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dc.contributor.authorSuleiman, M.-
dc.contributor.authorCury, P. M.-
dc.contributor.authorPestana, JOM-
dc.contributor.authorBurdmann, E. A.-
dc.contributor.authorBueno, V-
dc.identifier.citationTransplantation Proceedings. New York: Elsevier B.V., v. 37, n. 1, p. 373-374, 2005.-
dc.description.abstractIschemia/reperfusion (I/R) injury, a common early feature in renal transplantation, results from both free radical species generation and local inflammatory responses that attract different types of cells. The interaction with infiltrating leukocytes could promote damage and death of resident renal cells contributing to worsening of renal function. It has been shown that depletion of host T cells protects against kidney damage after I/R injury, although the mechanism is not fully understood. FTY720, a synthetic analog of a natural product extracted from Isaria sincclairii has shown modulatory properties in experimental models of autoimmune disease, transplantation, and I/R injury. FTY720 alters lymphocyte responses to chemokine homing signals, thereby decreasing the number of lymphocytes in inflammatory sites. We evaluated renal function in mice at 3, 5, and 7 days after I/R injury in the presence or absence of FTY720 treatment. FTY720 treatment promoted earlier recovery of renal function associated with a lower number of renal-infiltrating lymphocytes. These findings confirm previous results showing a protective effect of FTY720 in I/R injury models.en
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.titleFTY720 prevents renal T-Cell infiltration after ischemia/reperfusion injuryen
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)-
dc.description.affiliationFAMERP, Sao Jose Rio Preto Med Sch, Dept Pathol, BR-15091280 São Paulo, Brazil-
dc.description.affiliationFAMERP, Div Nephrol, BR-15091280 São Paulo, Brazil-
dc.description.affiliationFAMERP, Immunol Lab, BR-15091280 São Paulo, Brazil-
dc.description.affiliationUniv Estadual Paulista, São Paulo, Brazil-
dc.description.affiliationUniv Fed São Paulo, Renal Transplantat Grp, São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, São Paulo, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofTransplantation Proceedings-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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