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dc.contributor.authorvan Haeften, T. W.-
dc.contributor.authorPimenta, W.-
dc.contributor.authorMitrakou, A.-
dc.contributor.authorKorytkowski, M.-
dc.contributor.authorJenssen, T.-
dc.contributor.authorYki-Jarvinen, H.-
dc.contributor.authorGerich, J. E.-
dc.date.accessioned2014-05-20T15:25:24Z-
dc.date.accessioned2016-10-25T17:59:52Z-
dc.date.available2014-05-20T15:25:24Z-
dc.date.available2016-10-25T17:59:52Z-
dc.date.issued2000-10-01-
dc.identifierhttp://dx.doi.org/10.1053/meta.2000.9526-
dc.identifier.citationMetabolism-clinical and Experimental. Philadelphia: W B Saunders Co, v. 49, n. 10, p. 1318-1325, 2000.-
dc.identifier.issn0026-0495-
dc.identifier.urihttp://hdl.handle.net/11449/35833-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/35833-
dc.description.abstractWe performed hyperglycemic clamps in 283 nondiabetic Caucasians and, with multiple linear regression, determined the contribution of beta-cell function and tissue insulin sensitivity to variations in glycemia and insulinemia during oral glucose tolerance tests (OGTTs). Impaired glucose tolerance (IGT) subjects had reduced insulin sensitivity(P < .02) and beta-cell function (P < .0001). Normal glucose tolerance (NGT) subjects with first-degree type 2 diabetic relatives had reduced first and second phase insulin secretion (both, P < .05), but normal insulin sensitivity(P = .37). beta-Cell function and insulin sensitivity accounted for one fourth of the variability in glucose tolerance. Fasting plasma glucose in subjects with NGT (n = 185) was a function of both phases of insulin secretion and of insulin sensitivity tall, P < .05), whereas, in IGT subjects (n = 98), it was a function of first phase insulin secretion and insulin sensitivity(P < .01). Two-hour glycemia was a function of second phase secretion and insulin sensitivity (P < .01). Fasting and 2-hour plasma insulin levels were determined by insulin sensitivity land glycemia) in NGT subjects (P < .001), but by second phase secretion in IGT (P < .001). We conclude that beta-cell function is reduced in subjects with IGT; glycemia and insulinemia are not regulated by the same mechanisms in IGT and NGT; insulin sensitivity does not contribute to insulinemia in IGT; family history of diabetes influences beta-cell function, but not insulin sensitivity in Caucasians. Copyright (C) 2000 by W.B. Saunders Company.en
dc.format.extent1318-1325-
dc.language.isoeng-
dc.publisherW B Saunders Co-
dc.sourceWeb of Science-
dc.titleRelative contributions of beta-cell function and tissue insulin sensitivity to fasting and postglucose-load glycemiaen
dc.typeoutro-
dc.contributor.institutionUniv Utrecht-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Athens-
dc.contributor.institutionUniv Pittsburgh-
dc.contributor.institutionUniv Oslo-
dc.contributor.institutionUniv Helsinki-
dc.contributor.institutionUniversity of Rochester-
dc.description.affiliationUniv Utrecht, Med Ctr, Dept Internal Med G 02 228, NL-3508 GA Utrecht, Netherlands-
dc.description.affiliationUniv Estadual Paulista, Dept Internal Med, Botucatu, SP, Brazil-
dc.description.affiliationUniv Athens, Dept Internal Med, Athens, Greece-
dc.description.affiliationUniv Pittsburgh, Dept Endocrinol, Pittsburgh, PA USA-
dc.description.affiliationUniv Oslo, Dept Internal Med, Oslo, Norway-
dc.description.affiliationUniv Helsinki, Dept Endocrinol, Helsinki, Finland-
dc.description.affiliationUniv Rochester, Dept Endocrinol, Rochester, NY USA-
dc.description.affiliationUnespUniv Estadual Paulista, Dept Internal Med, Botucatu, SP, Brazil-
dc.identifier.doi10.1053/meta.2000.9526-
dc.identifier.wosWOS:000089861800013-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofMetabolism-clinical and Experimental-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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