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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/35893
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dc.contributor.authorMenezes, CMS-
dc.contributor.authorKirchgatter, K.-
dc.contributor.authorDi Santi, SMF-
dc.contributor.authorSavalli, C.-
dc.contributor.authorMonteiro, F. G.-
dc.contributor.authorPaula, G. A.-
dc.contributor.authorFerreira, E. I.-
dc.date.accessioned2014-05-20T15:25:28Z-
dc.date.accessioned2016-10-25T17:59:57Z-
dc.date.available2014-05-20T15:25:28Z-
dc.date.available2016-10-25T17:59:57Z-
dc.date.issued1997-11-01-
dc.identifierhttp://dx.doi.org/10.1016/S0035-9203(97)90529-0-
dc.identifier.citationTransactions of the Royal Society of Tropical Medicine and Hygiene. London: Royal Soc Tropical Medicine, v. 91, n. 6, p. 697-700, 1997.-
dc.identifier.issn0035-9203-
dc.identifier.urihttp://hdl.handle.net/11449/35893-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/35893-
dc.description.abstractBased on previous studies in vitro of the modulating effect of desipramine on chloroquine-resistance of Plasmodium falciparum, the effect of desipramine and imipramine on freshly isolated resistant Brazilian strains of the parasite was investigated. Both drugs in therapeutic doses showed an unexpected antimalarial effect in vitro in duplicate tests (IC50=44.26 and 46.53 mu g/L for desipramine, and 83.93 and 41.26 mu g/L for imipramine), but no reversal of resistance when added to cultures together with chloroquine.en
dc.format.extent697-700-
dc.language.isoeng-
dc.publisherRoyal Soc Tropical Medicine-
dc.sourceWeb of Science-
dc.subjectmalariapt
dc.subjectPlasmodium falciparumpt
dc.subjectchemotherapypt
dc.subjectdrug resistancept
dc.subjectchloroquinept
dc.subjectdesipraminept
dc.subjectimipraminept
dc.titleAntimalarial effect in vitro and lack of modulating effect of desipramine and imipramineen
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionSuperintendencia Controle Endemias-
dc.description.affiliationUniv São Paulo, Fac Ciências Farmaceut, BR-05389970 São Paulo, Brazil-
dc.description.affiliationUniv Estadual Paulista, Inst Ciências Saude, São Paulo, Brazil-
dc.description.affiliationSuperintendencia Controle Endemias, Div Programas Especiais, São Paulo, Brazil-
dc.description.affiliationUniv São Paulo, Inst Matemat & Estatist, São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Ciências Saude, São Paulo, Brazil-
dc.identifier.doi10.1016/S0035-9203(97)90529-0-
dc.identifier.wosWOS:000071357700021-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofTransactions of the Royal Society of Tropical Medicine and Hygiene-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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