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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/34987
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dc.contributor.authorCanduri, F.-
dc.contributor.authorUchoa, H. B.-
dc.contributor.authorde Azevedo, W. F.-
dc.date.accessioned2014-05-20T15:24:22Z-
dc.date.accessioned2016-10-25T17:58:33Z-
dc.date.available2014-05-20T15:24:22Z-
dc.date.available2016-10-25T17:58:33Z-
dc.date.issued2004-11-12-
dc.identifierhttp://dx.doi.org/10.1016/j.bbrc.2004.09.109-
dc.identifier.citationBiochemical and Biophysical Research Communications. San Diego: Academic Press Inc. Elsevier B.V., v. 324, n. 2, p. 661-666, 2004.-
dc.identifier.issn0006-291X-
dc.identifier.urihttp://hdl.handle.net/11449/34987-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/34987-
dc.description.abstractRoscovitine and flavopiridol have been shown to potently inhibit cyclin-dependent kinase 1 and 2 (CDK1 and 2). The structures of CDK2 complexed with roscovitine and deschoroflavopiridol have been reported, however no crystallographic structure is available for complexes of CDK1 with inhibitors. The present work describes two molecular models for the binary complexes CDK1:roscovitine and CDK1:flavopiridol. These structural models indicate that both inhibitors strongly bind to the ATP-binding pocket of CDKI and structural comparison of the CDK complexes correlates the structures with differences in inhibition of these CDKs by flavopiridol and roscovitine. This article explains the structural basis for the observed differences in activity of these inhibitors. (C) 2004 Elsevier B.V. All rights reserved.en
dc.format.extent661-666-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectCDKpt
dc.subjectdrug designpt
dc.subjectFlavopiridolpt
dc.subjectRoscovitinept
dc.subjecthomology modelingpt
dc.titleMolecular models of cyclin-dependent kinase 1 complexed with inhibitorsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionCtr Appl Toxicol-
dc.description.affiliationUNESP, Dept Fis, BR-15054000 Sao Jose do Rio Preto, SP, Brazil-
dc.description.affiliationUNESP, Programa Posgrad Biofis Mol, BR-15054000 Sao Jose do Rio Preto, SP, Brazil-
dc.description.affiliationCtr Appl Toxicol, Inst Butantan, BR-05503900 São Paulo, Brazil-
dc.description.affiliationUnespUNESP, Dept Fis, BR-15054000 Sao Jose do Rio Preto, SP, Brazil-
dc.description.affiliationUnespUNESP, Programa Posgrad Biofis Mol, BR-15054000 Sao Jose do Rio Preto, SP, Brazil-
dc.identifier.doi10.1016/j.bbrc.2004.09.109-
dc.identifier.wosWOS:000224794000028-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofBiochemical and Biophysical Research Communications-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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