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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/35394
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dc.contributor.authorGunatilaka, AAL-
dc.contributor.authorBolzani, Vanderlan da Silva-
dc.contributor.authorDagne, E.-
dc.contributor.authorHofmann, G. A.-
dc.contributor.authorJohnson, R. K.-
dc.contributor.authorMcCabe, F. L.-
dc.contributor.authorMattern, M. R.-
dc.contributor.authorKingston, DGI-
dc.date.accessioned2014-05-20T15:24:52Z-
dc.date.accessioned2016-10-25T17:59:11Z-
dc.date.available2014-05-20T15:24:52Z-
dc.date.available2016-10-25T17:59:11Z-
dc.date.issued1998-02-01-
dc.identifierhttp://dx.doi.org/10.1021/np9701687-
dc.identifier.citationJournal of Natural Products. Washington: Amer Chemical Soc, v. 61, n. 2, p. 179-184, 1998.-
dc.identifier.issn0163-3864-
dc.identifier.urihttp://hdl.handle.net/11449/35394-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/35394-
dc.description.abstractBioactivity-directed fractionation of the MeCOEt extract of Trichilia emetica (Meliaceae) resulted in the isolation of the limonoids nymania 1 (1), drageana 4 (3), trichilin A (4), rohituka 3 (5),and Tr-B (7) and the novel seco-A protolimonoid 8. of these, nymania 1 and Tr-B showed selective inhibitory activity toward DNA repair-deficient yeast mutants. The isolation, structure elucidation, C-13 NMR spectral assignments, and biological activities of:these compounds are reported.en
dc.format.extent179-184-
dc.language.isoeng-
dc.publisherAmer Chemical Soc-
dc.sourceWeb of Science-
dc.titleLimonoids showing selective toxicity to DNA repair-deficient yeast and other constituents of Trichilia emeticaen
dc.typeoutro-
dc.contributor.institutionVirginia Polytech Inst & State Univ-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionSmithKline Beecham Pharmaceut-
dc.contributor.institutionUniv Addis Ababa-
dc.description.affiliationVirginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA-
dc.description.affiliationUniv Estadual Paulista, Inst Quim, Araraquara, SP, Brazil-
dc.description.affiliationSmithKline Beecham Pharmaceut, Res & Dev, King of Prussia, PA 19406 USA-
dc.description.affiliationUniv Addis Ababa, Dept Chem, Addis Ababa, Ethiopia-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, Araraquara, SP, Brazil-
dc.identifier.doi10.1021/np9701687-
dc.identifier.wosWOS:000072377000002-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Natural Products-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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