp://hdl.handle.net/11449/34585-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/34585-
dc.description.abstractWe investigated the effects of estrogen on sodium intake and excretion induced by angiotensin II (ANG II), atrial natriuretic peptide (ANP) or ANG II plus ANP injected into the median preoptic nucleus (MnPO). Female Holtzman rats weighing 250-300 g were used. Sodium ingestion and excretion 120 min after the injection of 0.5 mu l of 0.15 M NaCl into the MnPO were 0.3 +/- 0.1 ml (N = 12) and 29 +/- 7 mu Eq in intact rats, 0.5 +/- 0.2 ml (N = 10) and 27 +/- 6 mu Eq in ovariectomized rats, and 0.2 +/- 0.08 (N = 11) and 38 +/- 8 mu Eq in estrogen-treated ovariectomized (50 mu g/day for 21 days) rats, respectively. ANG II (21 mu M) injection in intact, ovariectomized, and estrogen-treated ovariectomized rats increased sodium intake (3.8 +/- 0.4, 1.8 +/- 0.3 and 1.2 +/- 0.2 ml/120 min, respectively) (N = 11) and increased sodium excretion (166 +/- 18, 82 +/- 22 and 86 +/- 12 mu Eq/120 min, respectively) (N = 11). ANP (65 mu M) injection in intact (N = 11), ovariectomized(N = 10)and estrogen-treated ovariectomized (N = 10) rats increased sodium intake (1.4 +/- 0.2, 1.8 +/- 0.3, and 1.7 +/- 0.3 ml/120 min, respectively) and sodium excretion (178 +/- 19, 187 +/- 9, and 232 +/- 29 mu Eq/120 min, respectively). Concomitant injection of ANG II and ANP into the MnPO of intact (N = 12), ovariectomized (N = 10) and estrogentreated ovariectomized (N = 10) rats caused smaller effects than those produced by each peptide given alone: 1.3 +/- 0.2, 0.9 +/- 0.2 and 0.3 +/- 0.1 ml/120 min for sodium intake, respectively, and 86 +/- 9, 58 +/- 7, and 22 +/- 4 mu Eq/120 min for sodium excretion, respectively. Taken together, these results demonstrate that there is an antagonistic interaction of ANP and ANG II on sodium intake and excretion, and that reproductive hormones affect this interaction.en
dc.format.extent1671-1674-
dc.language.isoeng-
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)-
dc.sourceWeb of Science-
dc.subjectatrial natriuretic peptidept
dc.subjectangiotensin IIpt
dc.subjectovariectomypt
dc.subjectsodium intakept
dc.subjectsodium excretionpt
dc.titleCentral interaction between atrial natriuretic peptide and angiotensin II in the control of sodium intake and excretion in female ratsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL,BR-14801903 ARARAQUARA,SP,BRAZIL-
dc.description.affiliationUnespUNIV ESTADUAL PAULISTA,FAC ODONTOL,DEPT CIENCIAS FISIOL,BR-14801903 ARARAQUARA,SP,BRAZIL-
dc.identifier.wosWOS:A1996VX80700016-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofBrazilian Journal of Medical and Biological Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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