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DC Field | Value | Language |
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dc.contributor.author | Menani, José Vanderlei | - |
dc.contributor.author | Johnson, A. K. | - |
dc.date.accessioned | 2014-05-20T15:25:48Z | - |
dc.date.accessioned | 2016-10-25T18:00:22Z | - |
dc.date.available | 2014-05-20T15:25:48Z | - |
dc.date.available | 2016-10-25T18:00:22Z | - |
dc.date.issued | 1998-11-01 | - |
dc.identifier | http://ajpregu.physiology.org/content/275/5/R1431 | - |
dc.identifier.citation | American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 275, n. 5, p. R1431-R1437, 1998. | - |
dc.identifier.issn | 0363-6119 | - |
dc.identifier.uri | http://hdl.handle.net/11449/36144 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/36144 | - |
dc.description.abstract | The present study investigated the effects of bilateral injections of the nonselective CCK receptor antagonist proglumide or CCK-8 into the lateral parabrachial nuclei (LPBN) on the ingestion of 0.3 M NaCl and water induced by intracerebroventricular injection of ANG II or by a combined treatment with subcutaneous furosemide (Furo) + captopril (Cap). Compared with the injection of saline (vehicle), bilateral LPBN injections of proglumide (50 mu g . 200 nl(-1). site(-1)) increased the intake of 0.3 ill NaCl induced by intracerebroventricular ANG II (50 ng/1 mu l). Bilateral injections of proglumide into the LPBN also increased ANG II-induced water intake when NaCl was simultaneously available, but not when only water was present. Similarly, the ingestion of 0.3 M NaCl and water induced by the treatment with Furo (10 mg/kg) + Cap (5 mg/kg) was increased by bilateral LPBN proglumide pretreatment. Bilateral CCK-8 (0.5 mu g . 200 nl(-1). site(-1)) injections into the LPBN did not change Furo + Cap-induced 0.3 M NaCl intake but reduced water consumption. When only water was available after intracerebroventricular ANG II, bilateral LPBN injections of proglumide or CCK-8 had no effect or significantly reduced water intake compared with LPBN vehicle-treated rats. Taken together, these results suggest that CCK actions in the LPBN play a modulatory role on the control of NaCl and water intake induced by experimental treatments that induce hypovolemia and/or hypotension or that mimic those states. | en |
dc.format.extent | R1431-R1437 | - |
dc.language.iso | eng | - |
dc.publisher | Amer Physiological Soc | - |
dc.source | Web of Science | - |
dc.subject | sodium chloride intake | pt |
dc.subject | water intake | pt |
dc.subject | proglumide | pt |
dc.subject | sodium appetite | pt |
dc.title | Cholecystokinin actions in the parabrachial nucleus: effects on thirst and salt appetite | en |
dc.type | outro | - |
dc.contributor.institution | Univ Iowa | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Univ Iowa, Dept Psychol, Iowa City, IA 52242 USA | - |
dc.description.affiliation | Univ Iowa, Dept Pharmacol, Iowa City, IA 52242 USA | - |
dc.description.affiliation | Univ Iowa, Ctr Cardiovasc, Iowa City, IA 52242 USA | - |
dc.description.affiliation | Paulista State Univ, Fac Odontol, Dept Ciências Fisiol, BR-14801903 São Paulo, Brazil | - |
dc.description.affiliationUnesp | Paulista State Univ, Fac Odontol, Dept Ciências Fisiol, BR-14801903 São Paulo, Brazil | - |
dc.identifier.wos | WOS:000076880700007 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.relation.ispartof | American Journal of Physiology: Regulatory Integrative and Comparative Physiology | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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