Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/34633
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rodrigues, LNC | - |
dc.contributor.author | Zanoni, Maria Valnice Boldrin | - |
dc.contributor.author | Fogg, A. G. | - |
dc.date.accessioned | 2014-05-20T15:23:58Z | - |
dc.date.accessioned | 2016-10-25T17:58:00Z | - |
dc.date.available | 2014-05-20T15:23:58Z | - |
dc.date.available | 2016-10-25T17:58:00Z | - |
dc.date.issued | 1999-11-01 | - |
dc.identifier | http://dx.doi.org/10.1016/S0731-7085(99)00174-0 | - |
dc.identifier.citation | Journal of Pharmaceutical and Biomedical Analysis. Oxford: Pergamon-Elsevier B.V., v. 21, n. 3, p. 497-505, 1999. | - |
dc.identifier.issn | 0731-7085 | - |
dc.identifier.uri | http://hdl.handle.net/11449/34633 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/34633 | - |
dc.description.abstract | Cefaclor is not reducible at a mercury electrode, but it can be determined polarographically and by cathodic stripping voltammetry as its initial alkaline degradation product which is obtained in high yield by hydrolysis of cefaclor in Britton-Robinson (B-R) buffer pH 10 at 50 degrees C for 30 min (reduction peak at pH 10, -0.70 V). Differential pulse polarographic calibration graphs are linear up to at least 1 x 10(-4) mol l(-1). Recoveries of 93% of the cefaclor (n = 3) were obtained from urine spiked with 38.6 mu g ml(-1) using this polarographic method with 1 ml urine made up to 10 ml with pH 10 buffer. Using cathodic stripping voltammetry and accumulating at a hanging mercury drop electrode at -0.2 V for 30 s, linear calibration graphs were obtained from 0.35 to 40 mu g ml(-1) cefaclor in B-R buffer pH 10. A relative standard deviation of 4.2% (eta = 5) was obtained, and the limit of detection was calculated to be 2.9 ng ml(-1). Direct determination of cefaclor in human urine (1 ml of urine was made up to 10 ml with pH 10 buffer) spiked to 0.39 mu g ml(-1) was made (recovery 98.6%). (C) 1999 Elsevier B.V. B.V. All rights reserved. | en |
dc.format.extent | 497-505 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.subject | cefaclor determination | pt |
dc.subject | human urine analysis | pt |
dc.subject | stripping voltammetry | pt |
dc.subject | alkaline degradation | pt |
dc.subject | polarography | pt |
dc.title | Indirect polarographic and cathodic stripping voltammetric determination of cefaclor as an alkaline degradation product | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Loughborough Univ Technol | - |
dc.description.affiliation | UNESP, Inst Quim, Dept Quim Analit, BR-14800900 Araraquara, SP, Brazil | - |
dc.description.affiliation | Loughborough Univ Technol, Dept Chem, Loughborough LE11 3TU, Leics, England | - |
dc.description.affiliationUnesp | UNESP, Inst Quim, Dept Quim Analit, BR-14800900 Araraquara, SP, Brazil | - |
dc.identifier.doi | 10.1016/S0731-7085(99)00174-0 | - |
dc.identifier.wos | WOS:000084109300004 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Journal of Pharmaceutical and Biomedical Analysis | - |
dc.identifier.orcid | 0000-0002-2296-1393 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.