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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/35919
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dc.contributor.authorCastro, AVB-
dc.contributor.authorMendonca, B. B.-
dc.contributor.authorBloise, W.-
dc.contributor.authorShuhama, T.-
dc.contributor.authorBrandao-Neto, J.-
dc.date.accessioned2014-05-20T15:25:30Z-
dc.date.accessioned2016-10-25T18:00:00Z-
dc.date.available2014-05-20T15:25:30Z-
dc.date.available2016-10-25T18:00:00Z-
dc.date.issued2002-01-01-
dc.identifierhttp://dx.doi.org/10.1016/S0946-672X(02)80031-1-
dc.identifier.citationJournal of Trace Elements In Medicine and Biology. Jena: Urban & Fischer Verlag, v. 16, n. 2, p. 69-73, 2002.-
dc.identifier.issn0946-672X-
dc.identifier.urihttp://hdl.handle.net/11449/35919-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/35919-
dc.description.abstractDopamine (DA) and zinc (Zn++) share common mechanisms in their inhibition of prolactin (PRL) secretion. Both substances are present in the same brain areas, where Zn++ is released together with DA, suggesting a modulatory effect of Zn++ on dopaminergic receptors. The aim of the present study was to evaluate the effect of Zn supplementation on basal and PRL secretion stimulated by metoclopramide (MCP), a dopaminergic antagonist. Seven healthy men were evaluated in controlled study, where MCP (5 mg) was given intravenously, before and after 3 months of oral Zn++ (25 mg) administration. Our results indicate that chronic Zn++ administration does not change basal or MCP-stimulated plasma PRL secretion suggesting that, in humans, Zn++ does not interfere on PRL secretion mediated through dopaminergic receptors.en
dc.format.extent69-73-
dc.language.isoeng-
dc.publisherUrban & Fischer Verlag-
dc.sourceWeb of Science-
dc.subjectzinc supplementationpt
dc.subjectprolactin secretionpt
dc.subjectmetoclopramidept
dc.subjecthealthy menpt
dc.titleZinc supplementation does not inhibit basal and metoclopramide-stimulated prolactinemia secretion in healthy menen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte (UFRN)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Fed Rio Grande Norte, Ctr Ciências Saude, Unidade Endocrinol & Metab, BR-59072970 Natal, RN, Brazil-
dc.description.affiliationUniv São Paulo, Fac Med, Unidade Endocrinol, BR-05508900 São Paulo, Brazil-
dc.description.affiliationUniv São Paulo, Fac Ciências Farmaceut, Lab Quim Analit, BR-14049 Ribeirao Preto, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Med, Unidade Endocrinol & Metab, Botucatu, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Fac Med, Unidade Endocrinol & Metab, Botucatu, SP, Brazil-
dc.identifier.doi10.1016/S0946-672X(02)80031-1-
dc.identifier.wosWOS:000177406700001-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Trace Elements In Medicine and Biology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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