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dc.contributor.authorCastro, AVB-
dc.contributor.authorMendonca, B. B.-
dc.contributor.authorBloise, W.-
dc.contributor.authorShuhama, T.-
dc.contributor.authorBrandao-Neto, J.-
dc.identifier.citationBiometals. Dordrecht: Kluwer Academic Publ, v. 12, n. 4, p. 347-352, 1999.-
dc.description.abstractPrevious in vitro studies have demonstrated zinc (Zn++) inhibition of basal and of potassium (K+) or thyrotropin-releasing hormone (TRH)-stimulated prolactin (PRL) secretion, in a selective, reversible, and dose-dependent manner. Thus, Zn++ may regulate physiologically pituitary PRL secretion. Furthermore, studies with patients with uremia, cirrhosis or prolactinoma, have shown the coexistence of hypozincemia and hyperprolactinemia and zinc supplementation did not correct hyperprolactinemia in these patients. In normal individuals Zn++ administration produced controversial results on PRL secretion. Here, we investigated whether zinc administration affects TRH-stimulated PRL in healthy men. We found that Zn++ administration does not change the TRH-stimulated PRL. Therefore, in normal conditions, Zn++ does not inhibit TRH-stimulated prolactinemia. In addition, we found that acute increases of blood PRL and TRH do not alter blood Zn++ levels.en
dc.publisherKluwer Academic Publ-
dc.sourceWeb of Science-
dc.subjectzinc tolerance testpt
dc.subjectthyrotropin tolerance testpt
dc.subjectprolactin secretionpt
dc.subjecthealthy menpt
dc.titleEffect of zinc administration on thyrotropin releasing hormone-stimulated prolactinemia in healthy menen
dc.contributor.institutionUniversidade de Brasília (UnB)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUnB, Fac Ciências Saude, Unidade Endocrinol & Metab, Brasilia, DF, Brazil-
dc.description.affiliationUSP, Fac Ciências Farmaceut, Lab Quim Analit, Ribeirao Preto, SP, Brazil-
dc.description.affiliationUSP, Fac Med, Unidade Endocrinol, BR-09500900 São Paulo, Brazil-
dc.description.affiliationUNESP, Fac Med, Unidade Endocrinol & Metab, São Paulo, Brazil-
dc.description.affiliationUnespUNESP, Fac Med, Unidade Endocrinol & Metab, São Paulo, Brazil-
dc.rights.accessRightsAcesso restrito-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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