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http://acervodigital.unesp.br/handle/11449/34605
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DC Field | Value | Language |
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dc.contributor.author | Castro, AVB | - |
dc.contributor.author | Mendonca, B. B. | - |
dc.contributor.author | Bloise, W. | - |
dc.contributor.author | Shuhama, T. | - |
dc.contributor.author | Brandao-Neto, J. | - |
dc.date.accessioned | 2014-05-20T15:23:55Z | - |
dc.date.accessioned | 2016-10-25T17:57:58Z | - |
dc.date.available | 2014-05-20T15:23:55Z | - |
dc.date.available | 2016-10-25T17:57:58Z | - |
dc.date.issued | 1999-12-01 | - |
dc.identifier | http://dx.doi.org/10.1023/A:1009225904221 | - |
dc.identifier.citation | Biometals. Dordrecht: Kluwer Academic Publ, v. 12, n. 4, p. 347-352, 1999. | - |
dc.identifier.issn | 0966-0844 | - |
dc.identifier.uri | http://hdl.handle.net/11449/34605 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/34605 | - |
dc.description.abstract | Previous in vitro studies have demonstrated zinc (Zn++) inhibition of basal and of potassium (K+) or thyrotropin-releasing hormone (TRH)-stimulated prolactin (PRL) secretion, in a selective, reversible, and dose-dependent manner. Thus, Zn++ may regulate physiologically pituitary PRL secretion. Furthermore, studies with patients with uremia, cirrhosis or prolactinoma, have shown the coexistence of hypozincemia and hyperprolactinemia and zinc supplementation did not correct hyperprolactinemia in these patients. In normal individuals Zn++ administration produced controversial results on PRL secretion. Here, we investigated whether zinc administration affects TRH-stimulated PRL in healthy men. We found that Zn++ administration does not change the TRH-stimulated PRL. Therefore, in normal conditions, Zn++ does not inhibit TRH-stimulated prolactinemia. In addition, we found that acute increases of blood PRL and TRH do not alter blood Zn++ levels. | en |
dc.format.extent | 347-352 | - |
dc.language.iso | eng | - |
dc.publisher | Kluwer Academic Publ | - |
dc.source | Web of Science | - |
dc.subject | zinc tolerance test | pt |
dc.subject | thyrotropin tolerance test | pt |
dc.subject | prolactin secretion | pt |
dc.subject | healthy men | pt |
dc.title | Effect of zinc administration on thyrotropin releasing hormone-stimulated prolactinemia in healthy men | en |
dc.type | outro | - |
dc.contributor.institution | Universidade de Brasília (UnB) | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | UnB, Fac Ciências Saude, Unidade Endocrinol & Metab, Brasilia, DF, Brazil | - |
dc.description.affiliation | USP, Fac Ciências Farmaceut, Lab Quim Analit, Ribeirao Preto, SP, Brazil | - |
dc.description.affiliation | USP, Fac Med, Unidade Endocrinol, BR-09500900 São Paulo, Brazil | - |
dc.description.affiliation | UNESP, Fac Med, Unidade Endocrinol & Metab, São Paulo, Brazil | - |
dc.description.affiliationUnesp | UNESP, Fac Med, Unidade Endocrinol & Metab, São Paulo, Brazil | - |
dc.identifier.doi | 10.1023/A:1009225904221 | - |
dc.identifier.wos | WOS:000085277700009 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Biometals | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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