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http://acervodigital.unesp.br/handle/11449/35893Registro de metadados completo
| Campo DC | Valor | Idioma |
|---|---|---|
| dc.contributor.author | Menezes, CMS | - |
| dc.contributor.author | Kirchgatter, K. | - |
| dc.contributor.author | Di Santi, SMF | - |
| dc.contributor.author | Savalli, C. | - |
| dc.contributor.author | Monteiro, F. G. | - |
| dc.contributor.author | Paula, G. A. | - |
| dc.contributor.author | Ferreira, E. I. | - |
| dc.date.accessioned | 2014-05-20T15:25:28Z | - |
| dc.date.accessioned | 2016-10-25T17:59:57Z | - |
| dc.date.available | 2014-05-20T15:25:28Z | - |
| dc.date.available | 2016-10-25T17:59:57Z | - |
| dc.date.issued | 1997-11-01 | - |
| dc.identifier | http://dx.doi.org/10.1016/S0035-9203(97)90529-0 | - |
| dc.identifier.citation | Transactions of the Royal Society of Tropical Medicine and Hygiene. London: Royal Soc Tropical Medicine, v. 91, n. 6, p. 697-700, 1997. | - |
| dc.identifier.issn | 0035-9203 | - |
| dc.identifier.uri | http://hdl.handle.net/11449/35893 | - |
| dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/35893 | - |
| dc.description.abstract | Based on previous studies in vitro of the modulating effect of desipramine on chloroquine-resistance of Plasmodium falciparum, the effect of desipramine and imipramine on freshly isolated resistant Brazilian strains of the parasite was investigated. Both drugs in therapeutic doses showed an unexpected antimalarial effect in vitro in duplicate tests (IC50=44.26 and 46.53 mu g/L for desipramine, and 83.93 and 41.26 mu g/L for imipramine), but no reversal of resistance when added to cultures together with chloroquine. | en |
| dc.format.extent | 697-700 | - |
| dc.language.iso | eng | - |
| dc.publisher | Royal Soc Tropical Medicine | - |
| dc.source | Web of Science | - |
| dc.subject | malaria | pt |
| dc.subject | Plasmodium falciparum | pt |
| dc.subject | chemotherapy | pt |
| dc.subject | drug resistance | pt |
| dc.subject | chloroquine | pt |
| dc.subject | desipramine | pt |
| dc.subject | imipramine | pt |
| dc.title | Antimalarial effect in vitro and lack of modulating effect of desipramine and imipramine | en |
| dc.type | outro | - |
| dc.contributor.institution | Universidade de São Paulo (USP) | - |
| dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
| dc.contributor.institution | Superintendencia Controle Endemias | - |
| dc.description.affiliation | Univ São Paulo, Fac Ciências Farmaceut, BR-05389970 São Paulo, Brazil | - |
| dc.description.affiliation | Univ Estadual Paulista, Inst Ciências Saude, São Paulo, Brazil | - |
| dc.description.affiliation | Superintendencia Controle Endemias, Div Programas Especiais, São Paulo, Brazil | - |
| dc.description.affiliation | Univ São Paulo, Inst Matemat & Estatist, São Paulo, Brazil | - |
| dc.description.affiliationUnesp | Univ Estadual Paulista, Inst Ciências Saude, São Paulo, Brazil | - |
| dc.identifier.doi | 10.1016/S0035-9203(97)90529-0 | - |
| dc.identifier.wos | WOS:000071357700021 | - |
| dc.rights.accessRights | Acesso restrito | - |
| dc.relation.ispartof | Transactions of the Royal Society of Tropical Medicine and Hygiene | - |
| Aparece nas coleções: | Artigos, TCCs, Teses e Dissertações da Unesp | |
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