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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/37281
Título: 
Macrophages and mast cells control the neutrophil migration induced by dentin proteins
Autor(es): 
Instituição: 
  • Universidade de São Paulo (USP)
  • Universidade Estadual Paulista (UNESP)
  • Univ Texas
ISSN: 
0022-0345
Resumo: 
Dentin sialoprotein (DSP) and dentin phosphoprotein (DPP), the major dentin proteins, have been shown to induce neutrophil migration through release of IL-1beta, TNF-alpha, MIP-2, and KC. However, the sources of these mediators were not determined. Here, the roles of macrophages and mast cells (MC) in dentin-induced neutrophil accumulation were investigated. Peritoneal MC depletion or the enhancement of macrophage population increased DSP- and DPP-induced neutrophil extravasation. Moreover, supernatants from DSP- and DPP-stimulated macrophages caused neutrophil migration. The release of neutrophil chemotactic factor by macrophages was inhibited by dexamethasone or the supernatant of DSP- treated MC. Consistently, dexamethasone and the MC supernatant inhibited the production of IL-1beta, TNF-alpha, and MIP-2 by macrophages. This inhibitory activity of the DSP- stimulated MC was neutralized by anti-IL-4 and anti-IL-10 antibodies. These results indicate that dentin induces the release of the neutrophil chemotactic substance(s) by macrophages, which are down-modulated by MC-derived IL-4 and IL-10.
Data de publicação: 
1-Jan-2005
Citação: 
Journal of Dental Research. Alexandria: Int Amer Associação Dental Researchi A D R/a A D R, v. 84, n. 1, p. 79-83, 2005.
Duração: 
79-83
Publicador: 
Int Amer Assoc Dental Researchi
Palavras-chaves: 
  • neutrophil chemotaxis
  • DSP
  • DPP
Fonte: 
http://dx.doi.org/10.1177/154405910508400114
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/37281
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