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dc.contributor.authorRodrigues, LNC-
dc.contributor.authorZanoni, Maria Valnice Boldrin-
dc.contributor.authorFogg, A. G.-
dc.identifier.citationJournal of Pharmaceutical and Biomedical Analysis. Oxford: Pergamon-Elsevier B.V., v. 21, n. 3, p. 497-505, 1999.-
dc.description.abstractCefaclor is not reducible at a mercury electrode, but it can be determined polarographically and by cathodic stripping voltammetry as its initial alkaline degradation product which is obtained in high yield by hydrolysis of cefaclor in Britton-Robinson (B-R) buffer pH 10 at 50 degrees C for 30 min (reduction peak at pH 10, -0.70 V). Differential pulse polarographic calibration graphs are linear up to at least 1 x 10(-4) mol l(-1). Recoveries of 93% of the cefaclor (n = 3) were obtained from urine spiked with 38.6 mu g ml(-1) using this polarographic method with 1 ml urine made up to 10 ml with pH 10 buffer. Using cathodic stripping voltammetry and accumulating at a hanging mercury drop electrode at -0.2 V for 30 s, linear calibration graphs were obtained from 0.35 to 40 mu g ml(-1) cefaclor in B-R buffer pH 10. A relative standard deviation of 4.2% (eta = 5) was obtained, and the limit of detection was calculated to be 2.9 ng ml(-1). Direct determination of cefaclor in human urine (1 ml of urine was made up to 10 ml with pH 10 buffer) spiked to 0.39 mu g ml(-1) was made (recovery 98.6%). (C) 1999 Elsevier B.V. B.V. All rights reserved.en
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectcefaclor determinationpt
dc.subjecthuman urine analysispt
dc.subjectstripping voltammetrypt
dc.subjectalkaline degradationpt
dc.titleIndirect polarographic and cathodic stripping voltammetric determination of cefaclor as an alkaline degradation producten
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionLoughborough Univ Technol-
dc.description.affiliationUNESP, Inst Quim, Dept Quim Analit, BR-14800900 Araraquara, SP, Brazil-
dc.description.affiliationLoughborough Univ Technol, Dept Chem, Loughborough LE11 3TU, Leics, England-
dc.description.affiliationUnespUNESP, Inst Quim, Dept Quim Analit, BR-14800900 Araraquara, SP, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Pharmaceutical and Biomedical Analysis-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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