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dc.contributor.authorSilva, T. A.-
dc.contributor.authorLara, V. S.-
dc.contributor.authorSilva, J. S.-
dc.contributor.authorOliveira, SHP-
dc.contributor.authorButler, W. T.-
dc.contributor.authorCunha, F. Q.-
dc.identifier.citationJournal of Dental Research. Alexandria: Int Amer Associação Dental Researchi A D R/a A D R, v. 84, n. 1, p. 79-83, 2005.-
dc.description.abstractDentin sialoprotein (DSP) and dentin phosphoprotein (DPP), the major dentin proteins, have been shown to induce neutrophil migration through release of IL-1beta, TNF-alpha, MIP-2, and KC. However, the sources of these mediators were not determined. Here, the roles of macrophages and mast cells (MC) in dentin-induced neutrophil accumulation were investigated. Peritoneal MC depletion or the enhancement of macrophage population increased DSP- and DPP-induced neutrophil extravasation. Moreover, supernatants from DSP- and DPP-stimulated macrophages caused neutrophil migration. The release of neutrophil chemotactic factor by macrophages was inhibited by dexamethasone or the supernatant of DSP- treated MC. Consistently, dexamethasone and the MC supernatant inhibited the production of IL-1beta, TNF-alpha, and MIP-2 by macrophages. This inhibitory activity of the DSP- stimulated MC was neutralized by anti-IL-4 and anti-IL-10 antibodies. These results indicate that dentin induces the release of the neutrophil chemotactic substance(s) by macrophages, which are down-modulated by MC-derived IL-4 and IL-10.en
dc.publisherInt Amer Assoc Dental Researchi-
dc.sourceWeb of Science-
dc.subjectneutrophil chemotaxispt
dc.titleMacrophages and mast cells control the neutrophil migration induced by dentin proteinsen
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Texas-
dc.description.affiliationUniv São Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, BR-05508 São Paulo, Brazil-
dc.description.affiliationUniv São Paulo, Sch Med Ribeirao Preto, Dept Biochem & Immunol, BR-05508 São Paulo, Brazil-
dc.description.affiliationAracatuba State Univ São Paulo, Sch Dent, Dept Basic Sci, Aracatuba, SP, Brazil-
dc.description.affiliationUniv Texas, Houston Hlth Sci Ctr, Dept Basic Sci, Dent Branch, Houston, TX 77025 USA-
dc.description.affiliationUnespAracatuba State Univ São Paulo, Sch Dent, Dept Basic Sci, Aracatuba, SP, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Dental Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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