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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/37406
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dc.contributor.authorTrovatti, Eliane-
dc.contributor.authorBadino, Alberto Colli-
dc.contributor.authorHokka, Carlos Osamu-
dc.contributor.authorGonsales da Costa Araujo, Maria Lucia-
dc.date.accessioned2014-05-20T15:27:25Z-
dc.date.accessioned2016-10-25T18:02:14Z-
dc.date.available2014-05-20T15:27:25Z-
dc.date.available2016-10-25T18:02:14Z-
dc.date.issued2006-02-01-
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_issues&pid=1516-8913&lng=en&nrm=iso-
dc.identifier.citationBrazilian Archives of Biology and Technology. Curitiba-Paraná: Inst Tecnologia Parana, v. 49, p. 173-179, 2006.-
dc.identifier.issn1516-8913-
dc.identifier.urihttp://hdl.handle.net/11449/37406-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/37406-
dc.description.abstractThe effect of nitrogen source on clavulanic acid production was investigated in shake flasks. Media containing asparagine plus one of several different amino acids or a combination of two amino acids was tested. The best result, ca. 180 mg/L clavulanic acid, CA, in 60 h, was obtained with the lysine-tyrosine pair In an aerated and agitated fermentor this medium led to CA concentrations of ca. 210 mg/L, a remarkable production for synthetic medium utilization. Amino acids analysis during cultivation indicated that, while asparagine was consumed rapidly, lysine and tyrosine were metabolized slowly, promoting CA production.en
dc.format.extent173-179-
dc.language.isoeng-
dc.publisherInst Tecnologia Parana-
dc.sourceWeb of Science-
dc.subjectclavulanic acidpt
dc.subjectb-lactamase inhibitorpt
dc.subjectS. clavuligeruspt
dc.subjectsynthetic mediumpt
dc.subjectamino acidspt
dc.titleInfluence of free amino acids on clavulanic acid production by Streptomyces clavuligerus in synthetic mediumen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)-
dc.description.affiliationUNESP, Dept Bioquim & Tecnol Quim, Inst Quim, BR-14801970 Araraquara, SP, Brazil-
dc.description.affiliationUFSCar, Dept Engn Quim, BR-13565905 Sao Carlos, SP, Brazil-
dc.description.affiliationUnespUNESP, Dept Bioquim & Tecnol Quim, Inst Quim, BR-14801970 Araraquara, SP, Brazil-
dc.identifier.wosWOS:000239655700024-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofBrazilian Archives of Biology and Technology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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