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http://acervodigital.unesp.br/handle/11449/35833
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DC Field | Value | Language |
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dc.contributor.author | van Haeften, T. W. | - |
dc.contributor.author | Pimenta, W. | - |
dc.contributor.author | Mitrakou, A. | - |
dc.contributor.author | Korytkowski, M. | - |
dc.contributor.author | Jenssen, T. | - |
dc.contributor.author | Yki-Jarvinen, H. | - |
dc.contributor.author | Gerich, J. E. | - |
dc.date.accessioned | 2014-05-20T15:25:24Z | - |
dc.date.accessioned | 2016-10-25T17:59:52Z | - |
dc.date.available | 2014-05-20T15:25:24Z | - |
dc.date.available | 2016-10-25T17:59:52Z | - |
dc.date.issued | 2000-10-01 | - |
dc.identifier | http://dx.doi.org/10.1053/meta.2000.9526 | - |
dc.identifier.citation | Metabolism-clinical and Experimental. Philadelphia: W B Saunders Co, v. 49, n. 10, p. 1318-1325, 2000. | - |
dc.identifier.issn | 0026-0495 | - |
dc.identifier.uri | http://hdl.handle.net/11449/35833 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/35833 | - |
dc.description.abstract | We performed hyperglycemic clamps in 283 nondiabetic Caucasians and, with multiple linear regression, determined the contribution of beta-cell function and tissue insulin sensitivity to variations in glycemia and insulinemia during oral glucose tolerance tests (OGTTs). Impaired glucose tolerance (IGT) subjects had reduced insulin sensitivity(P < .02) and beta-cell function (P < .0001). Normal glucose tolerance (NGT) subjects with first-degree type 2 diabetic relatives had reduced first and second phase insulin secretion (both, P < .05), but normal insulin sensitivity(P = .37). beta-Cell function and insulin sensitivity accounted for one fourth of the variability in glucose tolerance. Fasting plasma glucose in subjects with NGT (n = 185) was a function of both phases of insulin secretion and of insulin sensitivity tall, P < .05), whereas, in IGT subjects (n = 98), it was a function of first phase insulin secretion and insulin sensitivity(P < .01). Two-hour glycemia was a function of second phase secretion and insulin sensitivity (P < .01). Fasting and 2-hour plasma insulin levels were determined by insulin sensitivity land glycemia) in NGT subjects (P < .001), but by second phase secretion in IGT (P < .001). We conclude that beta-cell function is reduced in subjects with IGT; glycemia and insulinemia are not regulated by the same mechanisms in IGT and NGT; insulin sensitivity does not contribute to insulinemia in IGT; family history of diabetes influences beta-cell function, but not insulin sensitivity in Caucasians. Copyright (C) 2000 by W.B. Saunders Company. | en |
dc.format.extent | 1318-1325 | - |
dc.language.iso | eng | - |
dc.publisher | W B Saunders Co | - |
dc.source | Web of Science | - |
dc.title | Relative contributions of beta-cell function and tissue insulin sensitivity to fasting and postglucose-load glycemia | en |
dc.type | outro | - |
dc.contributor.institution | Univ Utrecht | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Univ Athens | - |
dc.contributor.institution | Univ Pittsburgh | - |
dc.contributor.institution | Univ Oslo | - |
dc.contributor.institution | Univ Helsinki | - |
dc.contributor.institution | University of Rochester | - |
dc.description.affiliation | Univ Utrecht, Med Ctr, Dept Internal Med G 02 228, NL-3508 GA Utrecht, Netherlands | - |
dc.description.affiliation | Univ Estadual Paulista, Dept Internal Med, Botucatu, SP, Brazil | - |
dc.description.affiliation | Univ Athens, Dept Internal Med, Athens, Greece | - |
dc.description.affiliation | Univ Pittsburgh, Dept Endocrinol, Pittsburgh, PA USA | - |
dc.description.affiliation | Univ Oslo, Dept Internal Med, Oslo, Norway | - |
dc.description.affiliation | Univ Helsinki, Dept Endocrinol, Helsinki, Finland | - |
dc.description.affiliation | Univ Rochester, Dept Endocrinol, Rochester, NY USA | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Dept Internal Med, Botucatu, SP, Brazil | - |
dc.identifier.doi | 10.1053/meta.2000.9526 | - |
dc.identifier.wos | WOS:000089861800013 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Metabolism-clinical and Experimental | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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