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dc.contributor.authorCicogna, Antonio Carlos-
dc.contributor.authorMatsubara, Beatriz Bojikian-
dc.contributor.authorMatsubara, Luiz Shiguero-
dc.contributor.authorOkoshi, Katashi-
dc.contributor.authorGut, Ana Lúcia-
dc.contributor.authorPadovani, Carlos Roberto-
dc.contributor.authorMeyer, M. M.-
dc.contributor.authorOkoshi, Marina Politi-
dc.identifier.citationJapanese Heart Journal. Tokyo: Japan Heart Journal, Second Dept of Internal Med, v. 43, n. 6, p. 689-695, 2002.-
dc.description.abstractThe aim of this study was to demonstrate that hypertrophied cardiac muscle is more sensitive to volume-overload than normal cardiac muscle. We assessed the mechanical function of isolated left ventricular papillary muscle from male spontaneously hypertensive rats (SHR) and age-matched normotensive Wistar-Kyoto rats (WKY) Submitted to volume overload caused by aortocaval fistula (ACF) for 30 days. Muscles were perfused with Krebs-Henseleit solution at 28degreesC and Studied isometrically at a Stimulation rate of 0.2 Hz. The ACF increased the right and left ventricular weight-to-body weight ratio in WKY rats; it also promoted right ventricular hypertrophy and further increased the basal hypertrophy in the left ventricle from SHR. The arterial systolic pressure was greater in SHR than in WKY rats, and decreased with ACF in both groups. Developed tension (DT) and maximum rate of DT (+dT/dt) were greater in the SHR-control than in the WKY-control (P<0.05); the time from peak tension to 50% relaxation (RT1/2) was similar in these animals. ACE did not change any parameters ill the SHR group and increased the resting tension in the WKY group. However, the significant difference observed between myocardial contraction performance in WKY-controls and SHR-controls disappeared when the SHR-ACF and WKY-controls were compared. Furthermore, RT1/2 increased significantly ill the SHR-ACF in relation to the WKY-controls. In conclusion, the data lead LIS to infer that volume-overload for 30 days promotes more mechanical functional changes in hypertrophied muscle than in normal cardiac muscle.en
dc.publisherJapan Heart Journal, Second Dept of Internal Med-
dc.sourceWeb of Science-
dc.subjectspontaneously hypertensive ratspt
dc.subjectvolume overloadpt
dc.subjectmyocardium functionpt
dc.subjectisolated musclept
dc.titleVolume overload influence on hypertrophied myocardium functionen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationState Univ Julio de Mesquita Filho, Sch Med Botucatu, Dept Internal Med, Botucatu, SP, Brazil-
dc.description.affiliationUnespState Univ Julio de Mesquita Filho, Sch Med Botucatu, Dept Internal Med, Botucatu, SP, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJapanese Heart Journal-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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