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dc.contributor.authorSilva, Márcio Pereirada-
dc.contributor.authorTorsoni, Márcio A.-
dc.contributor.authorNourani, Hugo V.-
dc.contributor.authorAugusto, Viviane D.-
dc.contributor.authorSouza, Cláudio T.-
dc.contributor.authorGasparetti, Alessandra L.-
dc.contributor.authorCarvalheira, José B.-
dc.contributor.authorVentrucci, Gislaine-
dc.contributor.authorMarcondes, Maria Cristina C. G.-
dc.contributor.authorCruz Neto, Ariovaldo P.-
dc.contributor.authorSaad, Mário J. A.-
dc.contributor.authorBoschero, Antonio C.-
dc.contributor.authorCarneiro, Everardo M.-
dc.contributor.authorVelloso, Lício A.-
dc.identifier.citationEndocrinology. Bethesda: Endocrine Soc, v. 144, n. 11, p. 4831-4840, 2003.-
dc.description.abstractShort-term cold exposure of homeothermic animals leads to higher thermogenesis and food consumption accompanied by weight loss. An analysis of cDNA-macroarray was employed to identify candidate mRNA species that encode proteins involved in thermogenic adaptation to cold. A cDNA-macroarray analysis, confirmed by RT-PCR, immunoblot, and RIA, revealed that the hypothalamic expression of melanin-concentrating hormone (MCH) is enhanced by exposure of rats to cold environment. The blockade of hypothalamic MCH expression by antisense MCH oligonucleotide in cold-exposed rats promoted no changes in feeding behavior and body temperature. However, MCH blockade led to a significant drop in body weight, which was accompanied by decreased liver glycogen, increased relative body fat, increased absolute and relative interscapular brown adipose tissue mass, increased uncoupling protein 1 expression in brown adipose tissue, and increased consumption of lean body mass. Thus, increased hypothalamic MCH expression in rats exposed to cold may participate in the process that allows for efficient use of energy for heat production during thermogenic adaptation to cold.en
dc.publisherEndocrine Soc-
dc.sourceWeb of Science-
dc.titleHypothalamic melanin-concentrating hormone is induced by cold exposure and participates in the control of energy expenditure in ratsen
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationUniv Estadual Campinas, Dept Internal Med, BR-13083970 Campinas, SP, Brazil-
dc.description.affiliationUniv Estadual Campinas, Dept Physiol & Biophys, BR-13083970 Campinas, SP, Brazil-
dc.description.affiliationState Univ São Paulo, Paulista State Univ, Dept Zool, BR-13083970 Campinas, SP, Brazil-
dc.description.affiliationUnespUNESP, Rio Claro, Department of Zoology-
dc.rights.accessRightsAcesso restrito-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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