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DC Field | Value | Language |
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dc.contributor.author | Novelli, ELB | - |
dc.contributor.author | Rodrigues, N. L. | - |
dc.contributor.author | Ribas, B. O. | - |
dc.date.accessioned | 2014-05-20T15:26:29Z | - |
dc.date.accessioned | 2016-10-25T18:01:07Z | - |
dc.date.available | 2014-05-20T15:26:29Z | - |
dc.date.available | 2016-10-25T18:01:07Z | - |
dc.date.issued | 1995-03-01 | - |
dc.identifier | http://dx.doi.org/10.1177/096032719501400303 | - |
dc.identifier.citation | Human & Experimental Toxicology. Basingstoke: Stockton Press, v. 14, n. 3, p. 248-251, 1995. | - |
dc.identifier.issn | 0144-5952 | - |
dc.identifier.uri | http://hdl.handle.net/11449/36647 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/36647 | - |
dc.description.abstract | Three nickel compounds were tested for pancreatic, hepatic and osteogenic damage in rats by a single i.m. injection Ni++ (7 mg kg(-1)). The nickel induced biochemical alterations included significantly increased levels of serum alkaline phosphatase in rats with NiS (75%) and NiO (50%). Amylase and aspartate transaminase were also increased, and lipoperoxide was increased in rats with NiO (5.6-fold) and NiS (3.4-fold). No serum changes were observed with NiCl2. Daily injection of Cu-Zn superoxide dismutase (SOD) conjugated with polyethylene glycol prevented the serum level changes, indicating that superoxide radical is an important intermediate in toxicity of nickel insoluble compounds. | en |
dc.format.extent | 248-251 | - |
dc.language.iso | eng | - |
dc.publisher | Stockton Press | - |
dc.source | Web of Science | - |
dc.subject | NICKEL | pt |
dc.subject | SUPEROXIDE RADICAL | pt |
dc.subject | TOXICITY | pt |
dc.subject | SUPEROXIDE DISMUTASE | pt |
dc.subject | RATS | pt |
dc.title | SUPEROXIDE RADICAL AND TOXICITY OF ENVIRONMENTAL NICKEL EXPOSURE | en |
dc.type | outro | - |
dc.contributor.institution | INST SALUD CARLOS 3 | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | INST SALUD CARLOS 3,MINIST SANIDAD & CONSUMO,MADRID,SPAIN | - |
dc.identifier.doi | 10.1177/096032719501400303 | - |
dc.identifier.wos | WOS:A1995QQ39500004 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Human & Experimental Toxicology | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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